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Differences in macular capillary parameters between healthy black and white subjects with Optical Coherence Tomography Angiography (OCTA)


Autoři: Lindsay Y. Chun aff001;  Megan R. Silas aff002;  Rose C. Dimitroyannis aff002;  Kimberly Ho aff002;  Dimitra Skondra aff002
Působiště autorů: University of Chicago Pritzker School of Medicine, Chicago, IL, United States of America aff001;  Department of Ophthalmology and Visual Science, University of Chicago Medical Center, Chicago, IL, United States of America aff002;  University of Chicago, Chicago, IL, United States of America aff003;  J. Terry Ernest Ocular Imaging Center, University of Chicago Medical Center, Chicago, IL, United States of America aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0223142

Souhrn

Purpose

To investigate if there are differences in macular capillaries between black and white subjects using optical coherence tomography angiography (OCTA) and identify potential factors underlying the epidemiologically-based higher vulnerability of black populations to diabetic retinopathy (DR).

Methods

This prospective, observational cross-sectional study included 93 eyes of 47 healthy subjects with no medical history and ocular history who self-identified as black or white and were matched for age, sex, refractive error, and image quality. Subjects underwent OCTA imaging (RTVue-XR Avanti) of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris. AngioAnalytics was used to analyze vessel density (VD) and choriocapillaris % blood flow area (BFA) in the 1mm-diameter fovea, parafovea, and 3mm-diameter circular area including the fovea and parafovea (3x3mm image). Foveal avascular zone (FAZ) was also analyzed. Linear mixed models were used to evaluate for differences between the study groups.

Results

Compared to the white subjects in this study, black subjects were found to have: lower foveal VD in the SCP (p<0.05); lower VD in the parafovea and in the 3x3mm image in the DCP (p<0.05); larger FAZ in SCP and DCP (p<0.05); and decreased choriocapillary BFA in the area underlying the fovea, parafovea, and 3x3mm image (p<0.05).

Conclusion

In our study, our black subjects had decreased macular capillary vasculature compared to matched white subjects, even in early adulthood and the absence of any systemic or ocular conditions. To our knowledge, this is the first report showing that retinal and choriocapillary vascular differences may contribute to racial disparities in vulnerability to DR.

Klíčová slova:

Eyes – Ethnic epidemiology – Blood flow – Retinal vessels – Retina – Fovea centralis – Capillaries


Zdroje

1. Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2017 [Internet]. 2017. Available from: https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf

2. US Department of Health and Human Services Office of Minority Health. Diabetes and African Americans [Internet]. 2016. Available from: https://minorityhealth.hhs.gov/omh/browse.aspx?lvl=4&lvlid=18

3. Sivaprasad S, Gupta B, Gulliford MC, Dodhia H, Mohamed M, Nagi D, et al. Ethnic Variations in the Prevalence of Diabetic Retinopathy in People with Diabetes Attending Screening in the United Kingdom (DRIVE UK). Barengo NC, editor. PLoS ONE. 2012 Mar 8;7(3):e32182. doi: 10.1371/journal.pone.0032182 22412857

4. Emanuele N, Sacks J, Klein R, Reda D, Anderson R, Duckworth W, et al. Ethnicity, race, and baseline retinopathy correlates in the veterans affairs diabetes trial. Diabetes Care. 2005;28(8):1954–1958. doi: 10.2337/diacare.28.8.1954 16043738

5. Harris EL, Sherman SH, Georgopoulos A. Black-white differences in risk of developing retinopathy among individuals with type 2 diabetes. Diabetes Care. 1999;22(5):779–783. doi: 10.2337/diacare.22.5.779 10332681

6. Mathur R, Bhaskaran K, Edwards E, Lee H, Chaturvedi N, Smeeth L, et al. Population trends in the 10-year incidence and prevalence of diabetic retinopathy in the UK: a cohort study in the Clinical Practice Research Datalink 2004–2014. BMJ Open. 2017;7(2):e014444. doi: 10.1136/bmjopen-2016-014444 28246144

7. Wong TY, Klein R, Islam FMA, Cotch MF, Folsom AR, Klein BEK, et al. Diabetic Retinopathy in a Multi-ethnic Cohort in the United States. Am J Ophthalmol. 2006 Mar;141(3):446–455.e1. doi: 10.1016/j.ajo.2005.08.063 16490489

8. Leske MC, Wu S-Y, Nemesure B, Hennis A. Causes of visual loss and their risk factors: an incidence summary from the Barbados Eye Studies. Rev Panam Salud Pública. 2010;27(4):259–267. doi: 10.1590/s1020-49892010000400004 20512228

9. Leske M, Wu S, Hennis A, Hyman L, Nemesure B, Yang L, et al. Hyperglycemia, Blood Pressure, and the 9-Year Incidence of Diabetic RetinopathyThe Barbados Eye Studies. Ophthalmology. 2005 May;112(5):799–805. doi: 10.1016/j.ophtha.2004.11.054 15878059

10. Leasher JL, Bourne RRA, Flaxman SR, Jonas JB, Keeffe J, Naidoo K, et al. Global Estimates on the Number of People Blind or Visually Impaired by Diabetic Retinopathy: A Meta-analysis From 1990 to 2010. Diabetes Care. 2016 Sep;39(9):1643–9. doi: 10.2337/dc15-2171 27555623

11. Kempen JH, O’Colmain BJ, Leske MC, Haffner SM, Klein R, Moss SE, et al. The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol Chic Ill 1960. 2004 Apr;122(4):552–63.

12. Harris MI, Klein R, Cowie CC, Rowland M, Byrd-Holt DD. Is the risk of diabetic retinopathy greater in non-Hispanic blacks and Mexican Americans than in non-Hispanic whites with type 2 diabetes?: A US population study. Diabetes Care. 1998;21(8):1230–1235. doi: 10.2337/diacare.21.8.1230 9702425

13. Klein R, Sharrett AR, Klein BE, Moss SE, Folsom AR, Wong TY, et al. The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes: the atherosclerosis risk in communities study. Ophthalmology. 2002;109(7):1225–1234. doi: 10.1016/s0161-6420(02)01074-6 12093643

14. Klein R, Marino EK, Kuller LH, Polak JF, Tracy RP, Gottdiener JS, et al. The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health Study. Br J Ophthalmol. 2002;86(1):84–90. doi: 10.1136/bjo.86.1.84 11801510

15. Zhang X, Saaddine JB, Chou C-F, Cotch MF, Cheng YJ, Geiss LS, et al. Prevalence of diabetic retinopathy in the United States, 2005–2008. Jama. 2010;304(6):649–656. doi: 10.1001/jama.2010.1111 20699456

16. Lanting LC, Joung IM, Mackenbach JP, Lamberts SW, Bootsma AH. Ethnic differences in mortality, end-stage complications, and quality of care among diabetic patients: a review. Diabetes Care. 2005;28(9):2280–2288. doi: 10.2337/diacare.28.9.2280 16123507

17. Schwartz S, Hampton B, Brantley M, Flynn H. Update on genetics and diabetic retinopathy. Clin Ophthalmol. 2015 Nov;2175. doi: 10.2147/OPTH.S94508 26648684

18. Spanakis EK, Golden SH. Race/Ethnic Difference in Diabetes and Diabetic Complications. Curr Diab Rep. 2013 Dec;13(6):814–23. doi: 10.1007/s11892-013-0421-9 24037313

19. National Eye Institute. Diabetic Retinopathy [Internet]. 2010. Available from: https://nei.nih.gov/eyedata/diabetic

20. Wagner-Schuman M, Dubis AM, Nordgren RN, Lei Y, Odell D, Chiao H, et al. Race- and Sex-Related Differences in Retinal Thickness and Foveal Pit Morphology. Investig Opthalmology Vis Sci. 2011 Jan 31;52(1):625.

21. Kashani AH, Zimmer-Galler IE, Shah SM, Dustin L, Do DV, Eliott D, et al. Retinal Thickness Analysis by Race, Gender, and Age Using Stratus OCT. Am J Ophthalmol. 2010 Mar;149(3):496–502.e1. doi: 10.1016/j.ajo.2009.09.025 20042179

22. Yu S, Pang CE, Gong Y, Freund KB, Yannuzzi LA, Rahimy E, et al. The Spectrum of Superficial and Deep Capillary Ischemia in Retinal Artery Occlusion. Am J Ophthalmol. 2015 Jan;159(1):53–63.e2. doi: 10.1016/j.ajo.2014.09.027 25244976

23. Rao HL, Pradhan ZS, Weinreb RN, Reddy HB, Riyazuddin M, Sachdeva S, et al. Determinants of Peripapillary and Macular Vessel Densities Measured by Optical Coherence Tomography Angiography in Normal Eyes: J Glaucoma. 2017 May;26(5):491–7. doi: 10.1097/IJG.0000000000000655 28263261

24. Yu J, Jiang C, Wang X, Zhu L, Gu R, Xu H, et al. Macular Perfusion in Healthy Chinese: An Optical Coherence Tomography Angiogram Study. Investig Opthalmology Vis Sci. 2015 May 21;56(5):3212.

25. Bazvand F, Mirshahi R, Fadakar K, Faghihi H, Sabour S, Ghassemi F. The Quantitative Measurements of Vascular Density and Flow Area of Optic Nerve Head Using Optical Coherence Tomography Angiography: J Glaucoma. 2017 Aug;26(8):735–41. doi: 10.1097/IJG.0000000000000722 28692595

26. Wang X, Kong X, Jiang C, Li M, Yu J, Sun X. Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study. BMJ Open. 2016;6(3):e010791. doi: 10.1136/bmjopen-2015-010791 26969645

27. Al-Sheikh M, Phasukkijwatana N, Dolz-Marco R, Rahimi M, Iafe NA, Freund KB, et al. Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes. Investig Opthalmology Vis Sci. 2017 Apr 7;58(4):2063.

28. Wang Q, Chan S, Yang JY, You B, Wang YX, Jonas JB, et al. Vascular Density in Retina and Choriocapillaris as Measured by Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016 Aug;168:95–109. doi: 10.1016/j.ajo.2016.05.005 27183862

29. Hassan M, Sadiq MA, Halim MS, Afridi R, Soliman MK, Sarwar S, et al. Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography. Int J Retina Vitr [Internet]. 2017 Dec [cited 2018 Feb 18];3(1). Available from: http://journalretinavitreous.biomedcentral.com/articles/10.1186/s40942-017-0080-0

30. Coscas F, Sellam A, Glacet-Bernard A, Jung C, Goudot M, Miere A, et al. Normative Data for Vascular Density in Superficial and Deep Capillary Plexuses of Healthy Adults Assessed by Optical Coherence Tomography Angiography. Investig Opthalmology Vis Sci. 2016 Jul 13;57(9):OCT211.

31. Jia Y, Bailey ST, Wilson DJ, Tan O, Klein ML, Flaxel CJ, et al. Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration. Ophthalmology. 2014 Jul;121(7):1435–44. doi: 10.1016/j.ophtha.2014.01.034 24679442

32. Ting DSW, Tan GSW, Agrawal R, Yanagi Y, Sie NM, Wong CW, et al. Optical Coherence Tomographic Angiography in Type 2 Diabetes and Diabetic Retinopathy. JAMA Ophthalmol. 2017 Apr 1;135(4):306. doi: 10.1001/jamaophthalmol.2016.5877 28208170

33. Sugahara M, Miyata M, Ishihara K, Gotoh N, Morooka S, Ogino K, et al. Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa. Sci Rep. 2017 Apr 13;7:46396. doi: 10.1038/srep46396 28406171

34. Manalastas PIC, Zangwill LM, Saunders LJ, Mansouri K, Belghith A, Suh MH, et al. Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes: J Glaucoma. 2017 Oct;26(10):851–9. doi: 10.1097/IJG.0000000000000768 28858159

35. Lee J, Moon BG, Cho AR, Yoon YH. Optical Coherence Tomography Angiography of DME and Its Association with Anti-VEGF Treatment Response. Ophthalmology. 2016 Nov;123(11):2368–75. doi: 10.1016/j.ophtha.2016.07.010 27613201

36. Agemy SA, Scripsema NK, Shah CM, Chui T, Garcia PM, Lee JG, et al. Retinal vascular perfusion density mapping using optical coherence tomography angiography in normals and diabetic retinopathy patients. Retina. 2015;35(11):2353–2363. doi: 10.1097/IAE.0000000000000862 26465617

37. Dimitrova G, Chihara E, Takahashi H, Amano H, Okazaki K. Quantitative retinal optical coherence tomography angiography in patients with diabetes without diabetic retinopathy. Invest Ophthalmol Vis Sci. 2017;58(1):190–196. doi: 10.1167/iovs.16-20531 28114579

38. Couturier A, Mané V, Bonnin S, Erginay A, Massin P, Gaudric A, et al. Capillary plexus anomalies in diabetic retinopathy on optical coherence tomography angiography. Retina. 2015;35(11):2384–2391. doi: 10.1097/IAE.0000000000000859 26469531

39. Hasegawa N, Nozaki M, Takase N, Yoshida M, Ogura Y. New Insights Into Microaneurysms in the Deep Capillary Plexus Detected by Optical Coherence Tomography Angiography in Diabetic Macular Edema. Investig Opthalmology Vis Sci. 2016 Jul 13;57(9):OCT348.

40. Ishibazawa A, Nagaoka T, Takahashi A, Omae T, Tani T, Sogawa K, et al. Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study. Am J Ophthalmol. 2015 Jul;160(1):35–44.e1. doi: 10.1016/j.ajo.2015.04.021 25896459

41. de Carlo TE, Chin AT, Bonini Filho MA, Adhi M, Branchini L, Salz DA, et al. DETECTION OF MICROVASCULAR CHANGES IN EYES OF PATIENTS WITH DIABETES BUT NOT CLINICAL DIABETIC RETINOPATHY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina Phila Pa. 2015 Nov;35(11):2364–70.

42. Freiberg FJ, Pfau M, Wons J, Wirth MA, Becker MD, Michels S. Optical coherence tomography angiography of the foveal avascular zone in diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2016 Jun;254(6):1051–8. doi: 10.1007/s00417-015-3148-2 26338819

43. Simonett JM, Scarinci F, Picconi F, Giorno P, De Geronimo D, Di Renzo A, et al. Early microvascular retinal changes in optical coherence tomography angiography in patients with type 1 diabetes mellitus. Acta Ophthalmol (Copenh). 2017 Dec;95(8):e751–5.

44. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013 Nov 27;310(20):2191–4. doi: 10.1001/jama.2013.281053 24141714

45. National Health Interview Survey Glossary [Internet]. Centers for Disease Control and Prevention; 2017. Available from: https://www.cdc.gov/nchs/nhis/tobacco/tobacco_glossary.htm

46. Garrity ST, Iafe NA, Phasukkijwatana N, Chen X, Sarraf D. Quantitative Analysis of Three Distinct Retinal Capillary Plexuses in Healthy Eyes Using Optical Coherence Tomography Angiography. Investig Opthalmology Vis Sci. 2017 Oct 26;58(12):5548.

47. Dumser SM, Ratcliffe SJ, Langdon DR, Murphy KM, Lipman TH. Racial disparities in screening for diabetic retinopathy in youth with type 1 diabetes. Diabetes Res Clin Pract. 2013 Jul;101(1):e3–5. doi: 10.1016/j.diabres.2013.03.009 23642967

48. Scott AW, Bressler NM, Ffolkes S, Wittenborn JS, Jorkasky J. Public Attitudes About Eye and Vision Health. JAMA Ophthalmol. 2016 Oct 1;134(10):1111–8. doi: 10.1001/jamaophthalmol.2016.2627 27490785

49. Hietala K, Forsblom C, Summanen P, Groop P-H, on behalf of the FinnDiane Study Group. Heritability of Proliferative Diabetic Retinopathy. Diabetes. 2008 Aug 1;57(8):2176–80. doi: 10.2337/db07-1495 18443200

50. Uhlmann K, Kovacs P, Boettcher Y, Hammes H-P, Paschke R. Genetics of Diabetic Retinopathy. Exp Clin Endocrinol Diabetes. 2006 Jul 26;114(06):275–94.

51. Gao X, Gauderman WJ, Marjoram P, Torres M, Chen Y-DI, Taylor KD, et al. Native American Ancestry Is Associated With Severe Diabetic Retinopathy in Latinos. Investig Opthalmology Vis Sci. 2014 Sep 24;55(9):6041.

52. Tandon A, Chen CJ, Penman A, Hancock H, James M, Husain D, et al. African Ancestry analysis and admixture genetic mapping for proliferative diabetic retinopathy in African Americans. Invest Ophthalmol Vis Sci. 2015;56(6):3999–4005. doi: 10.1167/iovs.15-16674 26098467

53. Yu D-Y, Cringle SJ, Alder V, Su E-N. Intraretinal oxygen distribution in the rat with graded systemic hyperoxia and hypercapnia. Invest Ophthalmol Vis Sci. 1999;40(9):2082–2087. 10440264

54. Yu D-Y, Cringle SJ, Paula KY, Su E-N. Intraretinal oxygen distribution and consumption during retinal artery occlusion and graded hyperoxic ventilation in the rat. Invest Ophthalmol Vis Sci. 2007;48(5):2290–2296. doi: 10.1167/iovs.06-1197 17460293

55. Campbell JP, Zhang M, Hwang TS, Bailey ST, Wilson DJ, Jia Y, et al. Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography. Sci Rep. 2017 Feb 10;7:42201. doi: 10.1038/srep42201 28186181

56. Nesper PL, Roberts PK, Onishi AC, Chai H, Liu L, Jampol LM, et al. Quantifying Microvascular Abnormalities With Increasing Severity of Diabetic Retinopathy Using Optical Coherence Tomography Angiography. Investig Opthalmology Vis Sci. 2017 Oct 23;58(6):BIO307.

57. Dimitrova G, Kato S, Tamaki Y, Yamashita H, Nagahara M, Sakurai M, et al. Choroidal circulation in diabetic patients. Eye. 2001;15(5):602.

58. Sohn EH, van Dijk HW, Jiao C, Kok PHB, Jeong W, Demirkaya N, et al. Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc Natl Acad Sci. 2016 May 10;113(19):E2655–64. doi: 10.1073/pnas.1522014113 27114552

59. Scarinci F, Jampol LM, Linsenmeier RA, Fawzi AA. Association of Diabetic Macular Nonperfusion With Outer Retinal Disruption on Optical Coherence Tomography. JAMA Ophthalmol. 2015 Sep 1;133(9):1036. doi: 10.1001/jamaophthalmol.2015.2183 26158562

60. Weiter JJ, Delori FC, Wing GL, Fitch KA. Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci. 1986 Feb;27(2):145–52. 3943941

61. Yiu G, Vuong VS, Oltjen S, Cunefare D, Farsiu S, Garzel L, et al. Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5764–71. doi: 10.1167/iovs.16-20070 27792810

62. Adini I, Adini A, Bazinet L, Watnick RS, Bielenberg DR, D’Amato RJ. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB J Off Publ Fed Am Soc Exp Biol. 2015 Feb;29(2):662–70.

63. Linderman R, Salmon AE, Strampe M, Russillo M, Khan J, Carroll J. Assessing the Accuracy of Foveal Avascular Zone Measurements Using Optical Coherence Tomography Angiography: Segmentation and Scaling. Transl Vis Sci Technol. 2017 Jun;6(3):16. doi: 10.1167/tvst.6.3.16 28616362

64. Sampson DM, Gong P, An D, Menghini M, Hansen A, Mackey DA, et al. Axial Length Variation Impacts on Superficial Retinal Vessel Density and Foveal Avascular Zone Area Measurements Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2017 01;58(7):3065–72. doi: 10.1167/iovs.17-21551 28622398

65. Hwang TS, Zhang M, Bhavsar K, Zhang X, Campbell JP, Lin P, et al. Visualization of 3 Distinct Retinal Plexuses by Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy. JAMA Ophthalmol. 2016 Dec 1;134(12):1411–9. doi: 10.1001/jamaophthalmol.2016.4272 27812696

66. Fields KE, Fields BJ. Racecraft: the soul of inequality in American life. London: Verso; 2014. 304 p.


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