Efficacy of cotrimoxazole (Sulfamethoxazole-Trimethoprim) as a salvage therapy for the treatment of bone and joint infections (BJIs)
Autoři:
Laurene Deconinck aff001; Aurélien Dinh aff001; Christophe Nich aff002; Thomas Tritz aff003; Morgan Matt aff001; Olivia Senard aff001; Simon Bessis aff001; Thomas Bauer aff004; Martin Rottman aff005; Jérome Salomon aff001; Frédérique Bouchand aff006; Benjamin Davido aff001
Působiště autorů:
Service des Maladies Infectieuses, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP, Garches, France
aff001; Service d’Orthopédie, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP, Garches, France
aff002; Pharmacie Hospitalière, Centre Hospitalier Universitaire Ambroise Paré, AP-HP, Boulogne-Billancourt, France
aff003; Service d’Orthopédie, Centre Hospitalier Universitaire Ambroise Paré, AP-HP, Boulogne-Billancourt, France
aff004; Laboratoire de Microbiologie, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP, Garches, France
aff005; Pharmacie Hospitalière, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP, Garches, France
aff006
Vyšlo v časopise:
PLoS ONE 14(10)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0224106
Souhrn
Introduction
Cotrimoxazole (Sulfamethoxazole-Trimethoprim, SXT) has interesting characteristics for the treatment of bone and joint infection (BJI): a broad spectrum of activity with adequate bone diffusion and oral and intravenous formulations. However, its efficacy and safety in BJIs are poorly documented and its use remains limited.
Methods
We conducted a retrospective study in 2 reference centers for BJIs from 2013 to 2018 among patients treated with SXT for a BJI. Data were collected from patient’s medical charts. Outcomes and adverse events were evaluated at day (D)7, D45 and D90.
Results
We analyzed 51 patients with a mean age of 60 ± 20 (SD) years of which 76% presented with an orthopedic device infection (ODI). Gram-negative bacilli (GNB) were involved in 47% of BJIs (n = 24). Moreover, they were often polymicrobial infections (41%). Doses of SXT ranged from 800/160mg bid (61%; n = 31) to 800/160mg tid (39%; n = 20). Median SXT treatment duration was 45 days (IQR 40–45). SXT was part of a dual therapy in 84% of patients (n = 43), associated mainly with fluoroquinolones (n = 17) or rifampicin (n = 14). Outcome was favorable at D7 in 98% (n = 50), at D45 in 88.2% (n = 45) and at D90 in 78.4% (n = 40). The second agent combined with SXT was not an independent factor of favorable outcome (p = 0.97). Adverse events were reported in 8% (n = 4) of patients, with a median of 21 days (IQR 20–30) from SXT initiation and led to discontinuation (n = 3).
Conclusion
SXT appears to be effective for treatment of BJIs as a salvage therapy, even in GNB or polymicrobial infection, including ODI. Further data are needed to confirm SXT efficacy as an alternative oral regimen in BJIs.
Klíčová slova:
Methicillin-resistant Staphylococcus aureus – Antibiotics – Adverse events – Surgical and invasive medical procedures – Enterobacteriaceae – Orthopedic surgery – Prosthetic device infections – Polymicrobial infections
Zdroje
1. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004;351: 1645–1654. doi: 10.1056/NEJMra040181 15483283
2. Darley ESR. Antibiotic treatment of Gram-positive bone and joint infections. J Antimicrob Chemother. 2004;53: 928–935. doi: 10.1093/jac/dkh191 15117932
3. Ferry T, Uçkay I, Vaudaux P, François P, Schrenzel J, Harbarth S, et al. Risk factors for treatment failure in orthopedic device-related methicillin-resistant Staphylococcus aureus infection. Eur J Clin Microbiol Infect Dis. 2010;29: 171–180. doi: 10.1007/s10096-009-0837-y 19946789
4. Senneville E, Joulie D, Legout L, Valette M, Dezeque H, Beltrand E, et al. Outcome and predictors of treatment failure in total hip/knee prosthetic joint infections due to Staphylococcus aureus. Clin Infect Dis. 2011;53: 334–340. doi: 10.1093/cid/cir402 21810745
5. Stengel D, Bauwens K, Sehouli J, Ekkernkamp A, Porzsolt F. Systematic review and meta-analysis of antibiotic therapy for bone and joint infections. Lancet Infect Dis. 2001;1: 175–188. doi: 10.1016/S1473-3099(01)00094-9 11871494
6. Lazzarini L, Lipsky BA, Mader JT. Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials? Int J Infect Dis. 2005;9: 127–138. doi: 10.1016/j.ijid.2004.09.009 15840453
7. Gentry LO, Rodriguez-Gomez G. Ofloxacin versus parenteral therapy for chronic osteomyelitis. Antimicrob Agents Chemother. 1991;35: 538–541. doi: 10.1128/aac.35.3.538 2039205
8. Karamanis EM, Matthaiou DK, Moraitis LI, Falagas ME. Fluoroquinolones versus beta-lactam based regimens for the treatment of osteomyelitis: a meta-analysis of randomized controlled trials. Spine (Phila Pa 1976). 2008;33: E297–304. doi: 10.1097/BRS.0b013e31816f6c22 18449029
9. Spellberg B, Lipsky BA. Systemic antibiotic therapy for chronic osteomyelitis in adults. Clin Infect Dis. 2012;54: 393–407. doi: 10.1093/cid/cir842 22157324
10. Titécat M, Senneville E, Wallet F, Dezèque H, Migaud H, Courcol R-J, et al. Bacterial epidemiology of osteoarticular infections in a referent center: 10-year study. Orthop Traumatol Surg Res OTSR. 2013;99: 653–658. doi: 10.1016/j.otsr.2013.02.011 23988422
11. Colodner R, Rock W, Chazan B, Keller N, Guy N, Sakran W, et al. Risk factors for the development of Extended-Spectrum Beta-Lactamase-producing bacteria in nonhospitalized patients. Eur J Clin Microbiol Infect Dis. 2004;23: 163–167. doi: 10.1007/s10096-003-1084-2 14986159
12. Tomé AM, Filipe A. Quinolones: review of psychiatric and neurological adverse reactions. Drug Saf. 2011;34: 465–488. doi: 10.2165/11587280-000000000-00000 21585220
13. Elwell LP, Wilson HR, Knick VB, Keith BR. In vitro and in vivo efficacy of the combination trimethoprim-sulfamethoxazole against clinical isolates of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1986;29: 1092–1094. doi: 10.1128/aac.29.6.1092 3488022
14. Kaka AS. Bactericidal activity of orally available agents against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 2006;58: 680–683. doi: 10.1093/jac/dkl283 16840428
15. Yeldandi V, Strodtman R, Lentino JR. In-vitro and in-vivo studies of trimethoprim-sulphamethoxazole against multiple resistant Staphylococcus aureus. J Antimicrob Chemother. 1988;22: 873–880. doi: 10.1093/jac/22.6.873 3266621
16. Burman LG. The antimicrobial activities of trimethoprim and sulfonamides. Scand J Infect Dis. 1986;18: 3–13. doi: 10.3109/00365548609032299 3515508
17. Saux MC, Le Rebeller A, Leng B, Mintrosse J. [Bone diffusion of trimethoprim and sulfamethoxazole high pressure liquid chromatography (HPLC) (author’s transl)]. Pathol Biol (Paris). 1982;30: 385–388.
18. Stein GE, Throckmorton JK, Scharmen AE, Weiss WJ, Prokai L, Smith CL, et al. Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection. J Antimicrob Chemother. 2013;68: 2852–2858. doi: 10.1093/jac/dkt267 23873647
19. Craven JL, Pugsley DJ, Blowers R. Trimethoprim-sulphamethoxazole in acute osteomyelitis due to penicillin-resistant staphylococci in Uganda. Br Med J. 1970;3: 201–203. doi: 10.1136/bmj.3.5716.201 5448781
20. Stein A, Bataille JF, Drancourt M, Curvale G, Argenson JN, Groulier P, et al. Ambulatory treatment of multidrug-resistant Staphylococcus-infected orthopedic implants with high-dose oral co-trimoxazole (trimethoprim-sulfamethoxazole). Antimicrob Agents Chemother. 1998;42: 3086–3091. 9835495
21. Seng P, Amrane S, Million M, Stein A. Old antimicrobials and Gram-positive cocci through the example of infective endocarditis and bone and joint infections. Int J Antimicrob Agents. 2017;49: 558–564. doi: 10.1016/j.ijantimicag.2017.03.004 28365430
22. Société de Pathologie Infectieuse de Langue Française (SPILF). Recommandations de pratique clinique, infections ostéo-articulaires sur matériel (prothèse, implant, ostéosynthèse) [Internet]. 2009. Available: http://www.infectiologie.com/UserFiles/File/medias/_documents/consensus/inf-osseuse-court.pdf
23. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52: e18–e55. doi: 10.1093/cid/ciq146 21208910
24. Gemmell CG, Edwards DI, Fraise AP, Gould FK, Ridgway GL, Warren RE. Guidelines for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the UK. J Antimicrob Chemother. 2006;57: 589–608. doi: 10.1093/jac/dkl017 16507559
25. Ho JM-W, Juurlink DN. Considerations when prescribing trimethoprim-sulfamethoxazole. Can Med Assoc J. 2011;183: 1851–1858. doi: 10.1503/cmaj.111152 21989472
26. Grammatico-Guillon L, Baron S, Gettner S, Lecuyer A-I, Gaborit C, Rosset P, et al. Bone and joint infections in hospitalized patients in France, 2008: clinical and economic outcomes. J Hosp Infect. 2012;82: 40–48. doi: 10.1016/j.jhin.2012.04.025 22738613
27. Fíca A, Lamas C, Olivares F, Ramírez D, Soto A, Porte L, et al. [Cotrimoxazole in bone-related infections: toxicity and clinical and economic impact]. Rev Chil Infectol Organo Of La Soc Chil Infectol. 2015;32: 609–617. doi: 10.4067/S0716-10182015000700001 26928496
28. Tornero E, Morata L, Martínez-Pastor JC, Angulo S, Combalia A, Bori G, et al. Importance of selection and duration of antibiotic regimen in prosthetic joint infections treated with debridement and implant retention. J Antimicrob Chemother. 2016;71: 1395–1401. doi: 10.1093/jac/dkv481 26929270
29. Euba G, Murillo O, Fernández-Sabé N, Mascaró J, Cabo J, Pérez A, et al. Long-term follow-up trial of oral rifampin-cotrimoxazole combination versus intravenous cloxacillin in treatment of chronic staphylococcal osteomyelitis. Antimicrob Agents Chemother. 2009;53: 2672–2676. doi: 10.1128/AAC.01504-08 19307354
30. Nguyen S, Pasquet A, Legout L, Beltrand E, Dubreuil L, Migaud H, et al. Efficacy and tolerance of rifampicin–linezolid compared with rifampicin–cotrimoxazole combinations in prolonged oral therapy for bone and joint infections. Clin Microbiol Infect. 2009;15: 1163–1169. doi: 10.1111/j.1469-0691.2009.02761.x 19438638
31. Harbarth S, von Dach E, Pagani L, Macedo-Vinas M, Huttner B, Olearo F, et al. Randomized non-inferiority trial to compare trimethoprim/sulfamethoxazole plus rifampicin versus linezolid for the treatment of MRSA infection. J Antimicrob Chemother. 2015;70: 264–272. doi: 10.1093/jac/dku352 25209610
32. Messina AF, Namtu K, Guild M, Dumois JA, Berman DM. Trimethoprim-sulfamethoxazole therapy for children with acute osteomyelitis. Pediatr Infect Dis J. 2011;30: 1019–1021. doi: 10.1097/INF.0b013e31822db658 21817950
33. Munckhof WJ, Kleinschmidt SL, Turnidge JD. Resistance development in community-acquired strains of methicillin-resistant Staphylococcus aureus: an in vitro study. Int J Antimicrob Agents. 2004;24: 605–608. doi: 10.1016/j.ijantimicag.2004.08.009 15555885
34. El Haj C, Murillo O, Ribera A, Lloberas N, Gómez-Junyent J, Tubau F, et al. Evaluation of linezolid or trimethoprim/sulfamethoxazole in combination with rifampicin as alternative oral treatments based on an in vitro pharmacodynamic model of staphylococcal biofilm. Int J Antimicrob Agents. 2018;51: 854–861. doi: 10.1016/j.ijantimicag.2018.01.014 29374577
35. Hsieh P, Lee MS, Hsu K, Chang Y, Shih H, Ueng SW. Gram‐Negative Prosthetic Joint Infections: Risk factors and outcome of treatment. Clin Infect Dis. 2009;49: 1036–1043. doi: 10.1086/605593 19691430
36. Campbell ML, Marchaim D, Pogue JM, Sunkara B, Bheemreddy S, Bathina P, et al. Treatment of methicillin-resistant Staphylococcus aureus infections with a minimal inhibitory concentration of 2 μg/mL to vancomycin: old (trimethoprim/sulfamethoxazole) versus new (daptomycin or linezolid) agents. Ann Pharmacother. 2012;46: 1587–1597. doi: 10.1345/aph.1R211 23212935
37. Fraser TN, Avellaneda AA, Graviss EA, Musher DM. Acute kidney injury associated with trimethoprim/sulfamethoxazole. J Antimicrob Chemother. 2012;67: 1271–1277. doi: 10.1093/jac/dks030 22351681
38. Gentry CA, Nguyen AT. An evaluation of hyperkalemia and serum creatinine elevation associated with different dosage levels of outpatient trimethoprim-sulfamethoxazole with and without concomitant medications. Ann Pharmacother. 2013;47: 1618–1626. doi: 10.1177/1060028013509973 24259630
39. Valour F, Karsenty J, Bouaziz A, Ader F, Tod M, Lustig S, et al. Antimicrobial-related severe adverse events during treatment of bone and joint infection due to methicillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2014;58: 746–755. doi: 10.1128/AAC.02032-13 24247130
40. Lee C-C, Lee MG, Hsieh R, Porta L, Lee W-C, Lee S-H, et al. Oral fluoroquinolone and the risk of aortic dissection. J Am Coll Cardiol. Elsevier; 2018;72: 1369–1378. doi: 10.1016/j.jacc.2018.06.067 30213330
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