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Using AST-platelet ratio index and fibrosis 4 index for detecting chronic hepatitis C in a large-scale community screening


Autoři: Yuan-Hung Kuo aff001;  Kwong-Ming Kee aff001;  Nien-Tzu Hsu aff001;  Jing-Houng Wang aff001;  Chang-Chun Hsiao aff002;  Yi Chen aff005;  Sheng-Nan Lu aff001
Působiště autorů: Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan aff001;  Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan aff002;  Biostatistics and Bioinformatics Center of Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan aff003;  Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan aff004;  Public Health Bureau, Tainan City Government, Tainan, Taiwan aff005;  Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan aff006
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222196

Souhrn

Background

Aspartate transaminase-platelet ratio index (APRI) and fibrosis 4 (FIB-4) are two non-invasive indexes to predict liver fibrosis in liver disease. This study was to use APRI and FIB-4 to detect chronic virus hepatitis in community screenings.

Methods

From 2004 to 2013, a series of community-based health screenings for residents aged 40 and older were held in Tainan city. APRI and FIB-4 of each participant were calculated and their association further analyzed with hepatitis status.

Results

We enrolled 180359 participants including 18726 (10.4%) hepatitis B virus (HBV), 13428 (7.4%) hepatitis C virus (HCV), 1337 (0.7%) HBV plus HCV and 146868 (81.5%) Non-HBV Non-HCV. The prevalence of chronic HCV increased with the elevation of APRI cut-offs or FIB-4 cut-offs (13.9%, 28.1%, 38.8%, 45.2%, to 49.9% in APRI≥0.3, 0.5, 0.7, 0.9,1.1, p<0.001 for the linear trend; or 15.8%, 26.4%, 34.4% to 39.7% in FIB-4≥1.75, 2.75, 3.5, 4.25, p<0.001). At the township level, APRI≥ 0.7 and FIB-4≥ 3.5 were highly correlated with HCV infection (r = 0.95, p<0.001 in APRI and r = 0.809, p<0.001 in FIB-4) and hepatocellular carcinoma (HCC) development (r = 0.894, p<0.001 in APRI and r = 0.804, p<0.001 in FIB-4), but not correlated with HBV infection.

Conclusions

Community screenings derived APRI or FIB-4 can identify patient subsets with increased of underlying HCV infection and risk of incident HCC.

Klíčová slova:

Hepatitis C virus – Hepatitis B virus – Liver diseases – Chronic hepatitis – Hepatocellular carcinoma – Taiwan – Liver fibrosis


Zdroje

1. McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology 2009;49: S45–55. doi: 10.1002/hep.22898 19399792

2. Chen HL, Lin LH, Hu FC, Lin WT, Yang YJ, Huang FC, et al. Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV. Gastroenterology. 2012;142(4):773–781. doi: 10.1053/j.gastro.2011.12.035 22198276

3. Ni YH, Chang MH, Jan CF, Hsu HY, Chen HL, Wu JF, et al. Continuing Decrease in Hepatitis B Virus Infection 30 Years After Initiation of Infant Vaccination Program in Taiwan. Clin Gastroenterol Hepatol. 2016;14(9):1324–1330. doi: 10.1016/j.cgh.2016.04.030 27155556

4. Ganem D, Prince AM. Hepatitis B virus infection natural history and clinical consequences. N Engl J Med 2004; 350(11):1118–29. doi: 10.1056/NEJMra031087 15014185

5. Hajarizadeh B, Grebely J, Dore GJ. Epidemiology and natural history of HCV infection. Nat Rev Gastroenterol Hepatol. 2013; 10(9):553–562. doi: 10.1038/nrgastro.2013.107 23817321

6. Nguyen LH, Nguyen MH. Systematic review: Asian patients with chronic hepatitis C infection. Aliment Pharmacol Ther. 2013; 37(10):921–936. doi: 10.1111/apt.12300 23557103

7. Lok AS, McMahon BJ, Brown RS Jr, Wong JB, Ahmed AT, Farah w, et al. Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis. Hepatology. 2016;63(1):284–306. doi: 10.1002/hep.28280 26566246

8. Papatheodoridis GV, Sypsa V, Dalekos G, Yurdaydin C, van Boemmel F, Buti M, et al. Eight-year survival in chronic hepatitis B patients under long-term entecavir or tenofovir therapy is similar to the general population. J Hepatol. 2018;68(6):1129–1136. doi: 10.1016/j.jhep.2018.01.031 29427727

9. Flemming JA, Kim WR, Brosgart CL, Terrault NA. Reduction in liver transplant wait-listing in the era of direct-acting antiviral therapy. Hepatology. 2017;65(3):804–812. doi: 10.1002/hep.28923 28012259

10. Ji F, Wei B, Yeo YH, Ogawa E, Zou B, Stave CD, et al. Systematic review with meta-analysis: effectiveness and tolerability of interferon-free direct-acting antiviral regimens for chronic hepatitis C genotype 1 in routine clinical practice in Asia. Aliment Pharmacol Ther. 2018;47(5):550–562. doi: 10.1111/apt.14507 29327780

11. Ranieri R, Starnini G, Carbonara S, Pontali E, Leo G, Romano A, et al. Management of HCV infection in the penitentiary setting in the direct-acting antivirals era: practical recommendations from an expert panel. Infection. 2017;45(2):131–138. doi: 10.1007/s15010-016-0973-0 28025726

12. Houot M, Ngo Y, Munteanu M, Marque S, Poynard T. Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Aliment Pharmacol Ther. 2016;43(1):16–29. doi: 10.1111/apt.13446 26516104

13. Xiao G, Yang J, Yan L. Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: a systemic review and meta-analysis. Hepatology. 2015;61(1):292–302. doi: 10.1002/hep.27382 25132233

14. Mansoor S, Collyer E, Alkhouri N. A comprehensive review of noninvasive liver fibrosis tests in pediatric nonalcoholic Fatty liver disease. Curr Gastroenterol Rep. 2015;17(6):23. doi: 10.1007/s11894-015-0447-z 26031832

15. Tung HD, Wang JH, Tseng PL, Hung CH, Kee KM, Chen CH, et al. Neither diabetes mellitus nor over- weight is a risk factor for hepatocellular carcinoma in a dual HBV and HCV endemic area: community cross-sectional and case-control studies. Am J Gastroenterol. 2010; 105(3):624–631. doi: 10.1038/ajg.2009.711 20051944

16. Chen JY, Wang JH, Lin CY, Chen PF, Tseng PL, Chen CH, et al. Lower prevalence of hypercholester- olemia and hyperglyceridemia found in subjects with seropositivity for both hepatitis B and C strains in- dependently. J Gastroenterol Hepatol. 2010; 25(11):1763–1768. doi: 10.1111/j.1440-1746.2010.06300.x 21039839

17. Liu JL, Chen JY, Chen CT, Wang JH, Lin CY, Chen PF, et al. Community-based cross-sectional study: the association of lipids with hepatitis C seropositivity and diabetes mellitus. J Gastroenterol Hepatol. 2012; 27(11):1688–1694. doi: 10.1111/j.1440-1746.2012.07212.x 22742891

18. Becker L, Salameh W, Sferruzza A, Zhang K, ng Chen R, Malik R, et al. Validation of hepascore, compared with simple indices of fibrosis, in patients with chronic hepatitis C virus infection in United States. Clin Gastroenterol Hepatol. 2009 Jun;7(6):696–701. 19514117

19. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology 2006;43: 1317–1325. doi: 10.1002/hep.21178 16729309

20. Wang JH, Chuah SK, Lu SN, Hung CH, Kuo CM, Tai WC, et al. Baseline and serial liver stiffness measurement in prediction of portal hypertension progression for patients with compensated cirrhosis. Liver Int. 2014 Oct;34(9):1340–1348. doi: 10.1111/liv.12525 24620731

21. Chen CL, Yang JY, Lin SF, Sun CA, Bai CH, You SL, et al. Slow decline of hepatitis B burden in general population: Results from a population-based survey and longitudinal follow-up study in Taiwan. J Hepatol. 2015;63(2):354–363. doi: 10.1016/j.jhep.2015.03.013 25795588

22. Kuo YH, Chen PF, Wang JH, Chang KC, Kee KM, Tsai Mc, et al. Comparison Stratagems of Post-Screening Management of Anti-HCV-Positive Community Residents: Simple Notification, Active Referral, or Accessible Medical Care. PLoS One. 2015;13;10(5):e0126031. doi: 10.1371/journal.pone.0126031 25970487

23. Liu J, Yang HI, Lee MH, Lu SN, Jen CL, Wang LY, et al., REVEALHBV Study Group. Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance: a community-based follow-up study. Gastroenterology 2010;139:474–482. doi: 10.1053/j.gastro.2010.04.048 20434450

24. Tai DI, Tsay PK, Chen WT, Chu CM, Liaw YF. Relative roles of HBsAg seroclearance and mortality in the decline of HBsAg prevalence with increasing age. Am J Gastroenterol 2010;105: 1102–1109. doi: 10.1038/ajg.2009.669 20197760

25. Tsai PS, Chang CJ, Chen KT, Chang KC, Hung SF, Wang JH, et al. Acquirement and disappearance of HBsAg and anti-HCV in an aged population: a follow-up study in an endemic township. Liver Int 2011;31:971–979. doi: 10.1111/j.1478-3231.2010.02363.x 21054768

26. Hajarizadeh B, Grebely J, Dore GJ. Epidemiology and natural history of HCV infection. Nat Rev Gastroenterol Hepatol. 2013;10(9):553–62. doi: 10.1038/nrgastro.2013.107 23817321

27. Su WW, Chen CH, Lin HH, Yang SS, Chang TT, Cheng KS, et al. Geographic variations of predominantly hepatitis C virus associated male hepatocellular carcinoma townships in Taiwan: identification of potential high HCV endemic areas. Hepatol Int. 2009;3(4):537–543. doi: 10.1007/s12072-009-9146-x 19669239


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