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Sociodemographic changes and trends in the rates of new perinatal HIV diagnoses and transmission in Spain from 1997 to 2015


Autoři: Santiago Jiménez de Ory aff001;  José Tomas Ramos aff002;  Claudia Fortuny aff003;  María Isabel González-Tomé aff004;  Maria José Mellado aff005;  David Moreno aff007;  César Gavilán aff009;  Ana Isabel Menasalvas aff011;  Ana Isabel Piqueras aff012;  M. Antoinette Frick aff013;  Maria Angeles Muñoz-Fernández aff016;  Maria Luisa Navarro aff018
Působiště autorů: Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IisGM), CoRISpe, Madrid, Spain aff001;  Servicio de Pediatría, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain aff002;  Unidad de Enfermedades Infecciosas, Servicio de Pediatría, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues del Llobregat, Spain aff003;  Servicio de Infecciosas Pediátricas, Hospital Universitario Doce de Octubre, Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain aff004;  Pediatrics, Immunodeficiencies and Infectious Diseases Unit, Hospital Universitario La Paz, Madrid, Spain aff005;  Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain aff006;  Department of Pediatrics, Regional Maternal-Child University Hospital, Malaga, Spain aff007;  IBIMA Multidisciplinary Group for Pediatric Research, Malaga, Spain, Malaga University, Malaga, Spain aff008;  Department of Paediatrics, University Clinical Hospital of San Juan de Alicante, San Juan de Alicante, Alicante, Spain aff009;  Department of Paediatrics, Miguel Hernández University of Elche, Campus of Sant Joan d'Alacant, Alicante, Spain aff010;  Department of Paediatrics, Hospital Virgen de la Arrixaca, Murcia, España aff011;  Department of Pediatric Surgery, and Department of Pediatrics, Hospital La Fe, Valencia, Spain aff012;  Tropical Medicine and International Health Unit. Hospital Universitari Vall d'Hebron, Barcelona, Spain aff013;  Department of Pediatrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain aff014;  PROSICS Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain aff015;  Section Immunology, Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain aff016;  Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain, Spanish HIV HGM BioBank, Madrid, Spain aff017;  Sección de Enfermedades Infecciosas, Servicio de Pediatría, Hospital General Universitario Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón, Medical School, Universidad Complutense de Madrid, Translational Research Network in Ped aff018
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0223536

Souhrn

Background

There are not enough nationwide studies on perinatal HIV transmission in connection with a combination of antiretroviral treatments in Spain. Our objectives were to study sociodemographic changes and trends in the rates of HIV diagnoses and perinatal transmission in Spain from 1997 to 2015.

Methods

A retrospective study using data from Spanish Paediatric HIV Network (CoRISpe) and Spanish Minimum Basic Data Set (MDBS) was performed. HIV- diagnosed children between 1997 and 2015 were selected. Sociodemographic, clinical and immunovirological data of HIV-infected children and their mothers were studied in four calendar periods (P1: 1997–2000; P2: 2001–2005; P3: 2006–2010; P4: 2011–2015). Rates of perinatal HIV diagnoses and transmission from 1997 to 2015 were calculated.

Results

A total of 532 HIV-infected children were included in this study. Of these children, 406 were Spanish (76.3%) and 126 immigrants (23.7%). A decrease in the number of HIV diagnoses, 203 (38.2%) children in the first (P1), 149 (28%) in the second (P2), 130 (24.4%) in the third (P3) and 50 (9.4%) in the fourth (P4) calendar periods was studied. The same decrease in the Spanish HIV-infected children (P1, 174 (46.6%), P2, 115 (30.8%), P3, 65 (17.4%) and P4, 19 (5.1%)) was monitored. However, an increase in the number of HIV diagnoses by sexual contact (P1: 0%; P2: 1.3%; P3: 4.6%; P4: 16%) was observed. The rates of new perinatal HIV diagnoses and perinatal transmission in Spanish children decreased from 0.167 to 0.005 per 100,000 inhabitants and 11.4% to 0.4% between 1997 and 2015, respectively.

Conclusions

A decline of perinatal HIV diagnoses and transmission was observed. However, an increase of teen-agers HIV diagnoses with sexual infection was studied. Public awareness campaigns directed to teen-agers are advisable to prevent HIV infection by sexual contact.

Klíčová slova:

Labor and delivery – Pregnancy – HIV diagnosis and management – Mothers – HIV epidemiology – Spain – Spanish people


Zdroje

1. World Health Organization (WHO)/HIV/AIDS Programme. Antiretroviral Therapy of HIV infection in Infants and Children: Towards universal access. Recommendations for a public health approach [WHO web site]. June 30, 2010. Available at: http://apps.who.int/iris/bitstream/10665/164255/1/9789241599801_eng.pdf?ua=1. Accesed February 15, 2019.

2. Luzuriaga K, Mofenson LM. Challenges in the Elimination of Pediatric HIV-1 Infection. N Engl J Med. 2016 Feb 25;374(8):761–70. doi: 10.1056/NEJMra1505256 26933850

3. Bamford A, Turkova A, Lyall H, Foster C, Klein N, Bastiaans D, et al. Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life. HIV Med. 2018;19(1):e1―e42. doi: 10.1111/hiv.12217 25649230

4. Bertie E, Thorne C, Noguera-Julian A, Rojo P, Galli L, de Martino M, et al. The new face of the paediatric HIV epidemic in Western countries: demographic characteristics, morbidity and mortality of the paediatric HIV-infected population. Pediat Infect Dis. J. 2015;34(5 Suppl 1):S7―13.

5. Guillén S, Prieto L, Jiménez de Ory S, González-Granado I, González-Tomé MI, Mellado MJ, et al. [New diagnosis of HIV infection in children]. Enferm Infecc Microbiol Clin. 2012 Mar;30(3):131–6. doi: 10.1016/j.eimc.2011.09.007 Epub 2011 Nov 25. Spanish. 22119095

6. Holgado-Juan M, Holgado-Juan MC, García-Ron MT, Esteban-Fernández FJ, Prieto-Tato LM, Ramos-Amador JT. [Characteristics of a cohort of pregnant women with human immunodeficiency virus infection]. Enferm Infecc Microbiol Clin. 2013 Mar;31(3):147–51. doi: 10.1016/j.eimc.2012.06.007 Epub 2012 Sep 1. Spanish. 22943833

7. Prieto LM, González-Tomé MI, Muñoz E, Fernández-Ibieta M, Soto B, Del Rosal T, et al. Low rates of mother-to-child transmission of HIV-1 and risk factors for infection in Spain: 2000–2007. Pediatr Infect Dis J. 2012 Oct;31(10):1053–8. doi: 10.1097/INF.0b013e31826fe968 22926219

8. Rojano I Luque X, Almeda Ortega J, Sánchez Ruiz E, Fortuny I Guasch C, Bertrán I Sanguès JM, Mur Sierra A, et al. [Trends of HIV mother-to-child transmission in Catalonia, Spain, between 1987 and 2003]. Med Clin (Barc). 2007 Oct 13;129(13):487–93. Spanish.

9. Soriano-Arandes A, Noguera-Julian A, Fortuny C; NENEXP Cohort Study Group. Impact of immigration on HIV mother-to-child transmission in Western Europe. HIV Med. 2017 Aug;18(7):532–533. doi: 10.1111/hiv.12482 Epub 2016 Dec 30. 28035766

10. Epidemiological surveillance of HIV/AIDS in Spain. Update 30 June 2018; Spanish Ministry of Health, Consumer Affairs and Social Welfare website. Available at: https://www.mscbs.gob.es/ciudadanos/enfLesiones/enfTransmisibles/sida/vigilancia/home.htm. Accessed February 15, 2019.

11. de Jose MI, Jiménez de Ory S, Espiau M, Fortuny C, Navarro ML, Soler-Palacín P, et al. A new tool for the paediatric HIV research: general data from the Cohort of the Spanish Paediatric HIV Network (CoRISpe). BMC Infect Dis. 2013;13:2. doi: 10.1186/1471-2334-13-2 23282073

12. García-Merino I, de Las Cuevas N, Jiménez JL, García A, Gallego J, Gómez C, et al. Pediatric HIV BioBank: a new role of the Spanish HIV BioBank in pediatric HIV research. AIDS Res Hum Retroviruses. 2010;26(2):241―244. doi: 10.1089/aid.2009.0122 20156108

13. Jiménez de Ory S, González-Tomé MI, Fortuny C, Mellado MJ, Soler-Palacin P, Bustillo M, et al. New diagnoses of human immunodeficiency virus infection in the Spanish pediatric HIV Cohort (CoRISpe) from 2004 to 2013. Medicine (Baltimore). 2017;96(39):e7858.

14. Subdirección General de Información Sanitaria e Innovación. Registro de Actividad de Atención Especializada. RAE-CMBD. Available at: https://www.mscbs.gob.es/en/estadEstudios/estadisticas/cmbdhome.htm. Accessed February 15, 2019.

15. 2010 ICD-9-CM Diagnosis Codes. Available at: http://www.icd9data.com/. Accessed February 15, 2019.

16. CDC. 1994 Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR 1994; 43(No. RR-12).

17. Spanish Statistical Office (INE). Population figures 2015. [INE web site] Available at: http://www.ine.es/dyngs/INEbase/en/operacion.htm?c=Estadistica_C&cid=1254736176951&menu=resultados&idp=1254735572981. Accessed February 15, 2019.

18. European Centre for Disease Prevention and Control/WHO Regional Office for Europe. HIV/AIDS surveillance in Europe 2018–2017 data [ECDC web site]. Available at: https://ecdc.europa.eu/en/publications-data/hivaids-surveillance-europe-2018-2017-data. Accesed July 15, 2019.

19. Cohen S, van Bilsen WP, Smit C, Fraaij PL, Warris A, Kuijpers TW, et al. Country of birth does not influence long-term clinical, virological, and immunological outcome of HIV-infected children living in the Netherlands: a cohort study comparing children born in the Netherlands with children born in Sub-Saharan Africa. J Acquir Immune Defic Syndr. 2015;68(2):178―185. doi: 10.1097/QAI.0000000000000431 25405830

20. Del Amo J, Likatavičius G, Pérez-Cachafeiro S, Hernando V, González C, Jarrín I, et al. The epidemiology of HIV and AIDS reports in migrants in the 27 European Union countries, Norway and Iceland: 1999–2006. Eur J Public Health. 2011;21(5):620―626. doi: 10.1093/eurpub/ckq150 21051469

21. Gemma R, Martínez JM, García AM, Benavides FG, Ronda E. From the boom to the crisis: changes in employment conditions of immigrants in Spain and their effects on mental health. Eur J Public Health. 2014;3:404―409.

22. Velo-Higueras C, Cuéllar-Flores I, Sainz-Costa T, Navarro-Gómez ML, García-Navarro C, Fernández-McPhee C, et al. Young adults and HIV. Awareness and risk behaviour of a group living in Spain. Enferm Infecc Microbiol Clin. 2019 Mar;37(3):176–182. [Article in English, Spanish]. doi: 10.1016/j.eimc.2018.05.015 30017259

23. Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, van Lunzen J, et al. Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. JAMA. 2016;316:171–81, 12. doi: 10.1001/jama.2016.5148 27404185

24. González-Baeza A, Dolengevich-Segal H, Pérez-Valero I, Cabello A, Téllez MJ, Sanz J, et al. Sexualized drug use (Chemsex) is associated with high-risk sexual behaviors and sexually transmitted infections in HIV-positive men who have sex with men: Data from the U-SEX GESIDA 9416 Study. AIDS Patient Care STDS. 2018;32:112–8. doi: 10.1089/apc.2017.0263 29620925

25. Centers for Disease Control and Prevention. Sexual Risk Behaviors: HIV, STD, & Teen Pregnancy Prevention. 2017.

26. Amy L. Slogrove et al. Living and dying to be counted: What we know about the epidemiology of the global adolescent HIV epidemic. J Int AIDS Soc. 2017, 20(Suppl 3):21520. doi: 10.7448/IAS.20.4.21520 28530036

27. The Ministry of Health, Consumer Affairs and Social Welfare. Consensus document of Gesida/Secretariat of the National AIDS Plan with respect to antiretroviral therapy in adults infected with human immunodeficiency virus. (Ministry of Health, Social Services and Equality web site). 2013. Available at: http://gesida-seimc.org/wp-content/uploads/2019/02/Guia_Tar_Gesida_Ene_2019.pdf. Accessed February 15, 2019.

28. Recommendations of the Secretaria of the National AIDS Plan (SNAP), the Study Group of Aids SGA), the Spanish Society of Gynecology and Obstetrics (SSGO) and the Spanish Association of Pediatrics (SAP) for monitoring infection by HIV in relation to the reproduction, pregnancy and the prevention of vertical transmission. Ministry of Health, Social Services and Equality website. Available at: https://www.mscbs.gob.es/ciudadanos/enfLesiones/enfTransmisibles/sida/publicaciones/profSanitarios/DocEmbarazoMarzo2013.pdf. Accessed February 15, 2019.

29. Aceijas C, Stimson GV, Hickman M, Rhodes T; United Nations Reference Group on HIV/AIDS Prevention and Care among IDU in Developing and Transitional Countries. Global overview of injecting drug use and HIV infection among injecting drug users. AIDS. 2004 Nov 19;18(17):2295–303. doi: 10.1097/00002030-200411190-00010 15577542

30. Townsend CL, Cortina-Borja M, Peckham CS, de Ruiter A, Lyall H, Tookey PA. Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000–2006. AIDS. 2008 May 11;22(8):973–81. doi: 10.1097/QAD.0b013e3282f9b67a 18453857

31. Navér L, Lindgren S, Belfrage E, Gyllensten K, Lidman K, Gisslén M, et al. Children born to HIV-1-infected women in Sweden in 1982–2003: trends in epidemiology and vertical transmission. J Acquir Immune Defic Syndr. 2006 Aug 1;42(4):484–9. doi: 10.1097/01.qai.0000224571.30119.3d 16810115

32. Taylor AW, Nesheim SR, Zhang X, Song R, FitzHarris LF, Lampe MA, et al. Estimated perinatal HIV infection among infants born in the United States, 2002–2013. JAMA Pediatr. 2017 May 1;171(5):435–442. doi: 10.1001/jamapediatrics.2016.5053 28319246

33. Galli L, Puliti D, Chiappini E, Gabiano C, Tovo PA, Pezzotti P, et al. Lower mother-to-child HIV-1 transmission in boys is independent of type of delivery and antiretroviral prophylaxis: the Italian Register for HIV Infection in Children. J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):479–85. doi: 10.1097/01.qai.0000164247.49098.0e 16280705

34. von Linstow ML, Rosenfeldt V, Lebech AM, Storgaard M, Hornstrup T, Katzenstein TL, et al. Prevention of mother-to-child transmission of HIV in Denmark, 1994–2008. HIV Med. 2010 Aug;11(7):448–56. doi: 10.1111/j.1468-1293.2009.00811.x 20146735

35. Warszawski J, Tubiana R, Le Chenadec J, Blanche S, Teglas JP, Dollfus C, et al. Mother-to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort. AIDS. 2008 Jan 11;22(2):289–99. doi: 10.1097/QAD.0b013e3282f3d63c 18097232

36. World Health Organization (WHO)/Human reproduction programme. Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV and Syphilis. [WHO web site]. 2017. Available at: https://www.who.int/reproductivehealth/congenital-syphilis/WHO-validation-MTCT/en/. Accesed July 15, 2019.

37. Committee on Pediatric AIDS, Emmanuel PJ, Martinez J. Adolescents and HIV infection: the pediatrician's role in promoting routine testing. Pediatrics. 2011 Nov;128(5):1023–9. doi: 10.1542/peds.2011-1761 22042816


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