Frequency and distribution of corneal astigmatism and keratometry features in adult life: Methodology and findings of the UK Biobank study

English version

Autoři: Nikolas Pontikos ^aff001; Sharon Chua ^aff001; Paul J. Foster ^aff001; Stephen J. Tuft ^aff001; Alexander C. Day ^aff001;
Působiště autorů: UCL Institute of Ophthalmology, London, England, United Kingdom ^aff001; NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, England, United Kingdom ^aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0218144

Souhrn

Purpose

To describe corneal astigmatism in the UK Biobank population and to look for associations with other biometric variables and socio-demographic factors.

Methods

This analysis included a subsample of 107,452 participants of the UK Biobank study who underwent an enhanced ophthalmic examination including autorefractor keratometry (Tomey RC 5000, Tomey Corp., Nagoya, Japan). Participants were recruited from across the United Kingdom between 2006 and 2010, and all were between 40 to 69 years. After quality control and applying relevant exclusions, data on corneal astigmatism on 83,751 participants were included for analysis. Potential associations were tested through univariable regression and significant parameters carried forward for multivariable analysis.

Results

In univariable analysis, the characteristics significantly associated with higher corneal astigmatism (P<0.001), by order of magnitude were, female gender, white ethnicity, lighter skin colour, use of UV protection, lower alcohol intake, lower corneal-compensated intraocular pressure (ccIOP), older age at completion of education, younger age, higher Townsend deprivation index, lower height and lower systolic blood pressure. After inclusion in the multivariable analysis, gender, skin colour, alcohol intake, age at completion of full-time education, ccIOP, age and Townsend deprivation score remained significant (all P<0.001). Increased corneal astigmatism was also found to be significantly associated with amblyopia or strabismus.

Conclusions

This analysis confirms previous associations with astigmatism such as younger age and female gender, and identified novel risk factors including lighter skin colour, lower alcohol intake, later age having completed full time education later, lower ccIOP and higher Townsend deprivation index. Further research is needed to investigate these novel associations.

Klíčová slova:

Biology and life sciences – Research and analysis methods – People and places – Population groupings – Anatomy – Medicine and health sciences – Nutrition – Diet – Alcohol consumption – Head – Age groups – Surgical and invasive medical procedures – Ophthalmology – Eye diseases – Eyes – Ocular system – Ocular anatomy – Chemical characterization – Ethnicities – Cornea – Ophthalmic procedures – Cataract surgery – Optical analysis – Refractive index

Zdroje

1. Bourne RRA, Stevens GA, White RA, Smith JL, Flaxman SR, Price H, et al. Causes of vision loss worldwide, 1990–2010: A systematic analysis. Lancet Glob Heal. 2013;

2. Hashemi H, Fotouhi A, Yekta A, Pakzad R, Ostadimoghaddam H, Khabazkhoob M. Global and regional estimates of prevalence of refractive errors: Systematic review and meta-analysis. Journal of Current Ophthalmology. 2018.

3. Morlet N, Minassian D, Dart J. Astigmatism and the analysis of its surgical correction. The British journal of ophthalmology. 2002.

4. Hirsch MJ. Changes in astigmatism after the age of forty. Optom Vis Sci. 1959;

5. Attebo K, Ivers RQ, Mitchell P. Refractive errors in an older population: The Blue Mountains Eye Study. Ophthalmology. 1999;

6. Hayashi K, Hayashi H, Hayashi F. Topographic Analysis of the Changes in Corneal Shape Due to Aging. Cornea. 1995;

7. Riley AF, Grupcheva CN, Malik TY, Craig JP, McGhee CNJ. The Auckland Cataract Study: Demographic, corneal topographic and ocular biometric parameters. Clin Exp Ophthalmol. 2001;

8. Ho JD, Liou SW, Tsai RJF, Tsai CY. Effects of aging on anterior and posterior corneal astigmatism. Cornea. 2010;

9. Mohammadi M, Naderan M, Pahlevani R, Jahanrad A. Prevalence of corneal astigmatism before cataract surgery. Int Ophthalmol. 2016;

10. Hoffer KJ. Biometry of 7,500 cataractous eyes. Am J Ophthalmol. 1980;

11. Hoffmann PC, Hütz WW. Analysis of biometry and prevalence data for corneal astigmatism in 23 239 eyes. J Cataract Refract Surg. 2010;

12. Khan MI, Muhtaseb M. Prevalence of corneal astigmatism in patients having routine cataract surgery at a teaching hospital in the United Kingdom. J Cataract Refract Surg. 2011;

13. Verhoeven VJM, Hysi PG, Saw SM, Vitart V, Mirshahi A, Guggenheim JA, et al. Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Hum Genet. 2012;

14. Ollier W, Sprosen T, Peakman T. UK Biobank: From concept to reality. Pharmacogenomics. 2005;

15. Palmer LJ. UK Biobank: bank on it. Lancet. 2007.

16. Allen N, Sudlow C, Downey P, Peakman T, Danesh J, Elliott P, et al. UK Biobank: Current status and what it means for epidemiology. Heal Policy Technol. 2012;

17. Cumberland PM, Bao Y, Hysi PG, Foster PJ, Hammond CJ, Rahi JS. Frequency and distribution of refractive error in adult life: Methodology and findings of the UK biobank study. PLoS One. 2015;

18. Ueno Y, Hiraoka T, Beheregaray S, Miyazaki M, Ito M, Oshika T. Age-Related Changes in Anterior, Posterior, and Total Corneal Astigmatism. J Refract Surg. 2014;

19. Yu JG, Zhong J, Mei ZM, Zhao F, Tao N, Xiang Y. Evaluation of biometry and corneal astigmatism in cataract surgery patients from Central China. BMC Ophthalmol. 2017;

20. Jonas JB, Kling F, Grundler AE. Optic disc shape, corneal astigmatism, and amblyopia. Ophthalmology. 1997;

21. Harvey EM. Development and treatment of astigmatism-related amblyopia. Optometry and Vision Science. 2009.

22. Oh EH, Kim H, Lee HS, Hwang KY, Joo CK. Analysis of anterior corneal astigmatism before cataract surgery using power vector analysis in eyes of Korean patients Presented in part at the 110th annual meeting of the Korean Ophthalmological Society, Seoul, South Korea, November 2013. J Cataract Refract Surg [Internet]. 2015 Jun [cited 2019 Aug 11];41(6):1256–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26189381 doi: 10.1016/j.jcrs.2014.09.043 26189381

23. Yuan X, Song H, Peng G, Hua X, Tang X. Prevalence of corneal astigmatism in patients before cataract surgery in Northern China. J Ophthalmol. 2014;

24. Curragh DS, Hassett P. Prevalence of corneal astigmatism in an NHS cataract surgery practice in Northern Ireland. Ulster Med J. 2017;

25. Day AC, Dhariwal M, Keith MS, Ender F, Perez Vives C, Miglio C, et al. Distribution of preoperative and postoperative astigmatism in a large population of patients undergoing cataract surgery in the UK. Br J Ophthalmol. 2019;

26. Schuster AKG, Pfeiffer N, Schulz A, Hoehn R, Ponto KA, Wild PS, et al. Refractive, corneal and ocular residual astigmatism: distribution in a German population and age-dependency—the Gutenberg health study. Graefe’s Arch Clin Exp Ophthalmol. 2017;

27. Shah RL, Li Q, Zhao W, Tedja MS, Tideman JWL, Khawaja AP, et al. A genome-wide association study of corneal astigmatism: The CREAM Consortium. Mol Vis. 2018;

28. Hofman A, Breteler MMB, Van Duijn CM, Krestin GP, Pols HA, Stricker BHC, et al. The Rotterdam Study: Objectives and design update. Eur J Epidemiol. 2007;

29. Saw SM, Shankar A, Tan SB, Taylor H, Tan DTH, Stone RA, et al. A cohort study of incident myopia in Singaporean children. Investig Ophthalmol Vis Sci. 2006;

30. Hofman A, Brusselle GGO, Murad SD, van Duijn CM, Franco OH, Goedegebure A, et al. The Rotterdam Study: 2016 objectives and design update. Eur J Epidemiol. 2015;

31. R. L, V.S.E. J, Y. Z, P. R, N. C, E.S. T, et al. Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: Quantifying ethnic variations in the epidemiology of eye diseases in Asians. Ophthalmic Epidemiol [Internet]. 2009;16(6):325–36. Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed12&NEWS=N&AN=355791759 doi: 10.3109/09286580903144738 19995197

32. Höhn R, Kottler U, Peto T, Blettner M, Münzel T, Blankenberg S, et al. The ophthalmic branch of the Gutenberg health study: Study design, cohort profile and self-reported diseases. PLoS One. 2015;

33. Schulze Schwering M, Kumar N, Bohrmann D, Msukwa G, Kalua K, Kayange P, et al. Refractive errors, visual impairment, and the use of low-vision devices in albinism in Malawi. Graefe’s Arch Clin Exp Ophthalmol. 2015;

34. Cooper J, Tkatchenko A V. A Review of Current Concepts of the Etiology and Treatment of Myopia. Eye Contact Lens. 2018;

35. Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, et al. Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nat Genet. 2018;

36. Hagishima M, Kamiya K, Fujimura F, Morita T, Shoji N, Shimizu K. Effect of corneal astigmatism on intraocular pressure measurement using ocular response analyzer and Goldmann applanation tonometer. Graefe’s Arch Clin Exp Ophthalmol. 2010;

37. Shah RL, Guggenheim JA. Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. Hum Genet. 2018