Molecular characterization of measles virus strains circulating in Cameroon during the 2013-2016 epidemics

English version

Autoři: Franck-Martin Obam Mekanda ^aff001; Chavely Gwladys Monamele ^aff001; Frédy Brice Simo Nemg ^aff001; Gilde Martial Yonga ^aff001; Diane Ouapi ^aff001; Véronique Penlap Beng ^aff002; Christophe Batéjat ^aff003; Valérie Caro ^aff003; Jean-Claude Manuguerra ^aff003; Maurice Demanou ^aff001
Působiště autorů: WHO National Measles Reference Laboratory, Department of Virology, Centre Pasteur of Cameroon (CPC), Yaoundé, Centre, Cameroon ^aff001; Faculty of Science, University of Yaoundé 1, Yaoundé, Centre, Cameroon ^aff002; Cellule d’Intervention Biologique d’Urgence (CIBU), Unité de Recherche et d’Expertise ‘Environnement et Risques Infectieux’ (ERI), Institut Pasteur, Paris, France ^aff003
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222428

Souhrn

The first genotyping data on measles virus (MeV) strains in Cameroon dates from 1994, while other studies were realized in 2001 and 2011 with the establishment of MeV virological surveillance. However, the genetic data of MeV strains circulating in Cameroon remains fragmented and concentrated in certain regions, hence the need for an update. The objective of this study was to have recent data on MeV genotypes circulating in Cameroon. Ninety throat swabs collected during recent measles outbreaks were analyzed by MeV genotyping RT-PCR using the nucleoprotein gene N. The resulting sequences were analyzed on the basis of 450 nucleotides with MEGA 7 software. Overall genome analysis was performed on 40/90 sequences. The strains were from all ten regions and all belonged to cluster 1 of genotype B3. The genotype B3 has been circulating in Cameroon for long periods of time; efforts must be made in immunization for its elimination.

Klíčová slova:

Phylogenetic analysis – Vaccines – RNA extraction – Reverse transcriptase-polymerase chain reaction – Genotyping – Measles virus – Cameroon – Measles

Zdroje

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Molecular characterization of measles virus strains circulating in Cameroon during the 2013-2016 epidemics

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