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The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study


Autoři: Junxi Liu aff001;  Shiu Lun Au Yeung aff001;  Baoting He aff001;  Man Ki Kwok aff001;  Gabriel Matthew Leung aff001;  C. Mary Schooling aff001
Působiště autorů: School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China aff001;  City University of New York Graduate School of Public Health and Health Policy, New York, New York, United States of America aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222141

Souhrn

Background

Lower birth weight is associated with diabetes although the underlying mechanisms are unclear. Muscle mass could be a modifiable link and hence a target of intervention. We assessed the associations of birth weight with muscle and fat mass observationally in a population with little socio-economic patterning of birth weight and using Mendelian randomization (MR) for validation.

Methods

In the population-representative “Children of 1997” birth cohort (n = 8,327), we used multivariable linear regression to assess the adjusted associations of birth weight (kg) with muscle mass (kg) and body fat (%) at ~17.5 years. Genetically predicted birth weight (effect size) was applied to summary genetic associations with fat-free mass and fat mass (kg) from the UK Biobank (n = ~331,000) to obtain unconfounded estimates using inverse-variance weighting.

Results

Observationally, birth weight was positively associated with muscle mass (3.29 kg per kg birth weight, 95% confidence interval (CI) 2.83 to 3.75) and body fat (1.09% per kg birth weight, 95% CI 0.54 to 1.65). Stronger associations with muscle mass were observed in boys than in girls (p for interaction 0.004). Using MR, birth weight was positively associated with fat-free mass (0.77 kg per birth weight z-score, 95% CI 0.22 to 1.33) and fat mass (0.58, 95% CI 0.01 to 1.15). No difference by sex was evident.

Conclusion

Higher birth weight increasing muscle mass may be relevant to lower birth weight increasing the risk of diabetes and suggests post-natal muscle mass as a potential target of intervention.

Klíčová slova:

Biology and life sciences – Genetics – Genomics – Genome analysis – Biochemistry – Computational biology – Research and analysis methods – People and places – Population groupings – Medicine and health sciences – Physiology – Genome-wide association studies – Human genetics – Physiological parameters – Women's health – Maternal health – Birth – Obstetrics and gynecology – Endocrinology – Endocrine disorders – Metabolic disorders – Body weight – Research design – Cohort studies – Lipids – Birth weight – Fats – Age groups – Children – Families


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