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Human papillomavirus infection among head and neck squamous cell carcinomas in southern China


Autoři: Guoying Ni aff001;  Kunsong Huang aff001;  Yi Luan aff003;  Zaizai Cao aff004;  Shu Chen aff003;  Bowei Ma aff001;  Jianwei Yuan aff001;  Xiaolian Wu aff003;  Guoqiang Chen aff003;  Tianfang Wang aff002;  Hejie Li aff002;  Shelley Walton aff005;  Fang Liu aff003;  Bobei Chen aff004;  Yuejian Wang aff003;  Xuan Pan aff001;  Xiaosong Liu aff001;  Ian H. Frazer aff006
Působiště autorů: The First Affiliated Hospital/Clinical Medical School, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China aff001;  Genecology Research Centre, University of the Sunshine Coast, Maroochydore DC, QLD, Australia aff002;  Cancer Research Institute, Foshan First People’s Hospital, Foshan, Guangdong, China aff003;  The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China aff004;  Inflammation and Healing Research Cluster, School of Health and Sport Sciences, University of Sunshine Coast, Maroochydore DC, QLD, Australia aff005;  The University of Queensland, Faculty of Medicine, Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia aff006
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0221045

Souhrn

Human papillomavirus (HPV) related tumours account for a significant proportion of head and neck squamous cell carcinomas (HNSCCs) in developed countries. They respond better to chemo- and radio-therapy, and have a better stage specific prognosis. To establish their prevalence in China, we assessed a series of histology confirmed HNSCCs collected in Zhejiang and Guangdong provinces by PCR for HPV DNA and by immunohistochemistry for p16 protein status. Among 303 HNSCCs, HPV DNA was detected in 26.4%, with HPV16 DNA in 71% of these. Of HNSCC located in the oropharynx, 38.55% (32/83) were HPV+ve. In this series, p16 status was a relatively poor predictor of HPV status as detected by PCR. The stage specific survival time of HPV+ HNSCCs was significantly longer than for HPV- HNSCC. HPV status should be assessed for oropharyngeal cancers in China to assist with appropriate management, and prophylaxis against HPV infection should be considered to reduce the incidence of this disease.

Klíčová slova:

Cancer treatment – Polymerase chain reaction – Human papillomavirus – Human papillomavirus infection – Cell staining – China – Head and neck squamous cell carcinoma – HPV-16


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