An analysis on HBsAg, Anti-HCV, Anti-HIV½ and VDRL test results in blood donors according to gender, age range and years

English version

Autoři: Canan Eren ^aff001
Působiště autorů: Marmara University Pendik Training and Research Hospital, Medical Microbiology and Blood Centre, Pendik, Istanbul ^aff001
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0219709

Souhrn

Objective

Blood transfusion is the most frequently used and life-saving therapeutic procedure today. Transmission of virus, bacteria and parasitic microorganisms may occur due to transfusion (Transfusion transmitted infections-TTIs). Hepatitis B and C, human immunodeficiency virus (HIV) and syphilis (Treponema pallidum) bear the risk of transmission by transfusion. Hepatitis B surface antigen (HBsAg), anti-HCV, anti-HIV½ and syphilis antibody (VDRL: Venereal Disease Research Laboratory) are routinely controlled in all donated blood samples. The aim of the present study was to analyze the seroprevalence rates of blood donors through screening test results according to duration, age range and gender.

Material and methods

Data of all blood donors obtained from blood Centre of Marmara University Pendik Training and Research Hospital between January 2013 and October 2018 were analyzed retrospectively. Serum samples of the donors were analyzed for HBsAg, anti-HCV, anti-HIV½ and VDRL. Test results of 114.240 donors were scanned. Gender, age range and distribution by years of these donors were analyzed. According to age distribution of donors were divided into 4 groups.

Results

There were 114.240 participants including 106.153 (92.9%) males and 8.087 (7.1%) females. The positivity rate of HBsAg was detected 0.4% (36/8087) in females and 0.5% (500/106.153) in males. The positivity rate of anti-HCV was detected 0.4% (32/8.087) in females and 0.3% (344/106.153) in males. The positivity rate of anti HIV½ was 0.1% (9/8.087) in females and 0.1% (92/106.153) in males whereas the positivity rate of VDRL was 0.5% (41/8.087) in females and 0.3% (362/ 106.153) in males. Positivity rate for HBsAg and HCV were lower in the cases between 18 and 30 years of age. The positivity rates for anti-HIV½ was not significantly different according to the age range. Positivity rate for VDRL was higher in the cases at 51 years of age and older.

Conclusion

No difference was found between men and women in terms of HBsAg, anti-HCV and anti-HIV½positivity. However, VDRL test positivity was significantly higher in female participants. Furthermore, HBsAg, anti-HCV and VDRL positivity rates increased by age.

Klíčová slova:

Biology and life sciences – Organisms – People and places – Population groupings – Anatomy – Medicine and health sciences – Microbiology – Medical microbiology – Microbial pathogens – Pathology and laboratory medicine – Pathogens – Physiology – Health care – Diagnostic medicine – Infectious diseases – Bacterial diseases – Tropical diseases – Viral pathogens – Immunodeficiency viruses – HIV – Retroviruses – Lentivirus – Viruses – RNA viruses – Body fluids – Blood – Urology – Hematology – Age groups – Genitourinary infections – Sexually transmitted diseases – Blood donors – Neglected tropical diseases – Serology – Blood counts – Syphilis – Treponematoses – Clinical laboratory sciences – Transfusion medicine – Blood transfusion

Zdroje

1. Seitz R, Heiden M. Quality and safety in blood supply in 2010. Transfus Med Hemother 2010;37:112–7. doi: 10.1159/000314497 20577599

2. Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet 2015;386:1546–55. doi: 10.1016/S0140-6736(15)61412-X 26231459

3. World Health Organization. Global Health Observatory HIV/AIDS. http://www.who.int/gho/hiv/en. Accessed 20 May 2016.

4. World Health Organization. Blood safety and availability. http://www.who.int/mediacentre/factssheets/fs279/en. Accessed 20 May 2016.

5. Kader Ç, Erbay A, Biringel S, Gürbüz M. Seroprevalance of hepatitis B virus, hepatitis C virus, human immunodeficiency virus infections and syphilis in blood donors. Klimik J 2010;23(3):95–9.

6. Uzun B, Güngör S, Demirci M. Seroprevalence of transfusion transmissible infections among blood donors in western part of Turkey: A six-year study. Transfusion and Apheresis Science 2013;49:511–5. doi: 10.1016/j.transci.2013.02.039 23491864

7. Glynn SA, Busch MP, Dodd RY, et al. Emerging infectious agents and nation’s blood supply: responding to potential threats in the 21st century. Transfusion 2013;53:438–54. doi: 10.1111/j.1537-2995.2012.03742.x 22690676

8. Güreser AS, Özçelik S, Boyacıoğlu Zİ, Özünel L, Yıldız Ü, Özkan AT. Seropositivity rates of HBsAg, anti-HCV, HIV and VDRL in blood donors in Corum, Turkey. Turk Hij Den Biyol Derg 2015; 72(2): 123–30.

9. Akcam FZ, Uskun E, Avsar K, Songur Y. Hepatitis B virus and hepatitis C virus sero prevalence in rural areas of the western region of Turkey. Int J Infect Dis 2009;13:274–84. doi: 10.1016/j.ijid.2008.07.005 18945630

10. World Health Organization (WHO). Global hepatitis report 2017 Geneva: World Health Organization. P.2017.

11. World Health Organization (WHO). Global Health Observatory (GHO) data HIV/AIDS. Available at http://www.who.int/gho/en./Accessed 11 April 2018.

12. World Health Organization [WHO]. Report on global sexually transmitted infection surveillance 2015. Geneva: World Health Orginization. P. 2015.

13. Temiz H, Gül K. The evaluation of HBsAg, anti-HIV and VDRL test results in blood donors. Turkish Journal of Infection 2008;22 [2]:79–82.

14. Noubiap JJN, Joko WYA, Nansseu JRN, Tene UG, Siaka C. Sero-epidemiology of human immunodeficiency virus, hepatitis B and C viruses, and syphilis among first-time blood donors in Edea, Cameroon. International Journal of Infectious Diseases 2013;17:e832–e837. doi: 10.1016/j.ijid.2012.12.007 23317526

15. Tagny CT, Owusu-Ofori S, Mbanya D, Deneys V. The blood donor in sub-Saharan Africa: a review. Transfus Med 2010;20:1–10.

16. Okoroiwu HU, Okafor IM, Asemota EA, Okpokam DC. Seroprevalence of transfusion-transmissible infections [HBV, HCV, syphilis and HIV] among prospective blood donors in a tertiary health care facility in Calabar, Nigeria; an eleven years evaluation. BMC Public Health 2018;18:645. doi: 10.1186/s12889-018-5555-x 29788937

17. Cao WW, Zhou RR, Ou X, Shi LX, Xiao CQ, Chen TY,et al. Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016. BMC Infectious Diseases 2018;18[1]:145. doi: 10.1186/s12879-018-3051-7 29606088

18. Sheikh MY, Atla PR, Ameer A, Sadiq H, Sadler PC. Seroprevalance of Hepatitis B and C infections among healthy volunteer blood donors in the Central California Valley. Gut and Liver 2013;7[1]:66–73. doi: 10.5009/gnl.2013.7.1.66 23423771

19. Chandekar SA, Amonkar GP, Desai HM, Valvi N, Puranik GV. Seroprevalance of transfusion transmitted infections in healthy blood donors: A 5-year tertiary care hospital experience. Journal of Laboratory Physicians 2017;9:4:283–87. doi: 10.4103/0974-2727.214246 28966492

20. Tessema B, Yismaw G, Kassu A, Amsalu A, Mulu A, Emmrich F, et al. Seroprevalance of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital Northwest Ethiopia: declining trends over a period of five years. BMC Infect Dis 2010;10:111–7. doi: 10.1186/1471-2334-10-111 20459703

21. Diarra A, Kouriba B, Baby M, Murphy E, Lefrere JJ. HIV, HBV, HCV and syphilis rate of positive donations among volunteer blood donors in Mali: lower rates among volunter blood donors. Transfus 2009:16(5–6):444–7.

22. Turan H, Şerefhanoğlu K, Ünler GK, Arslan H. Seroprevalance of HBsAg, anti-HCV and their correlation to age and gender in blood donors in the province of Konya. Klimik J 2011;24[1]:36–9.

23. Niazi SUK, Mahmood A, Alam M., Ghani E. Transfusion transmissible infections in blood donors from northern Pakistan: Three years experience (2010–2012). XIIth Annual conference of Asian association of transfusion medicine [AATM], 2–6 April 2016, Antalya/Turkey. Abstract book p368-369.

24. İçel O, Köroğlu M, Demiray T, Özbayraktar S, Akel N, Gün R,et al. Serotrends of the blood donor screening test results; Ten year review, Malatya. OTSBD 2016;1:3:1–7.

25. Umolu PI, Okoror LE, Orhue P. Human immunodeficiency virus (HIV) seropositivity and hepatitis B surface antigenemia (HBsAg) among blood donors in Benin city, Edo state. Nigeria Afr Health Sci 2005;5[1]:55–8. 15843132

26. Ağuş N, Özkalay YN, Cengiz A, Şanal E, Sert H. HBsAg, anti-HCV, anti-HIV seroprevalence in blood donors. Ankem J 2008;22(1):7–9.

27. Egglestone SI, Turner AJ. Serological diagnosis pf syphilis. PHLS syphilis serology working group. Commun Dis Public Health 2000;3:158–162. 11014025

28. Van der Bij AK, Coutinho RA, Van der Poel CL. Surveillance of risk profiles among new repeat blood donors with transfusion-transmissible infections from 1995 through 2003 in Netherlands. Transfusion 2006;46(10):1729–36. doi: 10.1111/j.1537-2995.2006.00964.x 17002629