Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
Autoři:
Jan-Willem M. Beenakker aff001; Joep Wezel aff001; Jan Groen aff003; Andrew G. Webb aff001; Peter Börnert aff001
Působiště autorů:
Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
aff001; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands
aff002; Philips Healthcare, Best, the Netherlands
aff003; Philips Research Laboratories, Hamburg, Germany
aff004
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0222573
Souhrn
Magnetic Resonance Imaging (MRI) has become a valuable imaging modality in ophthalmology, especially for the diagnosis and treatment planning of patients with uveal melanoma, the most common primary intra-ocular tumor. We aim to develop and evaluate the value of silent Zero Echo Time (ZTE) MRI to image patients with ocular tumors at 7Tesla. Therefore, ZTE and different types of magnetization-prepared ZTE (FLAIR, SPIR, T2 and Saturation recovery), have been developed. After an initial validation with 7 healthy subjects, nine patients with an eye tumor have been evaluated. The ZTE scans were compared to their Cartesian equivalent in terms of contrast, motion-sensitivity, diagnostic quality and patient comfort. All volunteers and especially the patients reported a more comfortable experience during the ZTE scans, which had at least a 10 dB lower sound pressure. The image contrast in the native ZTE was poor, but in the different magnetization-prepared ZTE, the eye lens, cornea and retina were clearly discriminated. Overall the T2-prepared scan yielded the best contrast, especially between tumor and healthy tissue, and proved to be robust against eye motion. Although the intrinsic 3D nature of the ZTE-technique provides an accurate analysis of the tumor morphology, the quality of the ZTE-images is lower than their Cartesian equivalent. In conclusion, the quality of magnetization-prepared ZTE images is sufficient to assess the 3D tumor morphology, but insufficient for more detailed evaluations. As such this technique can be an option for patients who cannot comply with the sound-levels of Cartesian scans, but for other patients the conventional Cartesian scans offer a better image quality.
Klíčová slova:
Biology and life sciences – Biochemistry – Physical sciences – Research and analysis methods – Anatomy – Medicine and health sciences – Diagnostic medicine – Lipids – Physics – Head – Fats – Imaging techniques – Diagnostic radiology – Magnetic resonance imaging – Radiology and imaging – Ophthalmology – Eyes – Ocular system – Ocular anatomy – Acoustics – Eye lens – Ocular tumors – Sound pressure – Echoes
Zdroje
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