Lung clearance index to detect the efficacy of Aztreonam lysine inhalation in patients with cystic fibrosis and near normal spirometry – A single-centre feasibility study
Autoři:
Helmut Ellemunter aff001; Gratiana Steinkamp aff001
Působiště autorů:
Cystic Fibrosis (CF) Centre at the Medical University of Innsbruck, Innsbruck, Austria
aff001; Clinical Research and Medical Scientific Writing, Schwerin, Germany
aff002
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0221673
Souhrn
Comparing the efficacy of inhaled antibiotics can be difficult in small groups of patients with cystic fibrosis and mild lung disease. In a feasibility study we compared Aztreonam lysine for inhalation solution (AZLI; Cayston®) to standard inhaled antibiotic therapy in patients with cystic fibrosis and near normal spirometry. To detect treatment responses we used both lung clearance index (LCI) and forced expiratory volume in one second (FEV1). At baseline, median FEV1 was 87% pred. and median LCI was 8.6 (upper limit of normal: 7.0). After 4 weeks, LCI improved by -0.36 after AZLI and deteriorated by +0.12 after tobramycin treatment (p = 0.039). No significant differences between treatments (p = 0.195) were observed using FEV1. These results suggest that lung clearance index can be used to detect treatment induced changes in subjects with mild lung disease.
Klíčová slova:
Biology and life sciences – Biochemistry – Organisms – Physical sciences – Chemistry – Research and analysis methods – Proteins – Developmental biology – Medicine and health sciences – Chemical compounds – Microbiology – Medical microbiology – Microbial pathogens – Bacterial pathogens – Pseudomonas aeruginosa – Bacteria – Pseudomonas – Pathology and laboratory medicine – Pathogens – Physiology – Amino acids – Organic compounds – Organic chemistry – Pharmacology – Physiological processes – Pulmonology – Respiratory infections – Microbial control – Antimicrobials – Antibiotics – Drugs – Fibrosis – Bioassays and physiological analysis – Clinical genetics – Genetic diseases – Autosomal recessive diseases – Cystic fibrosis – Respiration – Inhalation – Respiratory physiology – Basic amino acids – Lysine – Respiratory analysis – Spirometry
Zdroje
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