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Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study


Autoři: Shoko Tamaki aff001;  Akio Kanazawa aff001;  Junko Sato aff001;  Yoshifumi Tamura aff001;  Takashi Asahara aff003;  Takuya Takahashi aff003;  Satoshi Matsumoto aff003;  Yuichiro Yamashiro aff003;  Hirotaka Watada aff001
Působiště autorů: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan aff001;  Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan aff002;  Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan aff003;  Yakult Central Institute, Tokyo, Japan aff004;  Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan aff005;  Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan aff006
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222598

Souhrn

Objective

To explore clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes mellitus (T2DM).

Methods

The data of 118 patients with T2DM were obtained from two previous clinical studies, and were retrospectively analyzed regarding the clinical parameters associated with bacterial translocation defined as detection of bacteremia and levels of plasma lipopolysaccharide binding protein (LBP), the latter of which is thought to reflect inflammation caused by endotoxemia.

Results

LBP level was not significantly different between patients with and without bacteremia. No clinical factors were significantly correlated with the detection of bacteremia. On the other hand, plasma LBP level was significantly correlated with HbA1c (r = 0.312), fasting blood glucose (r = 0.279), fasting C-peptide (r = 0.265), body mass index (r = 0.371), high-density lipoprotein cholesterol (r = -0.241), and inflammatory markers (high-sensitivity C-reactive protein, r = 0.543; and interleukin-6, r = 0.456). Multiple regression analysis identified body mass index, HbA1c, high-sensitivity C-reactive protein, and interleukin-6 as independent determinants of plasma LBP level.

Conclusion

The plasma LBP level was similar in patients with and without bacteremia. While both bacteremia and LBP are theoretically associated with bacterial translocation, the detection of bacteremia was not associated with LBP level in T2DM.

Klíčová slova:

Biology and life sciences – Biochemistry – Physical sciences – Research and analysis methods – Proteins – Mathematics – Anatomy – Medicine and health sciences – Pathology and laboratory medicine – Physiology – Diagnostic medicine – Signs and symptoms – Endocrinology – Endocrine disorders – Metabolic disorders – Infectious diseases – Bacterial diseases – Statistics – Mathematical and statistical techniques – Statistical methods – Immunology – Immune response – Inflammation – Diabetes diagnosis and management – HbA1c – Hemoglobin – Body fluids – Blood – Blood plasma – Regression analysis – Blood sugar – Bacteremia


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