The role of C-reactive protein levels on the association of physical activity with lung function in adults

English version

Autoři: Elaine Fuertes ^aff001; Anne-Elie Carsin ^aff001; Vanessa Garcia-Larsen ^aff005; Stefano Guerra ^aff001; Isabelle Pin ^aff007; Bénédicte Leynaert ^aff010; Simone Accordini ^aff012; Jesús Martinez-Moratalla ^aff013; Josep M. Antó ^aff001; Isabel Urrutia ^aff015; Audrey Le Gouellec ^aff016; Joachim Heinrich ^aff017; Thorarinn Gislason ^aff019; Rain Jõgi ^aff020; Christer Janson ^aff021; Debbie Jarvis ^aff004; Judith Garcia-Aymerich ^aff001
Působiště autorů: ISGlobal, Barcelona, Spain ^aff001; Universitat Pompeu Fabra (UPF), Barcelona, Spain ^aff002; CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain ^aff003; National Heart and Lung Institute, Imperial College London, London, United Kingdom ^aff004; Program in Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America ^aff005; Asthma and Airway Disease Research Center, University of Arizona - Tucson, Arizona, United States of America ^aff006; Department of Pediatrics, CHU Grenoble Alpes, Grenoble, France ^aff007; INSERM, Institut for Advanced Biosciences, Grenoble, France ^aff008; University Grenoble Alpes, Grenoble, France ^aff009; UMR 1152, Pathophysiology and Epidemiology of Respiratory Diseases, INSERM, Paris, France ^aff010; UMR 1152, University Paris Diderot Paris, Paris, France ^aff011; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy ^aff012; Servicio de Neumologia del Complejo, Servicio de Salud de Castilla – La Mancha (SESCAM), Hospitalario Universitario de Albacete, Albacete, Spain ^aff013; Facultad de Medicina de Albacete, Universidad de Castilla - La Mancha, Albacete, Spain ^aff014; Department of Respiratory, Galdakao Hospital, Galdakao, Spain ^aff015; University Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC-IMAG, Grenoble, France ^aff016; Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Munich, Germany ^aff017; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital Munich, Ludwig Maximilians University Munich, Munich, Germany ^aff018; Department of Respiratory Medicine and Sleep, Landspitali University Hospital Reykjavik, Reykjavik, Iceland ^aff019; Lung Clinic, Tartu University Hospital, Tartu, Estonia ^aff020; Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden ^aff021; MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom ^aff022
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222578

Souhrn

Objective

Regular physical activity may be associated with improved lung function via reduced systemic inflammation, although studies exploring this mechanism are rare. We evaluated the role of C-reactive protein in blood, which is a common marker of systemic inflammation, on the association of physical activity with forced expiratory volume in one second and forced vital capacity.

Methods

Cross-sectional data on spirometry, C-reactive protein levels and self-reported physical activity (yes/no; ≥2 times and ≥1hr per week of vigorous physical activity) were available in the European Community Respiratory Health Survey (N = 2347 adults, 49.3% male, 28–56 years-old). A subsample was also assessed 10 years later using the International Physical Activity Questionnaire, and tertiles of Metabolic Equivalent of Task—minutes per week spent in vigorous, moderate and walking activities were calculated (N = 671, 49.6% male, 40–67 years-old). Adjusted cross-sectional mixed linear regression models and the “mediate” package in “R” were used to assess the presence of mediation.

Results

Despite positive significant associations between nearly all physical activity metrics with forced expiratory volume in one second and forced vital capacity, there was no evidence that C-reactive protein levels played a role. An influence of C-reactive protein levels was only apparent in the smaller subsample when comparing the medium to low tertiles of moderate activity (mean difference [95% CIs]: 21.1ml [5.2, 41.9] for forced expiratory volume in one second and 17.3ml [2.6, 38.0] for forced vital capacity).

Conclusions

In a population of adults, we found no consistent evidence that the association of physical activity with forced expiratory volume in one second or forced vital capacity is influenced by the level of C-reactive protein in blood.

Klíčová slova:

Professions – Inflammation – Physical activity – Pulmonary function – Smoking habits – Questionnaires – C-reactive proteins – Health surveys

Zdroje

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