Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
Autoři:
Yves Lula Ntamba aff001; Hypolite Muhindo Mavoko aff002; Marion Kalabuanga aff004; Blaise Fungula aff004; Pierre-Michel Ntamabyaliro Nsengi aff001; Gaston Tona Lutete aff001; Raquel Inocencio da Luz aff002; Jean-Pierre Van geertruyden aff002; Pascal Lutumba aff003
Působiště autorů:
Clinical Pharmacology and Pharmacovigilance Unit, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
aff001; Global Health Institute, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
aff002; Department of Tropical Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
aff003; Lisungi Health Centre, Kinshasa, Democratic Republic of the Congo
aff004
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0222379
Souhrn
Introduction
Artemisinin-based combination therapy is currently the best option for the treatment of uncomplicated malaria. Quinine is recommended as a rescue treatment. Safety information during repeated treatment with the same drug is scarce. We report safety data from the Quinact randomized clinical trial (RCT) that was designed to assess efficacy and safety of artesunate-amodiaquine (ASAQ), artemether-lumefantrine (AL) and quinine+clindamycin (QnC).
Methodology
Males and females aged 12 to 59 months with uncomplicated malaria were treated with ASAQ and followed up during 42 days (preRCT). Clinical failures were randomized to one of the 3 treatments and followed up for 28 days (RCT). Subsequent failures were repeatedly treated with ASAQ several times as needed (postRCT1, postRCT2 and so on) until a 28-days follow up period without parasitaemia.
Results
Eight hundred and sixty-five, 242 and 64 patients were recruited respectively in preRCT, RCT and postRCTs. In preRCT, 433 (50.0%) patients experienced at least one drug-related adverse event (AE). The most reported AEs were anorexia (22.9%), asthenia (19.4%), and abnormal behavior (14.6%). Twenty-nine AEs (3.5%) were reported to be severe. In RCT, at least one drug-related AE was reported in 54.7%, 21.5% and 40.0% of patient randomized respectively to ASAQ, AL and QnC (p<0.001). During postRCT1 (n = 64), postRCT 2 (n = 17) and postRCT3 (n = 7), respectively 32.8%, 35.3% and 71.4% of patients experienced at least one drug-related AE. Three serious adverse events occurred but not judged related to study medication.
Conclusion
The proportion of AEs did not increase over the treatment courses with ASAQ. However, continuous monitoring is important.
Klíčová slova:
anémia – Biology and life sciences – Research and analysis methods – Medicine and health sciences – Pathology and laboratory medicine – Physiology – Diagnostic medicine – Signs and symptoms – Pharmacology – Tropical diseases – Research design – Clinical medicine – Physiological processes – Clinical trials – Drug research and development – Hematology – Drugs – Parasitic diseases – Clinical research design – Adverse events – Mental health and psychiatry – Malaria – Coughing – Antimalarials – Amodiaquine – Randomized controlled trials – Eating disorders – Anorexia nervosa
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