Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation
Autoři:
Jose M. Guerrero aff001; Nagesh Adluru aff002; Barbara B. Bendlin aff003; H. Hill Goldsmith aff002; Stacey M. Schaefer aff005; Richard J. Davidson aff005; Steven R. Kecskemeti aff002; Hui Zhang aff006; Andrew L. Alexander aff001
Působiště autorů:
Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, United States of America
aff001; Waisman Center, University of Wisconsin - Madison, Madison, WI, United States of America
aff002; Department of Medicine, University of Wisconsin - Madison, Madison, WI, United States of America
aff003; Department of Psychology, University of Wisconsin - Madison, Madison, WI, United States of America
aff004; Center for Healthy Minds, University of Wisconsin - Madison, Madison, WI, United States of America
aff005; Department of Computer Science, University College London, London, United Kingdom
aff006
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0217118
Souhrn
Purpose
NODDI is widely used in parameterizing microstructural brain properties. The model includes three signal compartments: intracellular, extracellular, and free water. The neurite compartment intrinsic parallel diffusivity (d∥) is set to 1.7 μm2⋅ms−1, though the effects of this assumption have not been extensively explored. This work investigates the optimality of d∥ = 1.7 μm2⋅ms−1 under varying imaging protocol, age groups, sex, and tissue type in comparison to other biologically plausible values of d∥.
Methods
Model residuals were used as the optimality criterion. The model residuals were evaluated in function of d∥ over the range from 0.5 to 3.0 μm2⋅ms−1. This was done with respect to tissue type (i.e., white matter versus gray matter), sex, age (infancy to late adulthood), and diffusion-weighting protocol (maximum b-value). Variation in the estimated parameters with respect to d∥ was also explored.
Results
Results show d∥ = 1.7 μm2⋅ms−1 is appropriate for adult brain white matter but it is suboptimal for gray matter with optimal values being significantly lower. d∥ = 1.7 μm2⋅ms−1 was also suboptimal in the infant brain for both white and gray matter with optimal values being significantly lower. Minor optimum d∥ differences were observed versus diffusion protocol. No significant sex effects were observed. Additionally, changes in d∥ resulted in significant changes to the estimated NODDI parameters.
Conclusion
The default (d∥) of 1.7 μm2⋅ms−1 is suboptimal in gray matter and infant brains.
Klíčová slova:
Neonates – Age groups – Diffusion tensor imaging – Neuroimaging – Central nervous system – Data acquisition – Neurites – Diffusion magnetic resonance imaging
Zdroje
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