The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers

English version

Autoři: Kristian Magnus Gundersen ^aff001; Christoffer Nyborg ^aff001; Øyvind Heiberg Sundby ^aff001; Jonny Hisdal ^aff001
Působiště autorů: Section of Vascular Investigations, Department of Vascular Surgery, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital, Oslo, Norway ^aff001; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway ^aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0219814

Souhrn

Objective

To investigate the association between sympathetic activity, reactive hyperemia and brachial artery flow-mediated dilation (FMD).

Background

It is claimed that major surgery has an impact on endothelial function, as observed by post-operative reduced brachial artery FMD response. However, another explanation for the observed reduced FMD response post-operatively may be sympathetic stress-induced reduction in blood flow.

Methods

Seventeen healthy volunteers with a median age (25^th-75^th percentiles) of 23.5 (23–24.8) years were recruited. Participants’ brachial blood flow and FMD response were measured (i) during normal non-stress conditions (Normal₁); (ii) during exposure to ice water; and (iii) afterwards, under normal non-stress conditions (Normal₂). We continuously measured arterial blood pressure (Finometer), heart rate (ECG), skin blood flow of the index finger (laser Doppler), and brachial artery blood flow and diameter (Ultrasound Doppler). Measurements were taken at baseline; before a 5-min suprasystolic forearm occlusion; and following a 3-min post-occlusion, to measure reactive hyperemia and FMD.

Results

Median (25^th-75^th percentiles) FMD response after exposure to ice water was reduced compared to non-stress conditions [4.9 (2.9–8.4) % during ice water vs. 9.7 (7.6–12.2) % Normal₁ and 9.7 (6.4–10.3) % Normal₂, P < 0.001]. Blood flow 60 s after cuff-deflation during ice water exposure was significantly reduced to 328 (289–421) mL compared to non-stress conditions (both P < 0.05). No differences were observed between Normal₁ [446 (359–506) mL] and Normal₂ [455 (365–515) mL] (both P > 0.05). Heart rate significantly increased during ice water exposure [67 (59–69) beats/min)] compared to 55 (49–60) beats/min during Normal₁ and 54 (47–60) beats/min during Normal₂ (both P < 0.05). MAP did not change during Normal₁ [72 (64–84)] or during Normal₂ [71 (65–81) mm Hg] (both P > 0.05), but increased to 86 (75–98) mm Hg during ice water exposure (P < 0.05).

Conclusions

Increased sympathetic activity resulted in decreased blood flow and brachial artery FMD response in healthy volunteers, independent of endothelial dysfunction. Future studies should adjust for blood flow when interpreting the FMD response.

Klíčová slova:

Biology and life sciences – Physical sciences – Anatomy – Medicine and health sciences – Physiology – Body fluids – Blood – Public and occupational health – Physical activity – Physics – Vascular medicine – Classical mechanics – Cardiology – Surgical and invasive medical procedures – Cardiovascular anatomy – Cardiovascular procedures – Blood pressure – Blood vessels – Arteries – Blood flow – Mechanical stress – Vascular surgery – Heart rate – Shear stresses

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