Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction

English version

Autoři: Rafael Aguiar Marschner ^aff001; Patrícia Banda ^aff001; Simone Magagnin Wajner ^aff002; Melissa Medeiros Markoski ^aff003; Maximiliano Schaun ^aff001; Alexandre Machado Lehnen ^aff001
Působiště autorů: Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology, Porto Alegre, Rio Grande do Sul, Brazil ^aff001; Thyroid Division, Endocrinology Service, Hospital de Clínicas de Porto Alegre/Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil ^aff002; Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil ^aff003
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222334

Souhrn

Aims

We assessed the effects of a short-term exercise training on cardiac function, oxidative stress markers, and type 3 iodothyronine deiodinase (D3) activity in cardiac tissue of spontaneously hypertensive rats (SHR) following experimental myocardial infarction (MI).

Methods

Twenty-four SHR (aged 3 months) were allocated to 4 groups: sham+sedentary, sham+trained, MI+sedentary and MI+trained. MI was performed by permanent ligation of the coronary artery. Exercise training (treadmill) started 96 hours after MI and lasted for 4 weeks (~60% maximum effort, 4x/week and 40 min/day). Cardiac function (echocardiography), thioredoxin reductase (TRx), total carbonyl levels, among other oxidative stress markers and D3 activity were measured. A Generalized Estimating Equation was used, followed by Bonferroni’s test (p<0.05).

Results

MI resulted in an increase in left ventricular mass (p = 0.002) with decreased cardiac output (~22.0%, p = 0.047) and decreased ejection fraction (~41%, p = 0.008) as well as an increase in the carbonyl levels (p = 0.001) and D3 activity (~33%, p<0.001). Exercise training resulted in a decrease in left ventricular mass, restored cardiac output (~34%, p = 0.048) and ejection fraction (~20%, p = 0.040), increased TRx (~85%, p = 0.007) and reduced carbonyl levels (p<0.001) and D3 activity (p<0.001).

Conclusions

Our short-term exercise training helped reverse the effects of MI on cardiac function. These benefits seem to derive from a more efficient antioxidant response and lower D3 activity in cardiac tissue.

Klíčová slova:

Biology and life sciences – Cell biology – Biochemistry – Physical sciences – Chemistry – Chemical reactions – Medicine and health sciences – Physiology – Public and occupational health – Physical activity – Cardiology – Sports science – Sports and exercise medicine – Exercise – Physical fitness – Antioxidants – Oxidative stress – Electrochemistry – Myocardial infarction – Cardiac output – Cardiovascular physiology – Peptides – Glutathione – Oxidation-reduction reactions

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