Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status

English version

Autoři: Hyun-Jung Lee ^aff001; Hack-Lyoung Kim ^aff001; Woo-Hyun Lim ^aff001; Jae-Bin Seo ^aff001; Sang-Hyun Kim ^aff001; Joo-Hee Zo ^aff001; Myung-A. Kim ^aff001
Působiště autorů: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Boramae Medical Center, Seoul, Korea ^aff001
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222118

Souhrn

Background

Obesity and metabolic syndrome (MetS) are associated with high risk of cardiac dysfunction and heart failure. We assessed the effect of obesity and metabolic health status on left ventricular (LV) structure and function in subjects without overt heart disease.

Methods

In 789 subjects (58.8±13.0 years, 50.7% males) without overt heart disease, LV morphology and function were compared among 6 groups stratified by body mass index (BMI) (normal weight, overweight and obese) and metabolic health status (meeting ≤1 criterion of MetS excluding waist circumference defined as metabolically healthy; otherwise, metabolically unhealthy).

Results

LV ejection fraction (LVEF) was not different among the 6 groups (P>0.05). However, high BMI and poor metabolic health were associated with poorer global longitudinal strain (GLS), higher LV mass index (LVMI) and higher E/e′ (P<0.001). Poor metabolic health status was associated with greater adverse changes in LV structure and function than obesity, and among MetS components, high systolic blood pressure (SBP) showed the greatest impact. Higher SBP, BMI and triglycerides were independently associated with worse GLS, and higher SBP was also associated with worse LVMI and E/e´. GLS, LVMI and E/e´ worsened in proportion to the number of MetS criteria or continuous MetS scores. Adverse myocardial changes associated with obesity were significant in the metabolically healthy group, but not in the metabolically unhealthy group.

Conclusions

Obesity and poor metabolic health status were associated with subclinical decrement in LV systolic and diastolic function, and higher LV mass, but not with LVEF, in subjects without overt heart disease.

Klíčová slova:

Body Mass Index – Biology and life sciences – Biochemistry – Research and analysis methods – Medicine and health sciences – Physiology – Physiological parameters – Diagnostic medicine – Pharmacology – Body weight – Pharmacokinetics – Drug metabolism – Lipids – Metabolism – Carbohydrate metabolism – Glucose metabolism – Cholesterol – Vascular medicine – Imaging techniques – Obesity – Diagnostic radiology – Radiology and imaging – Cardiovascular medicine – Blood pressure – Ultrasound imaging – Echocardiography – Cardiovascular diseases

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