#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis


Autoři: Zhaowei Zhu aff001;  Jia Zhao aff002;  Yinghui Li aff003;  Chen Pang aff004;  Zhanwei Zhu aff005;  Xuepei Zhang aff001
Působiště autorů: Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China aff001;  Center for Geriatrics, Yidu Central Hospital of Weifang, Qingzhou, Shandong, PR China aff002;  Department of Urology, People’s Hospital of Gongyi City, Zhengzhou, Henan, PR China aff003;  Department of Urology, Nanshi Hospital of Nanyang, Nanyang, Henan, PR China aff004;  Department of Urology, People’s Hospital of Huaxian, Huaxian, Henan, PR China aff005
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222223

Souhrn

Background

Hydronephrosis is a common finding in patients with bladder cancer. The aim of the study was to appraise the prognostic value of preoperative hydronephrosis in bladder cancer patients undergoing radical cystectomy.

Methods

We conducted a literature search using PubMed and Embase databases in Aug 2018. Summary hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using fixed-effect or random-effects models. The primary endpoint was overall survival (OS). Secondary endpoints were cancer-specific survival (CSS) and recurrence-free survival (RFS).

Results

Overall, 13 studies published between 2008 and 2018 including 4,820 patients were selected for the meta-analysis. The age of bladder cancer patients ranged from 27 to 90.4 years, and the overall proportion of males was 72.5%. Preoperative hydronephrosis was reported in 27.4% of patients. The pooled HR was statistically significant for OS (HR, 1.36; 95% CI [1.20–1.55]) and CSS (HR, 1.64; 95% CI [1.33–2.02]), with no heterogeneity among the enrolled studies. Patients with bilateral hydronephrosis showed a poorer CSS compared to those with no hydronephrosis (HR 5.43, 95% CI [3.14–9.40]). However, there was no difference in CSS between no hydronephrosis and unilateral hydronephrosis groups (HR 1.35, 95% CI [0.84–2.14]). Despite a tendency towards poorer RFS (HR, 1.27; 95% CI [0.96–1.96]), the results demonstrated no significant association between presence of preoperative hydronephrosis and RFS after radical cystectomy.

Conclusion

This meta-analysis indicates that preoperative hydronephrosis is significantly associated with poorer OS and CSS after radical cystectomy for patients with bladder cancer. Preoperative hydronephrosis has a stronger effect on CSS in patients with bilateral hydronephrosis. The presence of preoperative hydronephrosis not only predicts prognosis, but may also help to identify patients who benefit the most from neoadjuvant chemotherapy.

Klíčová slova:

Physical sciences – Research and analysis methods – Database and informatics methods – People and places – Mathematics – Geographical locations – Medicine and health sciences – Diagnostic medicine – Statistics – Mathematical and statistical techniques – Statistical methods – Metaanalysis – Urology – Oncology – Cancer treatment – Cancers and neoplasms – Surgical and invasive medical procedures – Database searching – Science policy – North America – United States – Urinary system procedures – Prognosis – Research integrity – Publication ethics – Genitourinary tract tumors – Bladder cancer – Surgical excision – Cystectomy


Zdroje

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7–30. doi: 10.3322/caac.21442 29313949

2. Shariat SF, Karakiewicz PI, Palapattu GS, Lotan Y, Rogers CG, Amiel GE, et al. Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium. J Urol. 2006;176:2414–22; discussion 2422. doi: 10.1016/j.juro.2006.08.004 17085118

3. Collaboration ABC(M. Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration. Eur Urol. 2005;48:202–5; discussion 205–6. doi: 10.1016/j.eururo.2005.04.006 15939524

4. Grossman HB, Natale RB, Tangen CM, Speights VO, Vogelzang NJ, Trump DL, et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med. 2003;349:859–66. doi: 10.1056/NEJMoa022148 12944571

5. Bartsch GC, Kuefer R, Gschwend JE, de Petriconi R, Hautmann RE, Volkmer BG. Hydronephrosis as a prognostic marker in bladder cancer in a cystectomy-only series. Eur Urol. 2007;51:690–7; discussion 697–8. doi: 10.1016/j.eururo.2006.07.009 16904815

6. Canter D, Guzzo TJ, Resnick MJ, Brucker B, Vira M, Chen Z, et al. Hydronephrosis is an independent predictor of poor clinical outcome in patients treated for muscle-invasive transitional cell carcinoma with radical cystectomy. Urology. 2008;72:379–83. doi: 10.1016/j.urology.2008.03.053 18514771

7. Chapman DM, Pohar KS, Gong MC, Bahnson RR. Preoperative hydronephrosis as an indicator of survival after radical cystectomy. Urol Oncol. 2009;27:491–5. doi: 10.1016/j.urolonc.2008.06.001 18657452

8. Resorlu B, Baltaci S, Resorlu M, Ergun G, Abdulmajeed M, Haliloglu AH, et al. Prognostic significance of hydronephrosis in bladder cancer treated by radical cystectomy. Urol Int. 2009;83:285–8. doi: 10.1159/000241668 19829026

9. Kim DS, Cho KS, Lee YH, Cho NH, Oh YT, Hong SJ. High-grade hydronephrosis predicts poor outcomes after radical cystectomy in patients with bladder cancer. J Korean Med Sci. 2010;25:369–73. doi: 10.3346/jkms.2010.25.3.369 20191034

10. Stimson CJ, Cookson MS, Barocas DA, Clark PE, Humphrey JE, Patel SG, et al. Preoperative hydronephrosis predicts extravesical and node positive disease in patients undergoing cystectomy for bladder cancer. J Urol. 2010;183:1732–7. doi: 10.1016/j.juro.2010.01.028 20299043

11. Asadauskiene J, Aleknavicius E, Pipiriene-Zelviene T, Jankevicius F. The value of clinical prognostic factors for survival in patients with invasive urinary bladder cancer. Medicina (Kaunas). 2010;46:305–14.

12. Hofner T, Haferkamp A, Knapp L, Pahernik S, Hadaschik B, Djakovic N, et al. Preoperative hydronephrosis predicts advanced bladder cancer but is not an independent factor for cancer-specific survival after radical cystectomy. Urol Int. 2011;86:25–30. doi: 10.1159/000321008 21042001

13. Lin HY, Wang SZ, Chen JX, Chen LW, Xiao J. The prognostic value of hydronephrosis in bladder cancer treated by radical cystectomy. Urologia. 2011;78:17–21. 21452155

14. Gondo T, Nakashima J, Ohno Y, Choichiro O, Horiguchi Y, Namiki K, et al. Prognostic value of neutrophil-to-lymphocyte ratio and establishment of novel preoperative risk stratification model in bladder cancer patients treated with radical cystectomy. Urology. 2012;79:1085–91. doi: 10.1016/j.urology.2011.11.070 22446338

15. Mitra AP, Skinner EC, Schuckman AK, Quinn DI, Dorff TB, Daneshmand S. Effect of gender on outcomes following radical cystectomy for urothelial carcinoma of the bladder: a critical analysis of 1,994 patients. Urol Oncol. 2014;32:52.e1–9.

16. Hirasawa Y, Nakashima J, Yunaiyama D, Sugihara T, Gondo T, Nakagami Y, et al. Sarcopenia as a Novel Preoperative Prognostic Predictor for Survival in Patients with Bladder Cancer Undergoing Radical Cystectomy. Ann Surg Oncol. 2016;23:1048–54. doi: 10.1245/s10434-016-5606-4 27699608

17. Soria F, Moschini M, Haitel A, Wirth GJ, Gust KM, Briganti A, et al. The effect of HER2 status on oncological outcomes of patients with invasive bladder cancer. Urologic Oncology: Seminars and Original InvestigationsUrol. Oncol. Semin. Orig. Invest. 2016;34:533.e1–533.e10.

18. Vasdev N, Zargar H, Noël JP, Veeratterapillay R, Fairey AS, Mertens LS, et al. Concomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomy. World J Urol. 2018.

19. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. doi: 10.1136/bmj.b2535 19622551

20. Zhu Z, Zhang X, Shen Z, Zhong S, Wang X, Lu Y, et al. Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies. PLoS One. 2013;8:e56662. doi: 10.1371/journal.pone.0056662 23437204

21. Zhu Z, Wang X, Shen Z, Lu Y, Zhong S, Xu C. Risk of bladder cancer in patients with diabetes mellitus: an updated meta-analysis of 36 observational studies. BMC Cancer. 2013;13:310. doi: 10.1186/1471-2407-13-310 23803148

22. Harris R, Bradburn M, Deeks J, Harbord R, Altman D, Sterne J (2008) metan: fixed- and random-effects meta-analysis. Stata Journal 8: 3.

23. Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34. doi: 10.1136/bmj.315.7109.629 9310563

24. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101. 7786990

25. Altman DG, Bland JM. How to obtain the confidence interval from a P value. BMJ. 2011;343:d2090. doi: 10.1136/bmj.d2090 21824904

26. Seisen T, Granger B, Colin P, Léon P, Utard G, et al. (2015) A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma. Eur Urol 67: 1122–1133. doi: 10.1016/j.eururo.2014.11.035 25488681

27. Mari A, Kimura S, Foerster B, Abufaraj M, D'Andrea D, Gust KM, et al. A systematic review and meta-analysis of lymphovascular invasion in patients treated with radical cystectomy for bladder cancer. Urol Oncol. 2018;36:293–305. doi: 10.1016/j.urolonc.2018.03.018 29685374

28. Tian Y, Gong Y, Pang Y, Wang Z, Hong M (2016) Clinical and prognostic value of preoperative hydronephrosis in upper tract urothelial carcinoma: a systematic review and meta-analysis. PeerJ 4: e2144. doi: 10.7717/peerj.2144 27366646

29. Mitra A.P., Skinner E.C., Miranda G., and Daneshmand S. 2013. A precystectomy decision model to predict pathological upstaging and oncological outcomes in clinical stage T2 bladder cancer. BJU Int. 111: 240–248. doi: 10.1111/j.1464-410X.2012.11424.x 22928881

30. CJD W., Klaassen Z., Bhindi B., Ye X.Y., Chandrasekar T., Farrell A.M., et al. 2018. First-line Systemic Therapy for Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis. Eur Urol. 74: 309–321. doi: 10.1016/j.eururo.2018.03.036 29656851


Článok vyšiel v časopise

PLOS One


2019 Číslo 9
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#