Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
Authors:
Alexandra Lenhard aff001; Wolfgang Lenhard aff002; Sebastian Gary aff002
Authors place of work:
Test Development Center, Psychometrica, Dettelbach, Bavaria, Germany
aff001; Institute of Psychology, University of Wuerzburg, Bavaria, Germany
aff002
Published in the journal:
PLoS ONE 14(9)
Category:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0222279
Summary
Continuous norming methods have seldom been subjected to scientific review. In this simulation study, we compared parametric with semi-parametric continuous norming methods in psychometric tests by constructing a fictitious population model within which a latent ability increases with age across seven age groups. We drew samples of different sizes (n = 50, 75, 100, 150, 250, 500 and 1,000 per age group) and simulated the results of an easy, medium, and difficult test scale based on Item Response Theory (IRT). We subjected the resulting data to different continuous norming methods and compared the data fit under the different test conditions with a representative cross-validation dataset of n = 10,000 per age group. The most significant differences were found in suboptimal (i.e., too easy or too difficult) test scales and in ability levels that were far from the population mean. We discuss the results with regard to the selection of the appropriate modeling techniques in psychometric test construction, the required sample sizes, and the requirement to report appropriate quantitative and qualitative test quality criteria for continuous norming methods in test manuals.
Keywords:
Biology and life sciences – Physical sciences – Research and analysis methods – Psychology – Social sciences – People and places – Population groupings – Mathematics – Probability theory – Simulation and modeling – statistics – Age groups – Probability distribution – Skewness – Normal distribution – Algebra – Polynomials – Psychometrics – Statistical distributions – Statistical models
Introduction
Precise and reliable norm scores are an important quality criterion for psychometric tests, because critical life decisions, such as school placement decisions, rehabilitative treatment, and psychotherapeutic intervention decisions, are often based on the results of psychometric tests. In many countries, supportive measures for children with intellectual disabilities are almost exclusively restricted to children with a general IQ below 70. The granting of support measures, therapy, or compensation for specific learning disorders at school also regularly depends on whether a normed score of an appropriate test of reading, writing, or mathematics falls below a certain threshold [1]. Furthermore, strict cutoffs play a vital role in epidemiologic studies (e.g., in the seminal Isle of Wight studies [2]). Even in court decisions, an IQ score of 70 is used as a threshold to assess the accountability of a defendant. Given the importance of such decisions, a psychometric test should not only possess sufficient reliability and validity of the obtained raw scores, but it should also be able to precisely rank the raw scores in relation to the reference sample.
Conventional and continuous norming
Whenever there are precise criteria on how raw scores can directly be interpreted, as is the case with criterion or mastery-referenced tests, there is no need to convert these raw scores into norm scores. For example, a criterion-referenced reading test could require a child to read aloud a text within a certain time and without exceeding a defined number of errors. However, the vast majority of psychometric tests aim to classify a test result in relation to a reference population. Within this scope, raw scores of a certain test can only be interpreted meaningfully, if population-based comparative scores–i.e., norm scores—are available [3]. Norm Scores indicate how the raw scores of a test are distributed in the population, that is, they are an estimator for the probability of a specific test result in the population. To produce the norm tables, the empirical cumulative distribution function of the raw scores must be determined on the basis of a sufficiently large and representative sample, which specifies this probability. The latter can, for example, be expressed in the form of percentiles. However, since percentiles do not represent a linear transformation of the raw scores, further computation with percentiles may lead to bias. Therefore, the percentiles are usually transformed into norm scores like, for example, IQ-scores or z-scores via normal rank transformation (i.e., by use of the inverse normal distribution function) and reported as such. The norming of psychometric tests can thus be defined as setting up population-based reference scores in order to be able to assess the exceptionality of an individual test result.
Many psychometric tests are based on the assumption that the raw scores are a manifest expression of a latent personality trait or ability which itself cannot be directly assessed. As highlighted in Fig 1, norming aims at mapping the raw scores of a test to that latent ability. While the latter one is usually assumed to be normally distributed, the same unfortunately does not apply to the raw score distribution. For example, most test scales have only a limited range of discrete possible outcomes, which can lead to skewed distributions constrained with floor or ceiling effects. The fact that abilities normally develop over the life span makes this process even more complicated. In intelligence tests, for example, the raw scores, which are supposed to reflect the level of the latent ability, increase swiftly with age. Therefore, a child has to be compared to a sample of children with the same or similar age in order to be able to assess the exceptionality of the individual test result. Consequently, in tests covering a wide age range, the normative samples have to be split up into multiple subsamples with a sufficiently narrow age range. This requirement quickly results in a large total sample size and can in addition lead to imbalances between the subsamples. At this point, continuous norming methods come into play. Their aim is to continuously model the change of the raw score distributions across age (as for example shown by the dashed lines in Fig 1C). Thus, norm scores can be specified for very narrow age brackets or even for specific age levels or schooling durations. Continuous norming can theoretically solve a whole series of problems of conventional norming: First, it reduces errors that occur due to random sampling. Second, it eliminates bias that occurs because a child's age does not correspond to the average age of the respective age group within the normative sample. Third, the norm tables do not contain the usual gaps of conventionally generated norm tables. Finally, continuous norming also requires smaller sample sizes than conventional norming and thus makes the norming procedures more cost-efficient [3–5].
Norming as the group-specific (e.g., age-specific) mapping of raw scores to latent abilities.
While the latent trait or ability is normally distributed in every single age group, the features and shapes of the resulting raw score distributions can change depending on age. As the norm scores are scaled with respect to each separate age-group, they reflect the exceptionality of the test result within a certain age group but do not reflect general developmental changes of the latent ability between age groups.
There are several mathematical approaches, which can principally be used for continuous norming. They differ in at least three aspects, (1) the assumptions about the distribution of the raw scores of a test scale, (2) the optimization procedures implemented to increase the goodness of fit, and finally (3) the operationalization of independent variables and dependent measures.
A first way to create continuous norms consists in modeling the age progressions for each percentile individually, that is, the raw scores serve as the dependent variables, which are modeled as a function of age, while the percentile (i.e., the level of the latent trait or ability) is kept constant. This approach is also known as quantile regression [6,7]. It makes no specific assumptions about the raw score distributions and can therefore–in accordance with statistic convention–be classified as nonparametric. However, quantile regression is accompanied by some major disadvantages. First, individual percentile curves may intersect, which would violate the assumption that the assignment of raw scores to norm scores at a fixed age level must be monotonic. Second, as each percentile is modeled individually, the method is rather cumbersome and inefficient to apply within psychometrics. And third, error minimization or probability maximization of an overall model is not possible within this approach as there is no joint estimation or linkage between the individual percentiles. These reasons may have contributed to the fact that quantile regression has not been widely used to compute psychometric test norms. At least we do not know of a single test in which this method was applied. Therefore, although quantile regression may certainly be utile for the determination of specific cutoffs or for other particular psychometric purposes, we have nevertheless decided to concentrate in this article on those approaches that are actually in use for the computation of continuous test norms.
The most widely used approach, parametric continuous norming, has so far mainly been applied in intelligence tests such as the Wechsler series and KABC-II [8–14]. To our knowledge, the first test to introduce this kind of continuous norming was the WAIS-R [8]. This intelligence test for adults was launched in the U.S. in 1981. Its norming procedure is based on the assumption that the raw scores are normally distributed at each single age level [15]. Hence, the normative sample of the WAIS-R was split up into different age groups, for which the means and the standard deviations of the raw scores were computed separately. Subsequently, polynomial regression was used to model these two parameters as a function of age. As a result, the estimated mean and standard deviation of the raw score distribution could be determined easily from the regression equations for any specific age level within the normative sample. Finally, norm scores could be calculated for each raw score and age from these two parameters based on the normality assumption. However, violations of this assumption can severely bias norm scores generated with this method. Unfortunately, such violations frequently occur in psychometric tests. This drawback holds particularly true for tests that cover a wide age range, since floor and ceiling effects often occur at the boundaries of such an age range. Furthermore, in this relatively simple type of continuous norming, the means and standard deviations are modeled separately, which can lead to suboptimal data fit at individual age levels.
To address violations of the normality assumption, researchers have suggested to first subject the raw scores to specific transformations aiming to approximate the raw score distribution to a normal distribution. For example, Cole and Green [16,17] used the so-called Box-Cox transformation for this purpose (see Fig 2A, family of functions 2). In addition to parameters for location and dispersion, the Box-Cox transformation has an additional skewness parameter λ, which can also be fitted across age. In further developments of this method [18–21], various families of functions have been used to transform the raw scores in such a way that the probability density of the resulting distribution is known. The functions vary in complexity, but generally possess three or more parameters capturing the location, dispersion, skewness and sometimes also the kurtosis of the raw score distribution. These parameters are used to approximate the probability densities of the raw score distributions at a fixed age. The age progression of the parameters is subsequently modeled with polynomial regression or related mathematical procedures (e.g., splines). In addition, the individual parameters are generally not fitted independently across age. Instead, joint likelihood functions are used, that is, the probability for the whole set of parameter values is maximized simultaneously. In line with the general statistical nomenclature, we summarize this type of norming procedure under the term parametric norming (Fig 2). Note that the specificity of this approach is not necessarily to use a specific number of parameters to model a distribution, but instead to use specific families of functions with characteristic shape (e.g., normal distribution, t distribution, exponential power distribution, beta-binomial distribution, SinH-ArcsinH distribution, and many more). For example, a function with only three parameters might fit a scale better than a function with four parameters when the typical shape of the three-parameter function is better suited for the specific raw score distribution. Therefore, when using parametric norming methods, the main psychometric task is to select the most suitable distribution function for a specific scale.
Parametric continuous norming.
Known parametric functions are used to model the raw score distributions at specific age levels. The function parameters are subsequently modeled as a function of explanatory variables such as age.
Our own approach [3,22,23] is a mixture between parametric and nonparametric methods and can therefore be characterized as semi-parametric. As with parametric norming, we use a type of parametrization to simultaneously fit the entire dataset. However, as with the nonparametric approach, we make no assumptions about the raw score distribution. Instead, we only assume that a raw score is the result of an interaction between the latent ability to be measured and the applied set of test items. Consequently, the dependent variable in our approach is the raw score–not the norm score. The age-specific person location θage (i.e., the level of the latent ability with regard to those persons of the reference population who have the same age) and the age a both serve as independent variables. As an estimator for θage, we use the empirically observed percentiles, which are subjected to normal rank transformation prior to the modeling procedure (= observed location, l). The observed locations thus correspond to conventional norm scores. To fit the model, we apply polynomial regression. However, in contrast to the approaches described above, we do not fit curves, but a two-dimensional surface (age x location) in a three-dimensional space (age x location x raw score, Fig 3). The method can therefore be characterized as a regression-based fit of a hyperplane.
Semi-parametric continuous norming.
Polynomial regression is applied to model a two-dimensional surface (age x location) in a three-dimensional space (age x location x raw score).
To better illustrate the rationale of this method, consider the optimal norming function rexp = f(θage, a). This function determines the expected raw score rexp, a person with location θage and age a is most likely to achieve on a given test scale. The problem with parametric methods is that even with the optimal parameter specification, the used families of functions are not necessarily able to adequately model the shape of this optimal norming function. For example, the normal distribution cannot model functions with skewness or kurtosis. Likewise, functions with a third parameter for skewness cannot account for kurtosis of the optimal norming function. Therefore, scales with large floor or ceiling effects are usually difficult to model with parametric distributions because they additionally include relevant higher-order moments (e.g., hyperskewness). In contrast, polynomial regression at least theoretically provides an error-free solution for any optimal norming function because an arbitrary set of N finite values can always be described mathematically by a polynomial of degree N-1 as a function of another variable (or several other variables). Consequently, for a sample size of N = 1000, the entire range of expected raw scores could be modeled error-free with a polynomial of degree 999 as a function of person location and age. This means that the following equation would have to be resolved:
A concrete example for applying semi-parametric continuous norming in test construction
R packages and in-depth tutorials exist both for the parametric [21,24] and for the semi-parametric approach [22,23]. Furthermore, a graphical user interface for the semi-parametric approach is available online via https://cnorm.shinyapps.io/cNORM/. With this interface, test constructors can model their data and assess whether the approach is adequate for their use case. To help readers, who are interested in applying semi-parametric continuous norming, we want to give a brief overview on the steps. In addition to the following demonstration, we advise readers to consult the online tutorial [22] for additional information and to repeat the procedure with the online user interface.
The procedure consists of the following steps:
Before statistical models are established, it is necessary to collect a sufficiently large normative sample and establish representativeness by stratifying it according to all relevant covariates (e.g., sex, schooling …). The online user interface includes an exemplary dataset on reading comprehension (‘elfe’ [25]) which includes seven age cohorts with the data of 200 children each. To our experience, smaller sample sizes (e.g., 50 cases per cohort, comp. [4,5]) already suffice to model the data, but establishing representativeness becomes increasingly difficult the smaller the dataset.
The next step is to prepare the data (tab “Preparation”) by computing conventional norm scores for the raw score variable, for example by applying a normal rank transformation or determining the percentiles within each age cohort. Afterwards, all powers of the norm score l (l, l2, … lk) and the age variable a (a, a2, … ak) plus the respective interactions (l a, l a2 … lkak) must be computed up to the required degree k, as for example k = 4.
These variables subsequently enter a regression analysis as independent variables with the raw score serving as the dependent variable (tab “Modeling & Validation”). Finally, the significant terms of the polynomial and the respective coefficients are determined to set up the final regression formula [3]. The procedure usually leads to a simple norming models with only three or four significant terms in the regression and a coefficient of determination frequently above .98. It is advisable to keep the number of terms low, even at the expense of R2 in order to avoid overfitting.
Based on the regression function, the percentiles can be plotted (tab “Visualization”) to assess if the model fits the data. It might be necessary to adjust the number of terms in the regression, to rerun the modeling or to conduct a cross validation in order to retrieve optimal results. Finally, the model can be used for compiling norm tables or to directly retrieve norm scores for individual cases or datasets (tab “Prediction”). It is possible to assign norm scores to raw scores or vice versa as a function of age.
Unfortunately, semi-parametric norming–like quantile regression–can lead to intersecting percentile curves, which means that the monotonic relation between norm scores and raw scores at specific age levels is violated. Such inconsistencies most frequently occur when the test scale shows strong floor or ceiling effects (i.e., discriminating between different person locations on the basis of a limited range of raw scores is not possible). Therefore, violations of monotonicity can be used to select optimal models and to determine the valid measuring range [22,23]. In this study, we used them in a very simple way, which is described in the method section.
Verifiability and transparency of norming procedures
As described in the previous section, there are several approaches available to set up continuous norming models. In contrast to other domains of test construction and analysis, quality criteria for evaluating these models are not sufficiently developed though. While statistical indicators for the reliability and validity of a specific test are usually reported in the respective test manuals to prove the test quality, one problem with continuous norming methods is that apart from a few exceptions known to us [26,27], the manuals of psychometric tests rarely provide evidence to prove the goodness of the norming model. Established procedures or specific characteristic values for this purpose are hardly available. Moreover, most test manuals even neglect to sufficiently describe the norming procedure detailed enough to allow for any statistical validation. In case of parametric continuous norming, they usually lack information about the chosen modeling functions. For example, it is not described whether or to which degree these functions fulfill the required distribution assumptions across the whole age range in the specific application. These shortcomings make it difficult for users to assess the limitations of the applied norming procedures and the resulting norm data. In our own efforts to fit psychometric test data on reading comprehension and vocabulary [26,27] with parametric norming methods, we particularly noted systematic deviations between the observed data and the fitted distribution curves at the lower and upper bounds of the raw score distributions and age ranges. The fact that these norming methods lead to biased norm scores especially in the extreme ability ranges, is all the more regrettable as these are the areas of the greatest importance in practical diagnostics [3].
Apart from the question on how to assess and communicate the goodness of fit of statistical norming models, there is also little information about which method provides the best modeling results under specific conditions. For example, the sample size, the distribution of item difficulties, the number of items within a scale and even the type of task or response format (e.g., power vs. speed test) could play a role when it comes to the selection of an optimal method. Since they have hitherto rarely been compared, it is impossible to choose the most suitable method in advance based on existing evidence. Instead, the selection of methods is limited to purely data-driven trial-and-error strategies, which can lead to suboptimal modeling results.
Focus and rationale of research in this simulation study
The purpose of the present simulation study was to make a quantitative comparison of the different continuous norming methods in order to identify specific strengths and weaknesses under various conditions. However, comparing all methods under all possible conditions in one study is not possible. That is why in this article we focused on the two approaches we consider to be the most frequently used at present, namely parametric and semi-parametric continuous norming. In addition, we varied two general conditions that, in our opinion, are probably particularly important with regard to the goodness of fit of the respective methods, namely the sample size and the skewness of the raw score distributions. Variation of the latter was achieved through systematic changes of the average item difficulty.
As described above, the difficulty with parametric methods is to find a function and select a statistical model that fits the raw score distribution with sufficient precision, which is particularly challenging for raw score distributions with pronounced floor or ceiling effects. Therefore, our hypothesis was that the semi-parametric norming should outperform parametric norming in scales that do not provide sufficient items with very high or very low difficulty, that is, in scales that are generally very easy or very difficult for a given age. In addition, we suspected that deviations from an optimal norming model should manifest primarily in extreme ability ranges, because in these ranges the actual raw score distributions generally deviate most from the theoretical distribution assumptions.
A basic assumption of parametric continuous norming is that means, standard deviations, skewness and, where required, kurtosis of the raw score distributions can be estimated with relatively small sample sizes. For example, Zhu and Chen [5] stated that parametric norming with only 50 or 75 subjects per age group generally delivers sufficient goodness of fit. We therefore hypothesized that parametric continuous norming might outperform the semi-parametric approach when using small sample sizes.
Method
Data generation and statistical modeling
In order to assess the goodness of fit of the different continuous norming methods, we first constructed a population model with defined developmental increase of a fictitious ability across age. We subsequently drew random samples of varying size out of this population and simulated a fixed number of item responses for each subject in these samples in accordance with a Rasch model. The average item difficulty of each set of items could be low, medium or high. The item responses were summed to a total test raw score and subjected to the different continuous norming methods. Finally, we evaluated the resulting assignments of raw scores to norm scores by use of a large and completely representative cross-validation sample. The six essential steps of the simulation are depicted in Fig 4. These steps were repeated 3,150 times.
Flow chart of the simulation cycles.
Since we wanted to run the simulation cycles in an automatized way, we had to resort to methods that were both disclosed and available as software implementations, so that we could embed them flexibly in the simulation. We therefore used two open-source R packages in their latest versions: The GAMLSS (= Generalized Additive Models for Location, Scale and Shape) package [24] was applied to do the parametric modeling and the cNORM (= Continuous Norming) package [22,23] was used for the semi-parametric modeling (the packages are described in S1 Appendix; code and raw data is available through S1 Code and S1 Dataset).
The individual steps and features of the simulation are described in more detail below.
Population model
We constructed a developmental model of a fictitious intellectual ability for a population with the following seven age groups: age group 1 [0.5; 1.5[, age group 2 [1.5; 2.5[, age group 3 [2.5; 3.5 [… up to age group 7 [6.5; 7.5[. In addition to age, we assigned two person parameters to each subject. The first parameter, θAge, functioned as a normally distributed and z-standardized person parameter, which represented the fictitious latent ability with respect to all subjects of exactly the same age. The second person parameter θPop, specified the latent ability in relation to the total population, that is, θPop was z-standardized with regard to all seven age groups. θPop was later used to simulate the test results based on the Rasch model (see Table 1 for an overview of statistical abbreviations and symbols). To model the development of the intellectual ability as realistically as possible, we used the normative sample of a real vocabulary test [26] as a blueprint. The following polynomials describe the mean and standard deviation of the unstandardized ability as a function of age:
Mability = 1.5 ∙ Age—0.05 ∙ Age2 + 0.0001 ∙ Age4
SDability = 1 + 0.3 ∙ Age—0.01 ∙ Age2 + 0.00002 ∙ Age4
The z-standardization of this ability across all seven age groups led to the following relation between θPop and θAge:
θPop = (θAge ∙ SDability + Mability—5.097) / 3.128
Statistical abbreviations and symbols used in the simulation.
Fig 5 shows θPop as a function of age. Note that due to the slightly curved increase across age, the latent ability parameter θPop was not normally distributed within the total population but displayed a slight overall positive skew (gm = 0.36).
Age progression of the fictitious ability in the simulated population.
θAge corresponds to the latent ability z-standardized with regard to subjects of exactly the same age and θPop corresponds to the latent ability z-standardized with regard to the total population.
Sampling
We generated normative samples according to the population model described above, that is, each sample contained seven age groups. Each age group had a size of n = 50, 75, 100, 150, 250, 500 or 1,000. We drew two random parameters for each subject in the samples. The first one was age, which was uniformly distributed across the specific age group. The second one was the age-specific latent ability θAge, which was normally distributed with m = 0 and sd = 1. We additionally transformed θAge into θPop as specified by the population model.
Simulation of test scales and test results
We generated three fictitious test scales with 20 test items each, following a Rasch model. We started the construction of these test scales with a scale of medium difficulty. In this scale, the item locations δi matched a perfect normal distribution with a mean value Mδ = 0.0 and standard deviation SDδ = 1.0. As a result, the solution probabilities for the items were equally distributed between 0 and 1, that is, the items were optimally suited for the defined population in the sense that they covered the latent ability very well.
To create two additional scales with stronger floor or ceiling effects, we shifted the average item location to Mδ = -1.0 (easy scale) or Mδ = 1.0 (difficult scale) while keeping a standard deviation of SDδ = 1.0 in each scale.
Because of the curvilinear trajectory of θPop, the skewness of the raw score distributions for the three different test scales varied in the individual age groups, with the medium test scale showing only a weak positive skew on average (gm = 0.14), followed by the easy test scale, which had a moderate negative skew (gm = -0.48). The difficult test scale showed the highest skew (gm = 0.83) of the raw score distributions with a pronounced floor effect at the lowest age group. We therefore assumed that this scale should also entail the strongest differences with regard to the results of the different norming methods.
To simulate the raw score on one of these scales for a subject i, 20 item responses were simulated for this subject according to the Rasch model using the item difficulties of the respective scale. These responses were subsequently summed to a raw score yi of this subject for the respective scale.
Statistical modeling
We subjected each normative sample to parametric and semi-parametric norming methods. The parametric modeling was performed with the lms() function of the GAMLSS package. We specified specific families of distributions with GAMLSS automatically choosing an optimal variant of the respective distribution, such as truncated or stretched. Our focus was originally on the Normal Distribution Family (NO, two parameters) and the Box-Cox Family (BC; including the three-parameter Box-Cox distribution sensu [16], the four-parameter Box-Cox Power Exponential distribution, and a truncated Box-Cox distribution). Since the BC family is not suitable for raw score distributions including zero (as is the case with the simulated data), we additionally used the SinH-ArcsinH distribution (ShASh) as recommended by the authors of the GAMLSS package [21]. Furthermore, to be able to still test the BC family when scores of zero where included in the raw score distributions, we simply added one point to each raw score when using the BC family for the modeling. This procedure is comparable to including a very simple test item in the test scale (i.e., an icebreaker item with a nearly 100% chance of being solved as is used in many psychometric tests). Such an item does not add information about the ability of a person to the test results and should therefore have no major impact on the modeling procedure (apart from the fact that the modeling is also possible with the BC family). This item was deducted when finally assigning raw scores to norm scores in order to be able to compare the assignments across methods.
For the semi-parametric modeling, we used the cNORM package with the default setting of k = 4 as maximum degree of the polynomial, which means that the resulting polynomial could contain up to 24 terms plus the intercept. In order to determine the optimal number of terms in the regression function, we used Ockham's razor, that is, a pragmatic law of parsimony stating that the simplest models should be preferred. Our previous experiments with modeling psychometric data had shown that, as a rule of thumb, usually the first four significant terms in the multiple regression are sufficient to set up a semi-parametric norming model with a coefficient of determination generally above .99. Our very simple selection algorithm was therefore to include four terms in the regression equation by default, and only to search for alternative models in case of violations of monotonicity in the resulting model. (Note that we only took into account violations within the range of the simulated normative data of each simulation cycle.) In case of violations, we started with three terms and consecutively added significant terms until a model without violations of monotonicity was found for the first time. This model was finally selected as the optimum model. If no such model was found, we used the maximum number of terms in the regression equation. In more than 75% of all simulations, this procedure resulted in a polynomial with only three or four terms for the entire norming model. In less than 0.1% of all cycles, the number of terms reached the maximum number of 24.
Cross-validation
The cross-validation sample contained only seven discrete age levels (i.e., 1.0; 2.0; 3.0; 4.0; 5.0; 6.0 and 7.0) with n = 10,000 subjects each, amounting to a total of N = 70,000 subjects. Furthermore, the person locations θAge in this sample matched a perfect normal distribution at each age level, making the sample perfectly representative at these specific levels.
The cross-validation was performed by generating a raw score of the respective test scale for each subject in the cross-validation sample. The generation of test data was performed in exactly the same way as in the normative samples. We subsequently computed conventional norm scores for each of the subjects. To this purpose, we subjected the empirical raw score distribution at each specific age level in the cross-validation sample to a normal rank transformation. Note that we will express these and all other norm scores in the results section in the form of T-scores with MT = 50 and SDT = 10. Given that each age level contained 10,000 subjects and had a perfectly representative distribution of the latent ability, we assumed that the resulting assignment of norm scores to raw scores represented a general upper limit of the norming quality of the respective test scale. We therefore refer to these norm scores as the ideal norm (TIdeal).
Subsequently, we converted the raw scores of each subject in the cross-validation sample into norm scores according to the four continuous norming models (parametric: NO family, BC family, ShASh; semi-parametric: cNORM) established on the basis of the much smaller normative samples. Consequently, five different norm scores were assigned to each subject in the cross-validation sample, namely the four modeled norm scores (TcNORM, TNO, TBC and TShASh) and an ideal norm score (TIdeal), which essentially corresponded to the norm score a person with a specific latent ability and age was statistically expected to achieve. An overview of the statistical abbreviations and symbols is given in Table 1. The norm scores generated with the continuous norming methods were subsequently compared to the ideal norm score with the methods described below.
We performed 150 cycles for each combination of sample size and scale difficulty. This resulted in a total of 7 x 3 x 150 = 3,150 simulation cycles. In some cases, the GAMLSS software failed to return a model for one of the parametric methods. In such cases, we restarted the cycle until a model was returned. cNORM never showed similar problems.
Assessment of model fit
The simulation performed according to the procedure described above has the advantage that both the true age-specific location of each subject (θAge) and the ideal norm score (TIdeal) for this subject are known. Note that θAge and TIdeal do not match perfectly. Instead, TIdeal cannot capture all variance of θAge because of the respective test-scale limitations (i.e., discrete raw scores, limited item numbers, suboptimal item difficulties and the non-linear development of the latent ability).
To compare the model fit of the different methods, we drew on the root mean square error (RMSE), which we determined from the difference between the norm scores predicted on the basis of the normative data (i.e., TcNORM, TNO, TBC or TShASh) and Tideal in the cross-validation samples. Since RMSE is not normally distributed, we decided to count the number of simulation cycles in which each single method showed the lowest total RMSE of all methods. These data were subjected to χ2 tests on equidistribution. The significance level for all tests was set to α = .01 because of the risk of Type I errors with multiple comparisons. To assess the overall dislocation of the modeled norm scores from the norm scores, we additionally computed the Mean Signed Difference (MSD). As the analysis of the MSD was suggested in the review process of the article, we conducted a second simulation to obtain the according values. Therefore, the analysis of MSD and RMSE draws on two different datasets (available as S2 Dataset and S3 Dataset), but with otherwise identical parameters and equivalent results.
We also considered that most psychometricians would not mix both approaches in one norming procedure but would be more likely to choose either parametric or semi-parametric modeling. Furthermore, when using the parametric approach, they would probably compare different families of functions and subsequently choose the one that fits best (e.g., NO, BC or ShASh). To simulate this selection process, we additionally compared each single parametric method to one another and selected in each simulation cycle the one with the lowest RMSE as the best parametric method. Using this procedure it was possible to compare the two different approaches (parametric vs. semi-parametric) in general.
Finally, to be able to also analyze norming errors as a function of the latent ability, we segmented the measurement range (based on TIdeal) between the T-scores 20 and 80 (i.e., norm scores up to +/ - 3 SD) into 12 intervals of five T-scores each and calculated the RMSE separately for these intervals. More extreme norm scores were excluded in this analysis because they usually play no major role in diagnostic decisions.
Results
Fig 6 shows the empirical cumulative distribution functions of the RMSE as a function of scale difficulty (upper panel). In this figure and all following figures, the turquoise line represents the semi-parametric method (cNORM) and the red lines represent the three parametric methods. The figure illustrates that the overall RMSE was below 2 T-score points in almost 98% of all simulation cycles, when cNORM was used to calculate norm scores. In contrast, the cumulative distribution functions of the RMSE for the parametric norming methods showed a cascade-like pattern, indicating that the GAMLSS software generated suboptimal results in a relevant number of simulation cycles. For example, applying the BC family to the easy scale led to more than 50% of simulation cycles with an RMSE above 10 (i.e., higher than 1 SD of the norm score distribution), which is a highly unacceptable value for any diagnostic purpose. Although the software had issued a warning message that the fitting algorithm did not converge in those cases, it had nevertheless returned a statistical model. The MSD (lower panel) illustrates that the parametric approach produced high systematic bias, which strongly depended on scale difficulty. The easy scale, which exhibits a pronounced bottom effect, led to a positive dislocation of the predicted scores in the parametric models and most pronounced in the Box Cox distribution family. The medium scale led to smaller systematic biases mostly in negative direction, with Box Cox being least affected. The difficult scale, which exhibits a ceiling effect, caused a large dislocation in negative direction in all parametric models with a considerable increase with sample size. cNORM in contrast was neither affected by sample size or scale difficulty and showed almost no systematic bias.
RMSE obtained by the different norming methods in the cross-validation sample as a function of scale difficulty (upper panel) and MSD per sample size and difficulty (lower panel).
To give the parametric methods the benefit of doubt and to rule out biases related to missing convergence, we addressed this problem by assuming that an individual norming procedure with GAMLSS–in contrast to the simplified simulation procedure used in this study–would provide ways to avoid such severe mismatches without modifying the norming data (i.e., without eliminating alleged outliers). Therefore, to avoid an unfair bias due to the inclusion of obviously implausible models in the analyses, the descriptive data of RMSE and MSD subsequently reported in Table 2 are based on a cleaned dataset that only includes converged GAMLSS models with an RMSE below 10 (with cNORM, the RMSE was less than 10 in all cases). In this table, the row “Included” reports the percentage of models included in the analysis (i.e., with a total RMSE < 10).
RMSE and MSD as functions of sample size n and scale difficulty in the cleaned dataset.
Across all conditions, GAMLSS produced acceptable models in only 55.6% of all cases. Moreover, the proportion of acceptable models showed a complex pattern of sensitivity to sample size and scale difficulty. Interestingly, the analysis for medium difficulty revealed that the lowest proportion of acceptable models (30.7% across all three parametric methods) was found for a medium sample size of n = 150 per age group. A sample size of n = 100, which is the typical sample size used for continuous norming [8–14], yielded only a slightly higher proportion of acceptable models (35.5% across all three methods). For the scale with high difficulty, the proportion of acceptable models markedly decreased with growing sample size and was generally lower for NO and ShASh (e.g., only 10.7% acceptable models for n = 1,000) compared to BC. For the easy scale, the proportion showed a less uniform and less pronounced dependence on sample size but was generally lower for BC compared to NO and ShASh.
In line with our expectations, the semi-parametric method was by far the most preferable of all four methods when applied to the two suboptimal test scales, with the lowest RMSE in 87.9% of all simulation cycles when applied to the easy test scale, χ2(3) = 2,226.4, p < .001, and the lowest RMSE in 93.7% of all simulation cycles when applied to the difficult test scale, χ2(3) = 2,645.9, p < .001. However, contrary to our expectations, the semi-parametric method also showed the lowest RMSE in 64.0% of all cycles with the medium scale, χ2(3) = 1,057.8, p < .001.
The better performance of cNORM with regard to the suboptimal test scales was evident not only for the total dataset but also for the cleaned dataset (i.e., the data set including only models with RMSE < 10), with the lowest RMSE in 86.3% of all valid simulation cycles (i.e., simulation cycles with at least one parametric model with RMSE < 10) when applied to the easy test scale, χ2(3) = 1,861.1, p < .001, and the lowest RMSE in 88.4% of all valid simulation cycles when applied to the difficult test scale, χ2(3) = 1,217.3, p < .001. Moreover, in the vast majority of conditions, it exhibited the smallest MSD as well, while it has to be noted that in the cleaned data, there were only minor general dislocations in terms of MSD across all conditions and methods. Table 3 shows all pairwise comparisons within the complete (white cells) and the cleaned (grey cells) dataset as a function of scale difficulty.
Pairwise comparisons between the methods in the cross-validation based on lowest RMSE.
It must also be noted, though, that after excluding all models with an RMSE ≥ 10, the general advantage of cNORM regarding the medium test scale vanished and was instead qualified by a threefold interaction between method, scale difficulty, and sample size. This effect is illustrated in Fig 7, which shows the RMSE as a function of approach (semi-parametric vs. best parametric), scale difficulty, and sample size. We included in this figure all simulation cycles returning at least one parametric model with a RMSE < 10. Given that the RMSE is not normally distributed, we chose to depict percentiles of the respective distributions in this figure instead of means and standard deviations. First, as can be seen from all three charts, the RMSE generally decreases with increasing sample size irrespective of the scale difficulty. Against our expectations, this pattern is similar for the semi-parametric and the parametric approach. Second, with regard to the medium test scale, the semi-parametric approach numerically performed best when the sample size was n = 75, 100 and 150 per age group. Yet, the counts yielded only a marginally significant difference for n = 75 (p = .07). Moreover, the parametric approach outperformed the semi-parametric when the sample size was n = 250 or higher (p < .001 for all tests). Note, however, that these sample sizes are only rarely used for continuous norming and that there was a selective dropout of the parametric models with increasing sample size. Third, in line with our hypotheses, the results produced with cNORM showed almost no dependence on scale difficulty, with an average RMSE of 1.1 for all three scale difficulties. In contrast, the results of the parametric approach were affected by scale difficulty, with the best results for the medium test scale (average RMSE = 1.0) and the worst results for the difficult test scale (i.e., the scale with the highest skewness; average RMSE = 1.5).
RMSE as a function of approach (semi-parametric vs. best parametric), sample size n and scale difficulty.
The solid lines represent the 50th percentile, whereas the dashed lines represent the 25th resp. 75th percentile. This analysis includes all simulation cycles with at least one parametric model with an RMSE < 10.
When focusing on the parametric approach only, the modeling results showed a pronounced interaction between the specific method and the scale difficulty (Fig 8). The dependence on scale difficulty was most pronounced for the BC family, which yielded by far the highest norming errors of all parametric methods when applied to the difficult test scale and the lowest when applied to the medium test scale. ShASh and NO also achieved the best results on the medium scale. However, the influence of skewness was much less pronounced for this scale, with ShASh showing the lowest sensitivity to skewness.
RMSE of the three parametric methods as a function of scale difficulty and sample size n.
The figure includes all models with a RMSE < 10.
The relatively low average norming errors reported in the results above do not necessarily implicate superiority of a method across the whole ability range. Fig 9 shows the RMSE of the different methods as a function of scale difficulty and latent ability. The sample size of n = 100, which is typically used for continuous norming, is shown on the left panel. However, we also included a larger sample size of n = 250 (right panel), because BC as well as ShASh on average performed better than cNORM at this sample size and the size is still within the range of real-life application scenarios, whereas the next larger sample size of n = 500 per age group is used very rarely. First, as becomes clear when comparing all six charts depicted in Fig 9, cNORM very reliably delivered a U-shaped distribution of the RMSE as a function of ability independent of sample size and scale difficulty. Moreover, within a critical range of +/ - 2 SDs around the population mean (i.e., T-scores 30–70), the RMSE never exceeded a T-score of 2. In contrast, RMSE showed obvious spikes at some ability levels when parametric methods were used. This pattern was especially true for the easy and the difficult test scale but also for the medium test scale with a sample size of n = 100. Furthermore, the location of the spikes barely depended on the sample size, which means that the deviations from the ideal norm scores are systematic. The analysis of the MSD also confirmed this result. (An analogous figure, depicting MSD as a function of method, scale difficulty, and latent ability, can be found in S1 Fig). The highest spike occurred between T-scores 30 and 35 when the NO family was used and was approximately 5 T-scores high (easy scale). This result was in line with our expectations that skewed distributions cannot be modeled adequately with a normal distribution. Noteworthy, however, was the fact that spikes of considerable size also occurred when using the BC family. For example, when applying BC to the difficult test scale, a spike occurred between T-score 35 and 40. Moreover, the spike clearly increased with sample size and was as high as 4.5 T-scores for n = 250, which strongly suggests that by using parametric methods, the norming error can significantly increase with sample size at individual locations even though it decreases on average across the whole ability range.
RMSE as a function of method, scale difficulty, and latent ability for sample size n = 100 (left panel) and n = 250 (right panel).
Only when BC or ShASh were applied to the medium test scale with a sample size of n = 250 no such spikes were detectable. Yet, neither BC nor ShASh outperformed cNORM at all ability levels, although both methods were slightly superior to cNORM on average. At T = 37.5, for example, cNORM showed the lowest RMSE of all methods. Hence, the overall differences between BC, ShASh and cNORM under this specific condition were so small that they would rarely have a significant impact on real test results, taking into account rounding accuracy.
Discussion
Summary of results
In this simulation study, we compared the reliability of different parametric and semi-parametric continuous norming methods depending on the skewness of the scale and the sample size. To this end, we repeatedly drew random normative samples with varying size and generated test results for these samples based on a Rasch model. We used test scales with three levels of difficulty, namely, a scale with an optimal distribution of item difficulties (medium scale), a scale with a moderate ceiling effect (easy scale), and a scale with a pronounced floor effect (difficult scale). We subsequently generated statistical norming models from the test results according to the different methods and assessed the model fit with a large and completely representative cross-validation sample.
The semi-parametric approach outperformed the parametric one under most conditions. In line with our expectations, semi-parametric norming yielded significantly lower norming error for the suboptimal test scales with floor or ceiling effects. This superiority was independent of the sample size. The largest differences between the semi-parametric and the parametric approach emerged for the test scale with the highest skewness of the raw score distribution (i.e., the difficult test scale). Note that the main problem is not necessarily the skewness of the data but rather the floor effect. However, given that real psychometric test scales usually have a very limited number of items and that the distribution of item difficulties often is far from perfect, floor and ceiling effects are, in our experience, not the exception but rather the rule.
For the test scale with medium difficulty, the overall performance of both approaches was more balanced. At those sample sizes typically used for continuous norming, the semi-parametric method yielded slightly better results than the best fitting parametric method, while for higher sample sizes it was exactly the opposite.
It was also noteworthy that the quality of the three parametric methods depended to different degrees on the scale difficulty. While the norming error only slightly depended on the scale difficulty when using the ShASh function, the BC family yielded the lowest average norming error of all parametric methods when applied to the medium test scale and the highest when applied to the difficult test scale.
The analysis of the norming error as a function of the latent ability yielded even more detailed results. As expected, the norming error reliably showed a U-shaped distribution when using the semi-parametric method, regardless of sample size and scale difficulty. By contrast, applying the parametric methods resulted in considerable deviations from the ideal norm at specific levels of the latent ability, that is, the individual norming error was low at some ability levels but very high at others. Large deviations of the ideal norm occurred not only in the extreme ability ranges, but also in the moderately above - or below-average ranges. In some cases, the height of the observed spikes even increased with growing sample size. Although the magnitude of the effect depended on the skewness of the scale and the specific parametric function, the same pattern was observable for all three parametric families of functions. Specifically, the spikes were unexpectedly high for the BC family when applied to the difficult test scale. In fact, Cole and Green [16] stated in their original article that the BC function is only suitable for moderate skewness. Nevertheless, we had expected at least a slight performance advantage of the BC family over the NO family for the difficult scale, because when the NO family is used, skewness can only be modeled by truncating the distribution, which only allows a very rough adjustment. Moreover, the norming error depicted in Fig 9 was averaged across all age groups, which means that the spikes must have been even higher at specific age groups. Under unfavorable conditions (e. g., specific combinations of age and ability level), parametric norming can therefore yield individual norming errors of more than half a standard deviation, even if the specific method shows low norming error when averaged across all age levels and abilities. Such deviations from the ideal norm score could, of course, lead to serious diagnostic mistakes.
At this point, it is important to raise the question of how a test author or psychometrician would handle marked deviations from the empirical data at specific ability levels or age groups. The first step in addressing deviations is to detect them. An urgent recommendation when applying continuous norming methods is therefore to visualize and inspect the model fit thoroughly over the entire ability and age range. We will revisit this requirement later. The second step is to interpret the deviations as errors of the norming model and not as outliers or random noise of the empirical data. We are concerned that deviations are often misattributed to the data instead of the statistical model, with the latter being the only valid interpretation in our simulation. In line with this apprehension, one of the authors of the GAMLSS software recommends reducing detectable spikes by eliminating supposed outliers [28]. This procedure would not have reduced the norming errors in the present study but instead would have overestimated the model fit. We therefore suggest to apply this strategy cautiously and sparingly.
Our last hypothesis, which predicted that the semi-parametric method would be more sensitive to a change in sample size than the parametric methods, was not supported. Both approaches benefited from an increase in sample size to about the same extent. It has to be noted, though, that a substantial increase in sample size would in most cases only lead to minor improvements in the precision of individual norm scores. Therefore, the results are still in line with the assumption that continuous norming generally can draw on smaller sample sizes compared to traditional norming procedures to achieve comparable results [4,5]. Moreover, as described above, when using parametric methods, convergence problems and even the deviations from the ideal norm at specific ability levels grow with larger samples. This finding might, in our opinion, result from an increase in statistical power. Given that the parametric modeling to some extent forces the raw score distributions into unsuitable shapes, the overall error can only be kept low when high error is tolerated in some locations. This feature of parametric modeling leads to the paradoxical effect that an increase in sample size might as well increase the bias of the modeled norm scores.
Nevertheless, it must also be taken into account that the smaller the sample size, the more difficult it is to establish sufficient representativeness of the normative sample in real life applications. This is especially true if several stratification variables must be taken into account. Based on our own experience, the usual sample size of n = 100 per age group used for continuous norming can often place enormous demands on the balancing of the most important stratification variables (e.g., age, sex, ethnic group, geographic region etc.). Hence, the combination of semi-parametric norming with moderately large representative samples (e.g., n = 100 to 200) seems to be the most solid approach to psychometric test norming in most application cases, while at the same time being sufficiently cost-effective.
Limitations of the study
One problem we had to deal with in this simulation study was the relatively low percentage of valid models returned by the software used for the parametric approach. Only about half of the parametric models showed satisfactory model fit. In the other half, the used algorithms seemingly did not converge and therefore returned models with unacceptable model fit. This problem even occurred for the test scale with optimal item difficulties, for which we had expected the parametric approach to outperform the semi-parametric one. In our study, we could easily handle this problem by running a sufficiently large number of simulation cycles and including only the converging models in the subsequent analysis. In applied settings, however, psychometricians must analyze only one ‒ often imperfect ‒ dataset. The question therefore is how they should address the problem of non-convergence in real-life applications. In many of our simulation cycles, only one of the applied families of functions failed to yield a converging model, whereas the other models converged. Since we chose the best parametric method only from the converging models, we might have selected suboptimal models in some cases, because perhaps a function that failed to produce a converging solution in a specific case could theoretically have been better suited for the data. Most psychometricians would probably choose the appropriate function in a similar way, that is, based on the lowest RMSE between empirical and modeled data, when applying the parametric approach in practice. Theoretically, it may be more advisable to select the function or family of functions on the basis of the specific data properties (e.g., skewness, kurtosis, sample size, floor and ceiling effects and so on) in advance, rather than adopting a trial-and-error strategy. If, however, the pre-selected function does not return a converging model and the psychometrician meets this problem by sorting out supposed outliers from the normative data, this procedure can again lead to suboptimal models. It is therefore difficult to assess the practical impact of this problem.
Another shortcoming was that in the present study we could not evaluate all available parametric functions but had to pre-select three specific families of functions. We focused on these functions, because they are used in real psychometric tests [29] or were recommended by the authors of GAMLSS [20] under specific conditions. We documented strengths and weaknesses of these families of functions depending on the respective properties of the simulated datasets. The GAMLSS package offers numerous additional functions to model raw score distributions, which might fit our simulated datasets even better than the functions we used. To the best of our knowledge, however, no further simulation studies are available to date in which the goodness of fit of these functions has been demonstrated for scales with specific properties. Consequently, a psychometrician applying the parametric approach in practice would again have no choice but to determine the function on the basis of a pure trial-and-error strategy, which we have already rejected as suboptimal.
There are a few other conditions that may possibly affect the goodness of fit of the evaluated methods, we could not systematically vary in this single study. For example, we used a fixed number of items in the test scales. In practice, a higher number of items could reduce the skewness of a scale, but only if the item difficulties were equally distributed across the whole ability range. Reducing the skewness would be especially beneficial for parametric norming with the BC family. As a consequence, differences between semi-parametric and parametric norming could be partly narrowed. However, as already stated above, a perfect equidistribution of item difficulties across the whole ability range is no realistic scenario, because very easy or very difficult items tend to provide unfavorable item parameters and therefore are often eliminated during test construction.
In addition, we based our simulation on a Rasch model, which is only applicable for pure power tests. One task of future simulation studies would therefore be to check the fit of different norming methods for simulated data with more complex measurement models including speed as well as power components.
Another problem of the simulation study was the necessity to rely on default settings of the respective software packages instead of individual adjustments of parameters as would be the case in applied settings. For example, we used a default smoothing algorithm and an automated model selection within each family of functions when applying the GAMLSS package. Manually selecting the respective parameters might have led to better modeling results. On the other hand, the selection strategy used with cNORM was also extremely simple and far from optimum. It is therefore difficult to assess to what extent an individualized adjustment of the modeling parameters would have influenced the results of this study.
A final limitation of this study is that we did not compare continuous norming to conventional norming. A major reason for this shortcoming is that we wanted to evaluate the continuous norming models at discrete age levels and therefore tailored the cross-validation sample accordingly. However, a major source of error in the application of conventional norming is precisely the fact that the norm scores are not provided for any specific age level, but for large age ranges, with some children being relatively far from the average age of the respective age group. We would not have been able to capture this source of error with the specific design of our study, that is, it would have been biased in favor of conventional norming. Based on our previous experience, we can, however, state that continuous norming generally leads to lower bias of the norm scores when a suitable method is selected and carefully implemented [3]. Fig 10 (lower panel) illustrates this assumption by showing the relation between continuous and discrete norming. The data on which this figure is based were obtained from a real vocabulary test [26]. The conventional norms (depicted as dots) show considerable variation between the individual age groups. A heavily jagged age course is discernible particularly in the ability range, which is strongly below average (PR 2.5). It seems very unlikely that such an irregular pattern would actually reflect the true age progression of a latent ability. In contrast, the continuous norming method (depicted as lines) compensates for the large differences between the individual age groups and provides smooth percentiles across the entire ability range.
Percentile curves generated with the cNORM package based on the normative sample of a real vocabulary test.
The curves show which raw score (y-axis) is assigned to a specific ability level (each represented by a percentile curve) at a certain age (x-axis). The upper panel shows a deliberately ill-executed norming procedure (31 terms, k = 5, raw score RMSE = 3.33, norm score SE = 0.88), whereas the lower panel depicts an optimally executed procedure (7 terms, k = 4, raw score RMSE = 3.83, norm score SE = 1.11).
Recommendations for the evaluation and documentation of continuous norming procedures
Although continuous norming methods have been in use for several decades, few peer-reviewed articles have been published on this topic to date. Moreover, to the best of our knowledge, not a single textbook on psychometrics contains any information about these methods. Even more concerning, however, is the fact that the test manuals themselves also rarely provide sufficient information about the continuous norming methods and the goodness of fit of the resulting models. As a first step to address this problem, we complete our article with a few concrete recommendations for quality assessment and documentation of continuous norming procedures.
Quantitative criteria
In our simulation study, we quantified the fit of the different norming methods with RMSE and MSD. The first is commonly used to evaluate the goodness of fit of statistical models, because it captures all kinds of global and local differences between observed and modeled data and can be applied very flexibly. In our specific case, we used the RMSE to compare observed distributions based on simulated data of an ideal sample with modeled distributions based on simulated data of suboptimal samples. Thus it was possible, to analyze the extent to which the quality of the norm scores generally varied depending on the sample size, the skewness of the raw score distributions, the ability level and the norming method. MSD on the other hand was used to assess a general dislocation of the fitted to the observed scores. Other researchers in this field have suggested calculating confidence intervals for norm scores based on repeated sampling [4,30].
In general, we would like to encourage test authors to generally report more descriptive statistics that play or could play a role in the assessment of the norming procedures. For example, we have demonstrated in this study that the skewness of the raw score distribution (resp. the presence of floor or ceiling effects) is an important criterion with regard to the selection of suitable parametric norming functions. Skewness parameters of the raw score distributions could be reported very easily in test manuals.
Qualitative criteria
Another very simple way to document the quality of the norming models in the test manuals is to provide graphical illustrations of the empirical data and the modeled percentile curves across the entire age and ability range. Contrary to quantitative criteria, the model fit can be assessed intuitively and with only minimum prior knowledge with such illustrations. Compare, for example, the upper and the lower panel of Fig 10, which both depict percentiles modeled with cNORM based on the same norming data of a real vocabulary test. The upper panel shows percentiles we deliberately generated in a negligent and therefore suboptimal way. The lowest percentile curve in this panel (PR 2.5) shows a fairly curvy trajectory, which contradicts theoretical assumptions about the monotony of the vocabulary growth during adolescence. The observed development of the raw scores across age was most likely overfitted in this case. In contrast, the lower panel depicts diligent modeling of the same data set (which, by the way, was based on an extremely simple mathematical model). The coefficient of determination R2 is slightly lower than in the upper panel, but the percentiles are smooth and increase monotonously. It can therefore be assumed that a good model fit has been achieved without overfitting the data, which could further be verified by cross validating the model.
Concluding remarks and outlook
In the field of continuous norming, the scientific discourse on the comparison of different norming methods is largely lacking. Only in the last few years, open source software for that purpose is available to test authors and other scientists in the form of R-packages. Although the mathematical methods and functions are fully disclosed in these software packages, the evaluation and application of the specific continuous norming methods and software packages may still be a major challenge for many test authors. We will gladly provide assistance with the application of our own method and software package, and we have also experienced comparable help with the authors of the GAMLSS package, whom we would like to express our thanks to on this occasion. Both packages provide measures to quantitatively and qualitatively assess and document the quality of the produced norm scores and are therefore very useful tools for improving psychometric tests.
The aim of our work is to provide a more precise assessment of human abilities and achievements and thus also to improve decision-making in the field of applied psychometrics. We hope that with this study we have taken another small step towards achieving this goal.
Supporting information
S1 Appendix [docx]
Description of the technical aspects of the packages GAMLSS and cNORM.
S1 Code [r]
R code for conduction the simulation.
S1 Dataset [rda]
Raw data including the validation sample and the item parameters for usage in the simulation.
S2 Dataset [sav]
Results of the simulation study.
S3 Dataset [sav]
Replication of the results with additional information on ().
S1 Fig [tif]
() per ability level in dependence of method, scale difficulty and sample size.
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- "The dead shall be raised": Multidisciplinary analysis of human skeletons reveals complexity in 19th century immigrant socioeconomic history and identity in New Haven, Connecticut
- Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Drink driving engagement in women: An exploration of context, hazardous alcohol use, and behaviour
- The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study
- Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: A systematic review and meta-analysis
- Expression profile of genes encoding allatoregulatory neuropeptides in females of the spider Parasteatoda tepidariorum (Araneae, Theridiidae)
- “My life after stroke through a camera lens”- A photovoice study on participation in Sweden
- Bacterial community composition of biofilms in milking machines of two dairy farms assessed by a combination of culture-dependent and –independent methods
- Health differences between multiple and single job holders in precarious employment in the Netherlands: A cross-sectional study among Dutch workers
- Clinical evaluation and budget impact analysis of cervical cancer screening using cobas 4800 HPV screening technology in the public sector of South Africa
- Rare earth elements in paddy fields from eroded granite hilly land in a southern China watershed
- High-throughput sequencing analysis of microbial community diversity in response to indica and japonica bar-transgenic rice paddy soils
- Physiological and molecular responses to drought stress in teak (Tectona grandis L.f.)
- Long-term performance of an atrial lead capable of accelerometer based detection of cardiac contractility in patients receiving cardiac resynchronisation therapy
- Ectomycorrhizal fungal communities of secondary tropical forests dominated by Tristaniopsis in Bangka Island, Indonesia
- Downregulation of hippocampal NR2A/2B subunits related to cognitive impairment in a pristane-induced lupus BALB/c mice
- Demonstrating specificity of bioactive peptide nucleic acids (PNAs) targeting microRNAs for practical laboratory classes of applied biochemistry and pharmacology
- Xenopus fraseri: Mr. Fraser, where did your frog come from?
- Competing priorities and second chances - A qualitative exploration of prisoners’ journeys through the Hepatitis C continuum of care
- Evaluating coral trophic strategies using fatty acid composition and indices
- Amyloid β oligomers inhibit growth of human cancer cells
- Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis
- Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women
- 'He usually has what we call normal fevers’: Cultural perspectives on healthy child growth in rural Southeastern Tanzania: An ethnographic enquiry
- Anatomical connections underlying personally-familiar face processing
- Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom Thalassiosira pseudonana
- Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts
- Correction: Development of interval-valued fuzzy GRA with SERVPERF based on subjective and objective weights for evaluation of airline service quality: A case study of Korea low-cost carriers
- Anatomical analysis of antebrachial cutaneous nerve distribution pattern and its clinical implications for sensory reconstruction
- Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line
- Topographic correlation and asymmetry analysis of ganglion cell layer thinning and the retinal nerve fiber layer with localized visual field defects
- Structuring a conceptual model for cost-effectiveness analysis of frailty interventions
- Characteristics of sarcopenia after distal gastrectomy in elderly patients
- Action spectrum for photoperiodic control of thyroid-stimulating hormone in Japanese quail (Coturnix japonica)
- The determinants of lung cancer after detecting a solitary pulmonary nodule are different in men and women, for both chest radiograph and CT
- Taste perception and oral microbiota are associated with obesity in children and adolescents
- Target women: Equity in access to mHealth technology in a non-communicable disease care intervention in Kenya
- Correction: Attitudes to and experiences with body weight control and changes in body weight in relation to all-cause mortality in the general population
- Homogenous HIV-1 subtype B from the Brazilian Amazon with infrequent diverse BF1 recombinants, subtypes F1 and C among blood donors
- Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes
- Loss of control as a violation of expectations: Testing the predictions of a common inconsistency compensation approach in an inclusionary cyberball game
- Living on the edge - circadian habitat usage in pre-weaning European hares (Lepus europaeus) in an intensively used agricultural area
- NMDA receptor activation induces long-term potentiation of glycine synapses
- Antibody response in snakes with boid inclusion body disease
- Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates
- Affirmative citation bias in scientific myth debunking: A three-in-one case study
- Streaming chunk incremental learning for class-wise data stream classification with fast learning speed and low structural complexity
- Time trends in healthy lifestyle among adults in Germany: Results from three national health interview and examination surveys between 1990 and 2011
- The impact of door-to-electrocardiogram time on door-to-balloon time after achieving the guideline-recommended target rate
- A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
- Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitro
- CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress
- Multi-method assessment of whale shark (Rhincodon typus) residency, distribution, and dispersal behavior at an aggregation site in the Red Sea
- Duration of symptoms in the quantification of upper limb disability and impairment for individuals with mild degenerative cervical myelopathy (DCM)
- Expression of genes in the skeletal muscle of individuals with cachexia/sarcopenia: A systematic review
- Correction: Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease
- Alcohol, tobacco and cannabis use are associated with job loss at follow-up: Findings from the CONSTANCES cohort
- Estimation of the incidence of animal rabies in Punjab, India
- G-protein-coupled receptor 40 agonist GW9508 potentiates glucose-stimulated insulin secretion through activation of protein kinase Cα and ε in INS-1 cells
- Reasons behind stymied public hospital governance reform in China
- Cognitive and social congruence in peer-assisted learning – A scoping review
- The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU
- Associations between sexual activity and weight status: Findings from the English Longitudinal Study of Ageing
- Knowledge and practices regarding toxoplasmosis in housewives: A cross sectional study in a northern Mexican city
- Citation gaming induced by bibliometric evaluation: A country-level comparative analysis
- Can we predict which species win when new habitat becomes available?
- Wetlands are keystone habitats for jaguars in an intercontinental biodiversity hotspot
- Research applications of primary biodiversity databases in the digital age
- The Edinburgh Postpartum Depression Scale: Stable structure but subscale of limited value to detect anxiety
- EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation
- Post-exercise high-sensitivity troponin T levels in patients with suspected unstable angina
- Unexpected sawtooth artifact in beat-to-beat pulse transit time measured from patient monitor data
- Development of highly sensitive and low-cost DNA agarose gel electrophoresis detection systems, and evaluation of non-mutagenic and loading dye-type DNA-staining reagents
- Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury
- Macrophage phenotype and its relationship with renal function in human diabetic nephropathy
- Phylogeography of the dugong (Dugong dugon) based on historical samples identifies vulnerable Indian Ocean populations
- Vibrational behavior of psyllids (Hemiptera: Psylloidea): Functional morphology and mechanisms
- Evaluation of the effectiveness and equity of the maternity protection reform in Chile from 2000 to 2015
- Baseline human gut microbiota profile in healthy people and standard reporting template
- Are screening methods useful in feature selection? An empirical study
- Free will beliefs are better predicted by dualism than determinism beliefs across different cultures
- How does the content of nutrients in soil affect the health status of trees in city parks?
- Understanding the intricacy of canid social systems: Structure and temporal stability of red fox (Vulpes vulpes) groups
- The anatomy of a crushing bite: The specialised cranial mechanics of a giant extinct kangaroo
- Nurse-led medicines’ monitoring in care homes, implementing the Adverse Drug Reaction (ADRe) Profile improvement initiative for mental health medicines: An observational and interview study
- Projecting burden of hypertension and its management in Turkey, 2015-2030
- Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase
- Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study
- Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort
- Understanding the effect of producers’ attitudes, perceived norms, and perceived behavioral control on intentions to use antimicrobials prudently on New York dairy farms
- Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity
- Theory of mind in remitted bipolar disorder: Interpersonal accuracy in recognition of dynamic nonverbal signals
- Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats
- Ecological conditions experienced by offspring during pregnancy and early post-natal life determine mandible size in roe deer
- Calculation of the contribution rate of China’s hydraulic science and technology based on a feedforward neural network
- ViraMiner: Deep learning on raw DNA sequences for identifying viral genomes in human samples
- The absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice
- Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis
- Moving model analysis on the transient pressure and slipstream caused by a metro train passing through a tunnel
- The importance of assigning responsibility during evaluation in order to increase student satisfaction from physical education classes: A structural equation model
- Lower dormancy with rapid germination is an important strategy for seeds in an arid zone with unpredictable rainfall
- Gene Cascade Finder: A tool for identification of gene cascades and its application in Caenorhabditis elegans
- Proteomics approach to identify serum biomarkers associated with the progression of diabetes in Korean patients with abdominal obesity
- Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity
- Transcriptome analysis of a nematode resistant and susceptible upland cotton line at two critical stages of Meloidogyne incognita infection and development
- Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies
- Distinguishing mild cognitive impairment from healthy aging and Alzheimer’s Disease: The contribution of the INECO Frontal Screening (IFS)
- Novel application of amino-acid buffered solution for neuroprotection against ischemia/reperfusion injury
- Are unpopular children more likely to get sick? Longitudinal links between popularity and infectious diseases in early childhood
- Vegetation communities on commercial developments are heterogenous and determined by development and landscaping decisions, not socioeconomics
- Falls among community-dwelling older adults in Ethiopia; A preliminary cross-sectional study
- Retraction: Social success of perfumes
- The effect of ethyl alcohol on the severity of injuries in fatal pedestrian victims of traffic crashes
- Drought stress has transgenerational effects on soybean seed germination and seedling vigor
- Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI
- Age-related differences of inter-joint coordination in elderly during squat jumping
- Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient
- Diagnostic performance and image quality of iterative model-based reconstruction of coronary CT angiography using 100 kVp for heavily calcified coronary vessels
- CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer
- Getting your game on: Using virtual reality to improve real table tennis skills
- Microbiological contamination of young children’s hands in rural Bangladesh: Associations with child age and observed hand cleanliness as proxy
- Expansion of the agricultural frontier in the largest South American Dry Forest: Identifying priority conservation areas for snakes before everything is lost
- Utility of lung ultrasound in ANCA-associated vasculitis with lung involvement
- Aerial surveys cause large but ephemeral decreases in bear presence at salmon streams in Kodiak, Alaska
- Exposure to particle debris generated from passenger and truck tires induces different genotoxicity and inflammatory responses in the RAW 264.7 cell line
- Influence of the cultivation medium and pH on the pigmentation of Trichophyton rubrum
- Intra-arterial catheter-directed CT angiography for assessment of endovascular aortic aneurysm repair
- Association of antibiotic exposure with the mortality in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy: A hospital-based retrospective cohort study
- The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6A
- Plasma chemistry in nesting leatherback sea turtles (Dermochelys coriacea) from Florida: Understanding the importance of sample hemolysis effects on blood analytes
- Myotendinous asymmetries derived from the prolonged practice of badminton in professional players
- Computational tools to detect signatures of mutational processes in DNA from tumours: A review and empirical comparison of performance
- Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice
- Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it
- Comparative compositional and functional analyses of Bothrops moojeni specimens reveal several individual variations
- Radiation hardness of cadmium telluride solar cells in proton therapy beam mode
- Bourdieu, networks, and movements: Using the concepts of habitus, field and capital to understand a network analysis of gender differences in undergraduate physics
- A 32-channel parallel transmit system add-on for 7T MRI
- Comparison between Aptima Assays (Hologic) and the Allplex STI Essential Assay (Seegene) for the diagnosis of Sexually transmitted infections
- Knowledge gaps of STIs in Africa; Systematic review
- Correction: Bovine herpesvirus 1 can cross the intact zona pellucida of bovine oocytes after artificial infection
- Distribution of corneal spherical aberration in a Tanzanian population
- Correction: Determinants of physical activity: A path model based on an ecological model of active living
- Wild pollinator activity negatively related to honey bee colony densities in urban context
- Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status
- The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century
- Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
- Nitric oxide regulates the expression of heme carrier protein-1 via hypoxia inducible factor-1α stabilization
- Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes
- Construction of pseudomolecule sequences of Brassica rapa ssp. pekinensis inbred line CT001 and analysis of spontaneous mutations derived via sexual propagation
- Effects of flavoring compounds used in electronic cigarette refill liquids on endothelial and vascular function
- Rural pipeline and willingness to work in rural areas: Mixed method study on students in midwifery and obstetric nursing in Mali
- Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy
- Prevalence of anemia in diabetic adult outpatients in Northeast Ethiopia
- Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319
- Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-Uganda
- Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes
- Current and potential contributions of community pharmacy teams to self-harm and suicide prevention: A qualitative interview study
- Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway
- With or without U(K): A pre-Brexit network analysis of the EU ETS
- Graph-theoretical analysis for energy landscape reveals the organization of state transitions in the resting-state human cerebral cortex
- Task-uninformative visual stimuli improve auditory spatial discrimination in humans but not the ideal observer
- Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomes
- gapFinisher: A reliable gap filling pipeline for SSPACE-LongRead scaffolder output
- A plant biostimulant made from the marine brown algae Ascophyllum nodosum and chitosan reduce Fusarium head blight and mycotoxin contamination in wheat
- Monte-Carlo value analysis of High-Throughput Satellites: Value levers, tradeoffs, and implications for operators and investors
- Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm
- Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning
- Neuropathy and neural plasticity in the subcutaneous white adipose depot
- Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells
- The enemy’s gaze: Immersive virtual environments enhance peace promoting attitudes and emotions in violent intergroup conflicts
- Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae
- Koopman Mode Analysis of agent-based models of logistics processes
- Empirical mode decomposition based long short-term memory neural network forecasting model for the short-term metro passenger flow
- Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy
- Multi-agent reinforcement learning with approximate model learning for competitive games
- Identification of olfactory genes and functional analysis of BminCSP and BminOBP21 in Bactrocera minax
- The use of urinary fluoride excretion to facilitate monitoring fluoride intake: A systematic scoping review
- Development of a family caregiver needs-assessment scale for end-of-life care for senility at home (FADE)
- Epidemiology of pneumonia in the pre-pneumococcal conjugate vaccine era in children 2-59 months of age, in Ulaanbaatar, Mongolia, 2015-2016
- H-EM: An algorithm for simultaneous cell diameter and intensity quantification in low-resolution imaging cytometry
- Public expenditure on Non-Communicable Diseases & Injuries in India: A budget-based analysis
- Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
- uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
- Comparative analysis of postural control and vertical jump performance between three different measurement devices
- Hierarchical multi-view aggregation network for sensor-based human activity recognition
- Clavien–Dindo classification for grading complications after total pharyngolaryngectomy and free jejunum transfer
- Significantly different expression levels of microRNAs associated with vascular invasion in hepatocellular carcinoma and their prognostic significance after surgical resection
- Clinical correlates of workplace injury occurrence and recurrence in adults
- Medicine and the media: Medical experts’ problems and solutions while working with journalists
- Phylogenic classification and virulence genes profiles of uropathogenic E. coli and diarrhegenic E. coli strains isolated from community acquired infections
- Genetic relatedness in carbapenem-resistant isolates from clinical specimens in Ghana using ERIC-PCR technique
- Forest resilience under global environmental change: Do we have the information we need? A systematic review
- Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets
- Controls on planktonic foraminifera apparent calcification depths for the northern equatorial Indian Ocean
- Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
- Children with HIV: A scoping review of auditory processing skills
- Correction: Two distinct actin waves correlated with turns-and-runs of crawling microglia
- Expression of Concern: Neurotoxicity Induced by Bupivacaine via T-Type Calcium Channels in SH-SY5Y Cells
- Sex-dependent and -independent transcriptional changes during haploid phase gametogenesis in the sugar kelp Saccharina latissima
- Vehicle modeling for the analysis of the response of detectors based on inductive loops
- New Mycobacteroides abscessus subsp. massiliense strains with recombinant hsp65 gene laterally transferred from Mycobacteroides abscessus subsp. abscessus: Potential for misidentification of M. abscessus strains with the hsp65-based method
- A prognostic Bayesian network that makes personalized predictions of poor prognostic outcome post resection of pancreatic ductal adenocarcinoma
- Impact of care provider network characteristics on patient outcomes: Usage of social network analysis and a multi-scale community detection
- Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics
- Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Upgraded molecular models of the human KCNQ1 potassium channel
- Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
- Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants
- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
- Validity of six consumer-level activity monitors for measuring steps in patients with chronic heart failure
- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
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- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
- Transport oil product consumption and GHG emission reduction potential in China: An electric vehicle-based scenario analysis
- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
- Acidification effects on isolation of extracellular vesicles from bovine milk
- GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
- Mining version history to predict the class instability
- Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
- Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approach
- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study
- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
- Resolving an 87-year-old taxonomical curiosity with the description of Psylla frodobagginsi sp. nov. (Hemiptera: Sternorrhyncha: Psyllidae), a second distinct Psylla species on the New Zealand endemic plant kōwhai
- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
- HIV prevalence and risk behavior among male and female adults screened for enrolment into a vaccine preparedness study in Maputo, Mozambique
- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
- Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats
- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
- Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
- A self-adaptive deep learning method for automated eye laterality detection based on color fundus photography
- The effect of child marriage on the utilization of maternal health care in Nepal: A cross-sectional analysis of Demographic and Health Survey 2016
- Identification of QTLs for powdery mildew (Podosphaera aphanis; syn. Sphaerotheca macularis f. sp. fragariae) susceptibility in cultivated strawberry (Fragaria ×ananassa)
- Chemical volatiles present in cotton gin trash: A by-product of cotton processing
- PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
- Differential metabolomics networks analysis of menopausal status
- Experimental study of the temporal profile of breath alcohol concentration in a Chinese population after a light meal
- Association between regional brain volumes and BMI z-score change over one year in children
- Relationships between Potentially Toxic Elements in intertidal sediments and their bioaccumulation by benthic invertebrates
- Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study
- Hospital burden of pulmonary arterial hypertension in France
- Understanding the variability of Australian fire weather between 1973 and 2017
- Photon-counting cine-cardiac CT in the mouse
- Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.
- Black “Reading the Mind in the Eyes” task: The development of a task assessing mentalizing from black faces
- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae
- Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects
- Validation of the Rainbow Model of Integrated Care Measurement Tools (RMIC-MTs) in renal care for patient and care providers
- Multiple origins and the population genetic structure of Rubus takesimensis (Rosaceae) on Ulleung Island: Implications for the genetic consequences of anagenetic speciation
- Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction—Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial
- A randomized controlled trial examining the efficacy of an internet-based cognitive behavioral therapy program for adolescents with anxiety disorders
- Optimising outputs from a validated online instrument to measure health-related quality of life (HRQL) in dogs
- Young adults’ perceptions of using wearables, social media and other technologies to detect worsening mental health: A qualitative study
- Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research
- Genetic characterization of fall armyworm (Spodoptera frugiperda) in Ecuador and comparisons with regional populations identify likely migratory relationships
- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
- Cardiac resynchronization therapy-heart failure (CRT-HF) clinic: A novel model of care
- Synteny and phylogenetic analysis of paralogous thyrostimulin beta subunits (GpB5) in vertebrates
- Dual-Subpopulation as reciprocal optional external archives for differential evolution
- NGS analysis in Marfan syndrome spectrum: Combination of rare and common genetic variants to improve genotype-phenotype correlation analysis
- Optimization of cataract surgery follow-up: A standard set of questions can predict unexpected management changes at postoperative week one
- Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Clinical evaluation of General Electric new Swiftscan solution in bone scintigraphy on NaI-camera: A head to head comparison with Siemens Symbia
- Pharmacist-led academic detailing improves statin therapy prescribing for Malaysian patients with type 2 diabetes: Quasi-experimental design
- Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
- Clinical outcomes with neoadjuvant versus adjuvant chemotherapy for triple negative breast cancer: A report from the National Cancer Database
- Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function
- Wikipedia network analysis of cancer interactions and world influence
- Using path signatures to predict a diagnosis of Alzheimer’s disease
- Development and verification of prediction models for preventing cardiovascular diseases
- Additive and heterozygous (dis)advantage GWAS models reveal candidate genes involved in the genotypic variation of maize hybrids to Azospirillum brasilense
- Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
- Transience effect in capture-recapture studies: The importance of its biological meaning
- Detailed global modelling of soil organic carbon in cropland, grassland and forest soils
- Oral dosing for antenatal corticosteroids in the Rhesus macaque
- Retraction: Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
- An analysis on HBsAg, Anti-HCV, Anti-HIV½ and VDRL test results in blood donors according to gender, age range and years
- Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study
- Meaningful work and resilience among teachers: The mediating role of work engagement and job crafting
- The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables test
- Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes
- Characterization of sequentially-staged cancer cells using electrorotation
- Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model
- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
- Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study
- Real-time three-dimensional MRI for the assessment of dynamic carpal instability
- Interim report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using “Neo-Islets,” aggregates of adipose stem and pancreatic islet cells (INAD 012-776)
- The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience
- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
- The association between role model presence and self-regulation in early adolescence: A cross-sectional study
- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
- Methamphetamine regulation of activity and topology of ventral midbrain networks
- Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis
- Occult periprosthetic femoral fractures occur frequently during a long, trapezoidal, double-tapered cementless femoral stem fixation in primary THA
- TCF4 induces enzalutamide resistance via neuroendocrine differentiation in prostate cancer
- Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
- Comparing infiltration rates in soils managed with conventional and alternative farming methods: A meta-analysis
- Correction: Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C Virus
- Radiomics features of the primary tumor fail to improve prediction of overall survival in large cohorts of CT- and PET-imaged head and neck cancer patients
- The complete mitochondrial genome of Calyptogena marissinica (Heterodonta: Veneroida: Vesicomyidae): Insight into the deep-sea adaptive evolution of vesicomyids
- Correction: In vitro larval rearing protocol for the stingless bee species Melipona scutellaris for toxicological studies
- Correction: Morphological and molecular identification of the dioecious “African species Volvox rousseletii (Chlorophyceae) in the water column of a Japanese lake based on field-collected and cultured materials
- Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation
- “…or else I close my ears” How women with obesity want to be approached and treated regarding gestational weight management: A qualitative interview study
- Does a spinal implant alter dual energy X-ray absorptiometry body composition measurements?
- Economic and livestock health impacts of birds on dairies: Evidence from a survey of Washington dairy operators
- Repair of subtotal tympanic membrane perforations: A temporal bone study of several tympanoplasty materials
- Shifts in temperature influence how Batrachochytrium dendrobatidis infects amphibian larvae
- Sequential two-step chromatographic purification of infectious poliovirus using ceramic fluoroapatite and ceramic hydroxyapatite columns
- Frequency and distribution of corneal astigmatism and keratometry features in adult life: Methodology and findings of the UK Biobank study
- Differences in the impedance of cochlear implant devices within 24 hours of their implantation
- Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion
- Expression of Concern: miRNA 17 Family Regulates Cisplatin-Resistant and Metastasis by Targeting TGFbetaR2 in NSCLC
- Group leaders establish cooperative norms that persist in subsequent interactions
- Addis Ababa population-based pattern of cancer therapy, Ethiopia
- Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions
- Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development
- DNA barcoding of coastal ray-finned fishes in Vietnam
- Comparison of climbing-specific strength and endurance between lead and boulder climbers
- The performance of different case definitions for severe influenza surveillance among HIV-infected and HIV-uninfected children aged <5 years in South Africa, 2011–2015
- Analgesic drug use in elderly persons: A population-based study in Southern Italy
- RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
- Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity
- Changing educational gradient in long-term care-free life expectancy among German men, 1997-2012
- A non-parametric significance test to compare corpora
- Evaluating the impact of policies recommending PrEP to subpopulations of men and transgender women who have sex with men based on demographic and behavioral risk factors
- Different levels of statistical learning - Hidden potentials of sequence learning tasks
- Dry period heat stress induces microstructural changes in the lactating mammary gland
- Organic resolution function and effects of platinum nanoparticles on bacteria and organic matter
- High levels of fasting glucose and glycosylated hemoglobin values are associated with hyperfiltration in a Spanish prediabetes cohort. The PREDAPS Study
- Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses
- Dynamic up- and down-regulation of the default (DMN) and extrinsic (EMN) mode networks during alternating task-on and task-off periods
- ERK1/ATF-2 signaling axis contributes to interleukin-1β-induced MMP-3 expression in dermal fibroblasts
- Cytokine profiles of umbilical cord blood mononuclear cells upon in vitro stimulation with lipopolysaccharides of different vaginal gram-negative bacteria
- Everolimus in de novo kidney transplant recipients participating in the Eurotransplant senior program: Results of a prospective randomized multicenter study (SENATOR)
- Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2
- Does effectiveness in performance appraisal improve with rater training?
- National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015
- Affective and enjoyment responses to 12 weeks of high intensity interval training and moderate continuous training in adults with Crohn’s disease
- Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up
- Cabbage stem flea beetle’s (Psylliodes chrysocephala L.) susceptibility to pyrethroids and tolerance to thiacloprid in the Czech Republic
- Implicit learning of artificial grammatical structures after inferior frontal cortex lesions
- Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model
- Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia
- Heat stress responses in a large set of winter wheat cultivars (Triticum aestivum L.) depend on the timing and duration of stress
- Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model
- Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
- Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
- Evaluation of suitable reference genes in Brassica juncea and its wild relative Camelina sativa for qRT-PCR analysis under various stress conditions
- Time-related immunomodulation by stressors and corticosterone transdermal application in toads
- Machine learning discovery of longitudinal patterns of depression and suicidal ideation
- Multi-scale patterns of tick occupancy and abundance across an agricultural landscape in southern Africa
- A matter of taste: Spatial and ontogenetic variations on the trophic ecology of the tiger shark at the Galapagos Marine Reserve
- Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radio
- Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity
- Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?
- A large-scale chromosomal inversion is not associated with life history development in rainbow trout from Southeast Alaska
- Deployment, suicide, and overdose among comorbidity phenotypes following mild traumatic brain injury: A retrospective cohort study from the Chronic Effects of Neurotrauma Consortium
- Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data
- Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
- A quantitative approach for the analysis of clinician recognition of acute respiratory distress syndrome using electronic health record data
- Morphological, microbiological and ultrastructural aspects of sepsis by Aeromonas hydrophila in Piaractus mesopotamicus
- Recidivism rates in individuals receiving community sentences: A systematic review
- The association of intensive care with utilization and costs of outpatient healthcare services and quality of life
- How well do cancer survivor self-classifications of anxiety, depression and stress agree with a standardised tool? Results of a cross-sectional study
- Comparative nutritional characteristics of the three major Chinese Dendrobium species with different growth years
- Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
- Geographic differentiation of agritourism activities in Poland vs. cultural and natural attractiveness of destinations at district level
- Social participation reduces isolation among Japanese older people in urban area: A 3-year longitudinal study
- Explaining age-related decline in theory of mind: Evidence for intact competence but compromised executive function
- Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
- Black people are convicted more for being black than for being poor: The role of social norms and cultural prejudice on biased racial judgments
- Bulked segregant analysis RNA-seq (BSR-Seq) validated a stem resistance locus in Aegilops umbellulata, a wild relative of wheat
- Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits
- Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study
- Soil and vegetation conditions changes following the different sand dune restoration measures on the Zoige Plateau
- Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections
- Emission characteristics of diethylhexyl phthalate (DEHP) from building materials determined using a passive flux sampler and micro-chamber
- Multi-focus microscope with HiLo algorithm for fast 3-D fluorescent imaging
- Pontoscolex corethrurus: A homeless invasive tropical earthworm?
- Modeling reciprocal effects in medical research: Critical discussion on the current practices and potential alternative models
- Does palliative chemotherapy really palliate and are we measuring it correctly? A mixed methods longitudinal study of health related quality of life in advanced soft tissue sarcoma
- Developing cookies formulated with goat cream enriched with conjugated linoleic acid
- The effects of combining focus of attention and autonomy support on shot accuracy in the penalty kick
- Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study
- A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis
- Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt’s postnatal diet
- Antitumor activity of a novel dual functional podophyllotoxin derivative involved PI3K/AKT/mTOR pathway
- Genome-wide developed microsatellites reveal a weak population differentiation in the hoverfly Eupeodes corollae (Diptera: Syrphidae) across China
- Prognosis of severe acquired brain injury: Short and long-term outcome determinants and their potential clinical relevance after rehabilitation. A comprehensive approach to analyze cohort studies
- An in silico investigation of menthol metabolism
- Variant analysis pipeline for accurate detection of genomic variants from transcriptome sequencing data
- Identification of candidate flowering and sex genes in white Guinea yam (D. rotundata Poir.) by SuperSAGE transcriptome profiling
- Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation
- The quality of guidelines for diabetic foot ulcers: A critical appraisal using the AGREE II instrument
- Mastitis risk effect on the economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study
- Confounding by indication of the safety of de-escalation in community-acquired pneumonia: A simulation study embedded in a prospective cohort
- Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach
- Drivers of HIV-1 transmission: The Portuguese case
- Integration of a FT expression cassette into CRISPR/Cas9 construct enables fast generation and easy identification of transgene-free mutants in Arabidopsis
- A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Mass evacuation and increases in long-term care benefits: Lessons from the Fukushima nuclear disaster
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- The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus
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- Inhibition of polymerase chain reaction: Pathogen-specific controls are better than human gene amplification
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- Antimicrobial resistance and molecular genotyping of Salmonella enterica serovar Enteritidis clinical isolates from Guizhou province of Southwestern China
- Measuring sexual relationship power equity among young women and young men South Africa: Implications for gender-transformative programming
- Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice – Vie-KinD study
- The genome of Alcaligenes aquatilis strain BU33N: Insights into hydrocarbon degradation capacity
- A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome
- LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancer
- Lung clearance index to detect the efficacy of Aztreonam lysine inhalation in patients with cystic fibrosis and near normal spirometry – A single-centre feasibility study
- Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh
- Effect of PEPFAR funding policy change on HIV service delivery in a large HIV care and treatment network in Nigeria
- Friends, relatives, sanity, and health: The costs of politics
- European public perceptions of homelessness: A knowledge, attitudes and practices survey
- An overview of the quality assurance programme for HIV rapid testing in South Africa: Outcome of a 2-year phased implementation of quality assurance program
- Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients at low and intermediate risk: A risk specific meta-analysis of randomized controlled trials
- Global smoking trends in inflammatory bowel disease: A systematic review of inception cohorts
- Identification of inflammatory markers suitable for non-invasive, repeated measurement studies in biobehavioral research: A feasibility study
- Genomic analyses reveal an absence of contemporary introgressive admixture between fin whales and blue whales, despite known hybrids
- Tipping the balance towards long-term retention in the HIV care cascade: A mixed methods study in southern Mozambique
- Diagnosis and classification of pediatric acute appendicitis by artificial intelligence methods: An investigator-independent approach
- Stylistic variation on the Donald Trump Twitter account: A linguistic analysis of tweets posted between 2009 and 2018
- Kinematic determinants of scoring success in the fencing flick: Logistic and linear multiple regression analysis
- Preferences for formal and traditional sources of childbirth and postnatal care among women in rural Africa: A systematic review
- Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)
- Associations between industry involvement and study characteristics at the time of trial registration in biomedical research
- A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1
- The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis
- Advancing computational biology and bioinformatics research through open innovation competitions
- Dynamic changes in the physicochemical properties of fresh-cut produce wash water as impacted by commodity type and processing conditions
- Mapping online hate: A scientometric analysis on research trends and hotspots in research on online hate
- Orthogonal projection to latent structures and first derivative for manipulation of PLSR and SVR chemometric models' prediction: A case study
- DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs
- Malaria transmission through the mosquito requires the function of the OMD protein
- Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines
- Governing Tripolye: Integrative architecture in Tripolye settlements
- In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis
- Mortality, perception, and scale: Understanding how predation shapes space use in a wild prey population
- DNA analysis of elasmobranch products originating from Bangladesh reveals unregulated elasmobranch fishery and trade on species of global conservation concern
- Genome-wide analysis of methylation in giant pandas with cataract by methylation-dependent restriction-site associated DNA sequencing (MethylRAD)
- A spherical falling film gas-liquid equilibrator for rapid and continuous measurements of CO2 and other trace gases
- The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review
- Gastroenteritis and respiratory infection outbreaks in French nursing homes from 2007 to 2018: Morbidity and all-cause lethality according to the individual characteristics of residents
- A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction
- De novo transcriptome analysis of Viola ×wittrockiana exposed to high temperature stress
- Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates
- HMGB1 mediates the development of tendinopathy due to mechanical overloading
- Effects of the Best Possible Self intervention: A systematic review and meta-analysis
- Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri
- Adjusting cotton planting density under the climatic conditions of Henan Province, China
- Multiple biomarkers of sepsis identified by novel time-lapse proteomics of patient serum
- PTSD in prison settings: A systematic review and meta-analysis of comorbid mental disorders and problematic behaviours
- The female presence in different organisational positions and performance in secondary schools: Does a woman leader function as mediator?
- Beta power encodes contextual estimates of temporal event probability in the human brain
- Molecular characterization of measles virus strains circulating in Cameroon during the 2013-2016 epidemics
- Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain
- Comprehensive analysis of the internal structure and firmness in American cranberry (Vaccinium macrocarpon Ait.) fruit
- Predicting spinal profile using 3D non-contact surface scanning: Changes in surface topography as a predictor of internal spinal alignment
- Assessment modelling approaches for stocks with spawning components, seasonal and spatial dynamics, and limited resources for data collection
- Qualitative analysis of ward staff experiences during research of a novel suicide-prevention psychological therapy for psychiatric inpatients: Understanding the barriers and facilitators
- De-climatizing food security: Lessons from climate change micro-simulations in Peru
- Influence of musculotendon geometry variability in muscle forces and hip bone-on-bone forces during walking
- An international survey of perceptions of the 2014 FIFA World Cup: National levels of corruption as a context for perceptions of institutional corruption
- Dissuasive effect, information provision, and consumer reactions to the term ‘Biotechnology’: The case of reproductive interventions in farmed fish
- "If I have a cancer, it is not my fault I am a refugee”: A qualitative study with expert stakeholders on cancer care management for Syrian refugees in Jordan
- The effect of the use of a decision aid with individual risk estimation on the mode of delivery after a caesarean section: A prospective cohort study
- Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale
- High-throughput RNA-sequencing identifies mesenchymal stem cell-induced immunological signature in a rat model of corneal allograft rejection
- Evaluation of the pain intensity differences among hospitalized cancer patients based on a nursing information system
- Effects of chitin synthesis inhibitor treatment on Lepeophtheirus salmonis (Copepoda, Caligidae) larvae
- Protective mechanism of 1-methylhydantoin against lung injury induced by paraquat poisoning
- Use of high-content analysis and machine learning to characterize complex microbial samples via morphological analysis
- Investigation of a spatial coupling relationship between carbon emission performance and regional urbanization in China
- A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet
- Excellent outcome after desensitization in high immunologic risk kidney transplantation
- Characterization of a new composite membrane for point of need paper-based micro-scale microbial fuel cell analytical devices
- Acute kidney injury during an ultra-distance race
- A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
- The role of C-reactive protein levels on the association of physical activity with lung function in adults
- The CrowdWater game: A playful way to improve the accuracy of crowdsourced water level class data
- Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke
- CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein
- Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model
- Improved ICU mortality prediction based on SOFA scores and gastrointestinal parameters
- Social information use and collective foraging in a pursuit diving seabird
- Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES)
- Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis
- Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpes simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland
- Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada
- Characterization of Monkeypox virus dissemination in the black-tailed prairie dog (Cynomys ludovicianus) through in vivo bioluminescent imaging
- LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells
- How do seabirds modify their search behaviour when encountering fishing boats?
- The diagnostic value of pleural fluid homocysteine in malignant pleural effusion
- Spatio-temporal variations in wheat aphid populations and their natural enemies in four agro-ecological zones of Pakistan
- Factors associated with burnout amongst healthcare workers providing HIV care in Malawi
- A high-density exome capture genotype-by-sequencing panel for forestry breeding in Pinus radiata
- Self-management action and motivation of Pacific adults in New Zealand with end-stage renal disease
- Drought mediated physiological and molecular changes in muskmelon (Cucumis melo L.)
- A prospective randomized trial on abacavir/lamivudine plus darunavir/ritonavir or raltegravir in HIV-positive drug-naïve patients with CD4<200 cells/uL (the PRADAR study)
- Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Multi-dimensional evaluation of response to salt stress in wheat
- Tuberculosis in the wild boar: Frequentist and Bayesian estimations of diagnostic test parameters when Mycobacterium bovis is present in wild boars but at low prevalence
- Enhanced mechanical and thermal properties of electrically conductive TPNR/GNP nanocomposites assisted with ultrasonication
- Geospatial modeling of microcephaly and zika virus spread patterns in Brazil
- Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia
- A ten-year review of ESBL and non-ESBL Escherichia coli bloodstream infections among children at a tertiary referral hospital in South Africa
- Reference values for the cervical spinal canal and the vertebral bodies by MRI in a general population
- Dynamic mechanical characteristics and failure mode of serpentine under a three-dimensional high static load and frequent dynamic disturbance
- Incorporating statistical strategy into image analysis to estimate effects of steam and allyl isocyanate on weed control
- Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20
- The erythrocyte membrane stability is associated with sleep time and social jetlag in shift workers
- New space-time block codes from spectral norm
- Mexican BRCA1 founder mutation: Shortening the gap in genetic assessment for hereditary breast and ovarian cancer patients
- GIVE me your attention: Differentiating goal identification and goal execution components of the anti-saccade effect
- Maternal serum retinol, 25(OH)D and 1,25(OH)2D concentrations during pregnancy and peak bone mass and trabecular bone score in adult offspring at 26-year follow-up
- Self Multi-Head Attention-based Convolutional Neural Networks for fake news detection
- Why are Chinese workers so unhappy? A comparative cross-national analysis of job satisfaction, job expectations, and job attributes
- Fecal indicator bacteria and virus removal in stormwater biofilters: Effects of biochar, media saturation, and field conditioning
- Personalized microstructural evaluation using a Mahalanobis-distance based outlier detection strategy on epilepsy patients’ DTI data – Theory, simulations and example cases
- Radiographic assessment of pectoral flipper bone maturation in bottlenose dolphins (Tursiops truncatus), as a novel technique to accurately estimate chronological age
- Intraoperative measurement of intraventricular pressure in dogs with communicating internal hydrocephalus
- Relative importance of gene effects for nitrogen-use efficiency in popcorn
- Comparative analysis uncovers the limitations of current molecular detection methods for Fusarium oxysporum f. sp. cubense race 4 strains
- The accuracy of the frontal extent in stereoscopic environments: A comparison of direct selection and virtual cursor techniques
- Confronting pastoralists’ knowledge of cattle breeds raised in the extensive production systems of Benin with multivariate analyses of morphological traits
- CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease
- Decontamination of aerosolised bacteria from a pig farm environment using a pH neutral electrochemically activated solution (Ecas4 anolyte)
- Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling
- Simultaneous transcriptome analysis of oil palm clones and Phytophthora palmivora reveals oil palm defense strategies
- Antifungal effects of a 1,3,4-thiadiazole derivative determined by cytochemical and vibrational spectroscopic studies
- Risk factors for unsuccessful tuberculosis treatment outcomes in children
- CRISPR-based tools for targeted transcriptional and epigenetic regulation in plants
- Reliability of high-resolution ultrasound and magnetic resonance arthrography of the shoulder in patients with sports-related shoulder injuries
- Spatial-temporal variation characteristics and evolution of the global industrial robot trade: A complex network analysis
- Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- On the sustainability of a family planning program in Nigeria when funding ends
- The epidemiology of antidepressant use in South Korea: Does short-term antidepressant use affect the relapse and recurrence of depressive episodes?
- Injury severity level and associated factors among road traffic accident victims attending emergency department of Tirunesh Beijing Hospital, Addis Ababa, Ethiopia: A cross sectional hospital-based study
- How chimpanzees (Pan troglodytes) share the spoils with collaborators and bystanders
- Seed treatment using methyl jasmonate induces resistance to rice water weevil but reduces plant growth in rice
- Placebo analgesia induced by verbal suggestion in the context of experimentally induced fear and anxiety
- Reconsidering the associations between self-reported alcohol use disorder and mental health problems in the light of co-occurring addictions in young Swiss men
- Learning to assist smokers through encounters with standardized patients: An innovative training for physicians in an Eastern European country
- Serum E-selectin concentration is associated with risk of metabolic syndrome in females
- Lipid and fatty acid dynamics by maternal Pacific bluefin tuna
- Adherence to evidence-based recommendations for surgical site infection prevention: Results among Italian surgical ward nurses
- Novel synergistic fungicidal mixtures of oxathiapiprolin protect sunflower seeds from downy mildew caused by Plasmopara halstedii
- Adjustment of a numerical model for pore pressure generation during an earthquake
- The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China
- Effects of turning frequency on the nutrients of Camellia oleifera shell co-compost with goat dung and evaluation of co-compost maturity
- Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers
- Distribution of SET/I2PP2A protein in gastrointestinal tissues
- Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs
- Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study
- Anatomy of a demand shock: Quantitative analysis of crowding in hospital emergency departments in Victoria, Australia during the 2009 influenza pandemic
- Oregano essential oil vapour prevents Plasmopara viticola infection in grapevine (Vitis Vinifera) and primes plant immunity mechanisms
- Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism
- Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
- Repetitive finger movement and circle drawing in persons with Parkinson’s disease
- The association between family members’ migration and cognitive function among people left behind in China
- Association between long-term adherence to class-I recommended medications and risk for potentially preventable heart failure hospitalizations among younger adults
- Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals
- Agreement between the spatiotemporal gait parameters from two different wearable devices and high-speed video analysis
- In-hospital cardiopulmonary resuscitation of patients with cirrhosis: A population-based analysis
- Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes
- Someone like me: Size-assortative pairing and mating in an Amazonian fish, sailfin tetra Crenuchus spilurus
- Seasonality of antenatal care attendance, maternal dietary intake, and fetal growth in the VHEMBE birth cohort, South Africa
- Are trials of psychological and psychosocial interventions for schizophrenia and psychosis included in the NICE guidelines pragmatic? A systematic review
- Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
- Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes
- Intensity modulated radiation therapy following lumpectomy in early-stage breast cancer: Patterns of use and cost consequences among Medicare beneficiaries
- The ‘Saw but Forgot’ error: A role for short-term memory failures in understanding junction crashes?
- Multiscale Modelling Tool: Mathematical modelling of collective behaviour without the maths
- A comparison of machine learning algorithms for the surveillance of autism spectrum disorder
- Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
- Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms
- Multidrug-resistant profile and prevalence of extended spectrum β-lactamase and carbapenemase production in fermentative Gram-negative bacilli recovered from patients and specimens referred to National Reference Laboratory, Addis Ababa, Ethiopia
- Primary myelofibrosis marrow-derived CD14+/CD34- monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes
- Intersubject MVPD: Empirical comparison of fMRI denoising methods for connectivity analysis
- Why Cohen’s Kappa should be avoided as performance measure in classification
- A novel strategy for interpreting the T-SPOT.TB test results read by an ELISPOT plate imager
- Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer’s patients
- NPHP proteins are binding partners of nucleoporins at the base of the primary cilium
- Intensive measures of luminescence in GaN/InGaN heterostructures
- The effect of a web-based training for improving primary health care providers’ knowledge about diabetes mellitus management in rural China: A pre-post intervention study
- Isolation, identification and characterization of Streptomyces metabolites as a potential bioherbicide
- Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation
- DNA analysis of Castanea sativa (sweet chestnut) in Britain and Ireland: Elucidating European origins and genepool diversity
- Forecasting the impact of population ageing on tuberculosis incidence
- Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering
- Voxelwise statistical methods to localize practice variation in brain tumor surgery
- Identification and evolutionary characterization of salt-responsive transcription factors in the succulent halophyte Suaeda fruticosa
- Integrating temperature-dependent life table data into Insect Life Cycle Model for predicting the potential distribution of Scapsipedus icipe Hugel & Tanga
- Rollout of ShangRing circumcision with active surveillance for adverse events and monitoring for uptake in Kenya
- Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
- Analyzing a networked social algorithm for collective selection of representative committees
- Gene expression profiling of skeletal myogenesis in human embryonic stem cells reveals a potential cascade of transcription factors regulating stages of myogenesis, including quiescent/activated satellite cell-like gene expression
- Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components
- EFForTS-LGraf: A landscape generator for creating smallholder-driven land-use mosaics
- Impact of the severity of negative energy balance on gene expression in the subcutaneous adipose tissue of periparturient primiparous Holstein dairy cows: Identification of potential novel metabolic signals for the reproductive system
- Precision and consistency of the passive leg raising maneuver for determining fluid responsiveness with bioreactance non-invasive cardiac output monitoring in critically ill patients and healthy volunteers
- Optimizing bacterial DNA extraction in urine
- Adherences to oral nutritional supplementation among hospital outpatients: An online cross-sectional survey in Japan
- Effects of inorganic nitrogen and litters of Masson Pine on soil organic carbon decomposition
- Antioxidant properties of potato tubers (Solanum tuberosum L.) as a consequence of genetic potential and growing conditions
- Transcatheter aortic valve implantation versus conservative management for severe aortic stenosis in real clinical practice
- “I put it in my head that the supplement would help me”: Open-placebo improves exercise performance in female cyclists
- Automated diagnosis of heart valve degradation using novelty detection algorithms and machine learning
- Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort study
- Studying the link between physiological performance of Crotalaria ochroleuca and the distribution of Ca, P, K and S in seeds with X-ray fluorescence
- Characterization of bony changes localized to the cervical articular processes in a mixed population of horses
- Heat shock-induced chaperoning by Hsp70 is enabled in-cell
- Disability and its association with sociodemographic factors among elderly persons residing in an urban resettlement colony, New Delhi, India
- Correlates of prenatal and postnatal mother-to-infant bonding quality: A systematic review
- IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma
- Dietary supplementation with the extract from Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets
- How did that interaction make you feel? The relationship between quality of everyday social experiences and emotion in people with and without schizophrenia
- Effects of Lyse-It on endonuclease fragmentation, function and activity
- Overexpression of rice gene OsATG8b confers tolerance to nitrogen starvation and increases yield and nitrogen use efficiency (NUE) in Arabidopsis
- Gait can reveal sleep quality with machine learning models
- Blast vacuolization in AML patients indicates adverse-risk AML and is associated with impaired survival after intensive induction chemotherapy
- Mitochondrial fragmentation and network architecture in degenerative diseases
- Quadriceps muscle strength is a discriminant predictor of dependence in daily activities in nursing home residents
- Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds
- Skin-associated lactic acid bacteria from North American bullfrogs as potential control agents of Batrachochytrium dendrobatidis
- Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection
- The responses of extracellular enzyme activities and microbial community composition under nitrogen addition in an upland soil
- Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking
- Absolute pitch can be learned by some adults
- Anger while driving in Mexico City
- Glomerular hyperfiltration may be a novel risk factor of restrictive spirometry pattern: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2015
- Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
- Multiple evoked and induced alpha modulations in a visual attention task: Latency, amplitude and topographical profiles
- Heart rate variability reduction is related to a high amount of visceral adiposity in healthy young women
- Serum and urinary metabolomics and outcomes in cirrhosis
- Optimal threshold of adherence to lipid lowering drugs in predicting acute coronary syndrome, stroke, or mortality: A cohort study
- Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis
- How Knowledge Stock Exchanges can increase student success in Massive Open Online Courses
- CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters
- Pattern of health care utilization and traditional and complementary medicine use among Ebola survivors in Sierra Leone
- Respiratory variations in pulse pressure and photoplethysmographic waveform amplitude during positive expiratory pressure and continuous positive airway pressure in a model of progressive hypovolemia
- Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational study
- A usability study to improve a clinical decision support system for the prescription of antibiotic drugs
- Occurrence of and risk factors for extended-spectrum cephalosporin-resistant Enterobacteriaceae determined by sampling of all Norwegian broiler flocks during a six month period
- Healthcare facility-based strategies to improve tuberculosis testing and linkage to care in non-U.S.-born population in the United States: A systematic review
- Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation task
- Correction: Potential user interest in new long-acting contraceptives: Results from a mixed methods study in Burkina Faso and Uganda
- Correction: Recombinant rabbit beta nerve growth factor production and its biological effects on sperm and ovulation in rabbits
- Critically ill patients with community-onset intraabdominal infections: Influence of healthcare exposure on resistance rates and mortality
- Validating a popular outpatient antibiotic database to reliably identify high prescribing physicians for patients 65 years of age and older
- Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equation
- Group conquers efficacy: Preschoolers’ imitation under conflict between minimal group membership and behavior efficacy
- Warmth and competence stereotypes about immigrant groups in Germany
- Social resistance drives persistent transmission of Ebola virus disease in Eastern Democratic Republic of Congo: A mixed-methods study
- ER stress activation in the intestinal mucosa but not in mesenteric adipose tissue is associated with inflammation in Crohn’s disease patients
- Enhancing percutaneous pedicle screw fixation with hydroxyapatite granules: A biomechanical study using an osteoporotic bone model
- Optimum plant density for crowding stress tolerant processing sweet corn
- Sign and goal tracker rats process differently the incentive salience of a conditioned stimulus
- Interocular symmetry, intraobserver repeatability, and interobserver reliability of cone density measurements in the 13-lined ground squirrel
- Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy
- Knowledge, attitudes and practices of livestock and aquaculture producers regarding antimicrobial use and resistance in Vietnam
- Scientific sinkhole: The pernicious price of formatting
- Resource consumption of multi-substance users in the emergency room: A neglected patient group
- Association between distress and knowledge among parents of autistic children
- Surgical approach for complete cochlear coverage in EAS-patients after residual hearing loss
- The impact of a rapid molecular identification test on positive blood cultures from critically ill with bacteremia: A pre-post intervention study
- Shortening duration of ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections: A retrospective study
- Measurement and analysis of partial lightning currents in a head phantom
- Within species expressed genetic variability and gene expression response to different temperatures in the rotifer Brachionus calyciflorus sensu stricto
- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury
- Expression of Concern: Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor
- Correlation of CT texture changes with treatment response during radiation therapy for esophageal cancer: An exploratory study
- Modeling spatial variation in density of golden eagle nest sites in the western United States
- Retraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
- Correction: In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
- Gibberellic acid in Citrus spp. flowering and fruiting: A systematic review
- Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
- A novel therapeutic strategy for esophageal varices using endoscopic treatment combined with splenic artery embolization according to the Child-Pugh classification
- Correction: Development of a high-throughput assay to measure measles neutralizing antibodies
- Correction: Provider preference for payment method under a national health insurance scheme: A survey of health insurance-credentialed health care providers in Ghana
- Correction: Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis
- Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India
- Feed-forward visual processing suffices for coarse localization but fine-grained localization in an attention-demanding context needs feedback processing
- Level Set method-based two-dimensional numerical model for simulation of nonuniform open-channel flow
- Compared to non-drinkers, individuals who drink alcohol have a more favorable multisystem physiologic risk score as measured by allostatic load
- Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus
- Retraction: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
- Sugar transporters in Fabaceae, featuring SUT MST and SWEET families of the model plant Medicago truncatula and the agricultural crop Pisum sativum
- Prediction of lymphovascular space invasion in endometrial cancer using the 55-gene signature selected by DNA microarray analysis
- Research on multi-agent genetic algorithm based on tabu search for the job shop scheduling problem
- Diagnosing the current state of out-of-field teaching in high school science and mathematics
- Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production
- Comorbidity of age-related macular degeneration with Alzheimer’s disease: A histopathologic case-control study
- Acute ex vivo changes in brain white matter diffusion tensor metrics
- Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
- The effect of bacteria on planula-larvae settlement and metamorphosis in the octocoral Rhytisma fulvum fulvum
- Sodium alginate potentiates antioxidant defense and PR proteins against early blight disease caused by Alternaria solani in Solanum lycopersicum Linn.
- Ground reaction forces and muscle activity while walking on sand versus stable ground in individuals with pronated feet compared with healthy controls
- Correction: Roadway traffic crash prediction using a state-space model based support vector regression approach
- MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells
- Genetic analysis and fine mapping of a qualitative trait locus wpb1 for albino panicle branches in rice
- Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis
- Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota
- Factors restraining the population growth of Varroa destructor in Ethiopian honey bees (Apis mellifera simensis)
- Coastal proximity of populations in 22 Pacific Island Countries and Territories
- DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
- Genetic characterization of Angiostrongylus larvae and their intermediate host, Achatina fulica, in Thailand
- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
- Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome
- Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma
- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
- Correction: Identification of miRNAs involved in fruit ripening by deep sequencing of Olea europaea L. transcriptome
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